IRF7.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF7.H12RSNP.1.SM.B
Gene (human)	IRF7 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Irf7
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	23
Consensus	nnvvRAAnCGAAASCGAAAvYvn
GC content	44.86%
Information content (bits; total / per base)	23.23 / 1.01
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	334

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.724	0.704	0.621	0.62	0.556	0.57
Overall, 4 experiments	best	0.872	0.867	0.703	0.715	0.594	0.624
Methyl HT-SELEX, 1 experiments	median	0.587	0.596	0.527	0.544	0.503	0.521
Methyl HT-SELEX, 1 experiments	best	0.587	0.596	0.527	0.544	0.503	0.521
Non-Methyl HT-SELEX, 3 experiments	median	0.809	0.785	0.674	0.671	0.582	0.6
Non-Methyl HT-SELEX, 3 experiments	best	0.872	0.867	0.703	0.715	0.594	0.624

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.876	0.433	0.835	0.596

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.7
HGNC	HGNC:6122
MGI	MGI:1859212
EntrezGene (human)	GeneID:3665 (SSTAR profile)
EntrezGene (mouse)	GeneID:54123 (SSTAR profile)
UniProt ID (human)	IRF7_HUMAN
UniProt ID (mouse)	IRF7_MOUSE
UniProt AC (human)	Q92985 (TFClass)
UniProt AC (mouse)	P70434 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	IRF7.H12RSNP.1.SM.B.pcm
PWM	IRF7.H12RSNP.1.SM.B.pwm
PFM	IRF7.H12RSNP.1.SM.B.pfm
Alignment	IRF7.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	IRF7.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	IRF7.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	IRF7.H12RSNP.1.SM.B_meme_format.meme
Transfac format	IRF7.H12RSNP.1.SM.B_transfac_format.txt
Homer format	IRF7.H12RSNP.1.SM.B_homer_format_0.001.txt IRF7.H12RSNP.1.SM.B_homer_format_0.0005.txt IRF7.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	108.75	96.75	58.75	69.75
02	97.25	109.25	78.25	49.25
03	58.0	129.0	108.0	39.0
04	55.0	121.0	117.0	41.0
05	180.0	29.0	101.0	24.0
06	288.0	10.0	7.0	29.0
07	285.0	22.0	3.0	24.0
08	113.0	97.0	68.0	56.0
09	0.0	314.0	3.0	17.0
10	0.0	0.0	334.0	0.0
11	334.0	0.0	0.0	0.0
12	334.0	0.0	0.0	0.0
13	333.0	0.0	0.0	1.0
14	37.0	110.0	177.0	10.0
15	0.0	298.0	1.0	35.0
16	2.0	2.0	329.0	1.0
17	327.0	1.0	5.0	1.0
18	334.0	0.0	0.0	0.0
19	332.0	0.0	1.0	1.0
20	78.0	107.0	121.0	28.0
21	23.0	126.0	23.0	162.0
22	112.5	54.5	119.5	47.5
23	99.5	78.5	86.5	69.5

PFM

	A	C	G	T
01	0.326	0.29	0.176	0.209
02	0.291	0.327	0.234	0.147
03	0.174	0.386	0.323	0.117
04	0.165	0.362	0.35	0.123
05	0.539	0.087	0.302	0.072
06	0.862	0.03	0.021	0.087
07	0.853	0.066	0.009	0.072
08	0.338	0.29	0.204	0.168
09	0.0	0.94	0.009	0.051
10	0.0	0.0	1.0	0.0
11	1.0	0.0	0.0	0.0
12	1.0	0.0	0.0	0.0
13	0.997	0.0	0.0	0.003
14	0.111	0.329	0.53	0.03
15	0.0	0.892	0.003	0.105
16	0.006	0.006	0.985	0.003
17	0.979	0.003	0.015	0.003
18	1.0	0.0	0.0	0.0
19	0.994	0.0	0.003	0.003
20	0.234	0.32	0.362	0.084
21	0.069	0.377	0.069	0.485
22	0.337	0.163	0.358	0.142
23	0.298	0.235	0.259	0.208

PWM

	A	C	G	T
01	0.26	0.145	-0.344	-0.177
02	0.15	0.265	-0.064	-0.516
03	-0.357	0.429	0.253	-0.742
04	-0.409	0.366	0.332	-0.694
05	0.759	-1.026	0.187	-1.205
06	1.226	-2.004	-2.308	-1.026
07	1.215	-1.287	-2.949	-1.205
08	0.298	0.147	-0.201	-0.391
09	-4.069	1.312	-2.949	-1.527
10	-4.069	-4.069	1.373	-4.069
11	1.373	-4.069	-4.069	-4.069
12	1.373	-4.069	-4.069	-4.069
13	1.37	-4.069	-4.069	-3.545
14	-0.793	0.272	0.742	-2.004
15	-4.069	1.26	-3.545	-0.846
16	-3.203	-3.203	1.358	-3.545
17	1.352	-3.545	-2.578	-3.545
18	1.373	-4.069	-4.069	-4.069
19	1.367	-4.069	-3.545	-3.545
20	-0.067	0.244	0.366	-1.059
21	-1.245	0.406	-1.245	0.654
22	0.294	-0.418	0.353	-0.551
23	0.173	-0.061	0.035	-0.18

Standard thresholds

P-value	Threshold
0.001	-2.19564
0.0005	-0.54454
0.0001	2.97036