MotifIRF8.H12CORE.0.P.B
Gene (human)IRF8
(GeneCards)
Gene synonyms (human)ICSBP1
Gene (mouse)Irf8
Gene synonyms (mouse)Icsbp, Icsbp1
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
B
Motif length19
ConsensusdWvdRRAAvWGAAASYvvn
GC content38.84%
Information content (bits; total / per base)15.77 / 0.83
Data sourcesChIP-Seq
Aligned words836

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Mouse 27 (157) 0.912 0.987 0.842 0.973 0.945 0.992 4.867 6.703 359.119 1044.071

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 7 experiments median 0.955 0.943 0.835 0.804 0.723 0.713
best 0.998 0.997 0.992 0.989 0.965 0.958
Methyl HT-SELEX, 2 experiments median 0.89 0.877 0.824 0.819 0.744 0.749
best 0.997 0.996 0.988 0.984 0.905 0.904
Non-Methyl HT-SELEX, 5 experiments median 0.955 0.943 0.835 0.804 0.723 0.713
best 0.998 0.997 0.992 0.989 0.965 0.958

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.864 0.556 0.809 0.519
batch 2 0.757 0.548 0.737 0.525
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classTryptophan cluster factors {3.5} (TFClass)
TF familyIRF {3.5.3} (TFClass)
TF subfamily {3.5.3.0} (TFClass)
TFClass IDTFClass: 3.5.3.0.8
HGNCHGNC:5358
MGIMGI:96395
EntrezGene (human)GeneID:3394
(SSTAR profile)
EntrezGene (mouse)GeneID:15900
(SSTAR profile)
UniProt ID (human)IRF8_HUMAN
UniProt ID (mouse)IRF8_MOUSE
UniProt AC (human)Q02556
(TFClass)
UniProt AC (mouse)P23611
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 27 mouse
HT-SELEX 5
Methyl-HT-SELEX 2
PCM
ACGT
01406.084.0180.0166.0
02554.043.079.0160.0
03217.0134.0417.068.0
04311.097.0222.0206.0
05207.0105.0517.07.0
06364.04.0467.01.0
07742.09.021.064.0
08804.06.03.023.0
09125.0290.0386.035.0
1092.058.022.0664.0
1113.00.0820.03.0
12787.08.037.04.0
13790.04.036.06.0
14827.02.04.03.0
1574.0354.0402.06.0
16120.0204.023.0489.0
17344.0108.0277.0107.0
18345.0117.0266.0108.0
19322.0152.0211.0151.0
PFM
ACGT
010.4860.10.2150.199
020.6630.0510.0940.191
030.260.160.4990.081
040.3720.1160.2660.246
050.2480.1260.6180.008
060.4350.0050.5590.001
070.8880.0110.0250.077
080.9620.0070.0040.028
090.150.3470.4620.042
100.110.0690.0260.794
110.0160.00.9810.004
120.9410.010.0440.005
130.9450.0050.0430.007
140.9890.0020.0050.004
150.0890.4230.4810.007
160.1440.2440.0280.585
170.4110.1290.3310.128
180.4130.140.3180.129
190.3850.1820.2520.181
PWM
ACGT
010.66-0.9-0.148-0.228
020.97-1.551-0.96-0.265
030.037-0.440.687-1.106
040.395-0.7580.06-0.014
05-0.01-0.680.901-3.189
060.551-3.6130.8-4.364
071.261-2.982-2.229-1.166
081.341-3.311-3.807-2.144
09-0.5090.3250.61-1.748
10-0.81-1.261-2.1861.15
11-2.664-4.831.361-3.807
121.32-3.08-1.695-3.613
131.324-3.613-1.721-3.311
141.369-4.047-3.613-3.807
15-1.0240.5240.65-3.311
16-0.549-0.024-2.1440.845
170.495-0.6530.28-0.662
180.498-0.5740.239-0.653
190.429-0.3150.009-0.322
Standard thresholds
P-value Threshold
0.001 2.53811
0.0005 3.77716
0.0001 6.35966