IRF8.H12CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF8.H12CORE.0.P.B
Gene (human)	IRF8 (GeneCards)
Gene synonyms (human)	ICSBP1
Gene (mouse)	Irf8
Gene synonyms (mouse)	Icsbp, Icsbp1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	19
Consensus	dWvdRRAAvWGAAASYvvn
GC content	38.84%
Information content (bits; total / per base)	15.77 / 0.83
Data sources	ChIP-Seq
Aligned words	836

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	27 (157)	0.912	0.987	0.842	0.973	0.945	0.992	4.867	6.703	359.119	1044.071

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.955	0.943	0.835	0.804	0.723	0.713
Overall, 7 experiments	best	0.998	0.997	0.992	0.989	0.965	0.958
Methyl HT-SELEX, 2 experiments	median	0.89	0.877	0.824	0.819	0.744	0.749
Methyl HT-SELEX, 2 experiments	best	0.997	0.996	0.988	0.984	0.905	0.904
Non-Methyl HT-SELEX, 5 experiments	median	0.955	0.943	0.835	0.804	0.723	0.713
Non-Methyl HT-SELEX, 5 experiments	best	0.998	0.997	0.992	0.989	0.965	0.958

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.864	0.556	0.809	0.519
batch 2	0.757	0.548	0.737	0.525

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.8
HGNC	HGNC:5358
MGI	MGI:96395
EntrezGene (human)	GeneID:3394 (SSTAR profile)
EntrezGene (mouse)	GeneID:15900 (SSTAR profile)
UniProt ID (human)	IRF8_HUMAN
UniProt ID (mouse)	IRF8_MOUSE
UniProt AC (human)	Q02556 (TFClass)
UniProt AC (mouse)	P23611 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 27 mouse
HT-SELEX	5
Methyl-HT-SELEX	2

PCM	IRF8.H12CORE.0.P.B.pcm
PWM	IRF8.H12CORE.0.P.B.pwm
PFM	IRF8.H12CORE.0.P.B.pfm
Alignment	IRF8.H12CORE.0.P.B.words.tsv
Threshold to P-value map	IRF8.H12CORE.0.P.B.thr
Motif in other formats
JASPAR format	IRF8.H12CORE.0.P.B_jaspar_format.txt
MEME format	IRF8.H12CORE.0.P.B_meme_format.meme
Transfac format	IRF8.H12CORE.0.P.B_transfac_format.txt
Homer format	IRF8.H12CORE.0.P.B_homer_format_0.001.txt IRF8.H12CORE.0.P.B_homer_format_0.0005.txt IRF8.H12CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	406.0	84.0	180.0	166.0
02	554.0	43.0	79.0	160.0
03	217.0	134.0	417.0	68.0
04	311.0	97.0	222.0	206.0
05	207.0	105.0	517.0	7.0
06	364.0	4.0	467.0	1.0
07	742.0	9.0	21.0	64.0
08	804.0	6.0	3.0	23.0
09	125.0	290.0	386.0	35.0
10	92.0	58.0	22.0	664.0
11	13.0	0.0	820.0	3.0
12	787.0	8.0	37.0	4.0
13	790.0	4.0	36.0	6.0
14	827.0	2.0	4.0	3.0
15	74.0	354.0	402.0	6.0
16	120.0	204.0	23.0	489.0
17	344.0	108.0	277.0	107.0
18	345.0	117.0	266.0	108.0
19	322.0	152.0	211.0	151.0

PFM

	A	C	G	T
01	0.486	0.1	0.215	0.199
02	0.663	0.051	0.094	0.191
03	0.26	0.16	0.499	0.081
04	0.372	0.116	0.266	0.246
05	0.248	0.126	0.618	0.008
06	0.435	0.005	0.559	0.001
07	0.888	0.011	0.025	0.077
08	0.962	0.007	0.004	0.028
09	0.15	0.347	0.462	0.042
10	0.11	0.069	0.026	0.794
11	0.016	0.0	0.981	0.004
12	0.941	0.01	0.044	0.005
13	0.945	0.005	0.043	0.007
14	0.989	0.002	0.005	0.004
15	0.089	0.423	0.481	0.007
16	0.144	0.244	0.028	0.585
17	0.411	0.129	0.331	0.128
18	0.413	0.14	0.318	0.129
19	0.385	0.182	0.252	0.181

PWM

	A	C	G	T
01	0.66	-0.9	-0.148	-0.228
02	0.97	-1.551	-0.96	-0.265
03	0.037	-0.44	0.687	-1.106
04	0.395	-0.758	0.06	-0.014
05	-0.01	-0.68	0.901	-3.189
06	0.551	-3.613	0.8	-4.364
07	1.261	-2.982	-2.229	-1.166
08	1.341	-3.311	-3.807	-2.144
09	-0.509	0.325	0.61	-1.748
10	-0.81	-1.261	-2.186	1.15
11	-2.664	-4.83	1.361	-3.807
12	1.32	-3.08	-1.695	-3.613
13	1.324	-3.613	-1.721	-3.311
14	1.369	-4.047	-3.613	-3.807
15	-1.024	0.524	0.65	-3.311
16	-0.549	-0.024	-2.144	0.845
17	0.495	-0.653	0.28	-0.662
18	0.498	-0.574	0.239	-0.653
19	0.429	-0.315	0.009	-0.322

Standard thresholds

P-value	Threshold
0.001	2.53811
0.0005	3.77716
0.0001	6.35966