IRF7.H12INVIVO.1.SM.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF7.H12INVIVO.1.SM.D
Gene (human)	IRF7 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Irf7
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	19
Consensus	nvWWnCGAAAvYSRWWnhn
GC content	40.99%
Information content (bits; total / per base)	14.693 / 0.773
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8950

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.804	0.792	0.662	0.67	0.579	0.6
Overall, 4 experiments	best	0.918	0.909	0.736	0.749	0.607	0.643
Methyl HT-SELEX, 1 experiments	median	0.613	0.614	0.543	0.556	0.514	0.529
Methyl HT-SELEX, 1 experiments	best	0.613	0.614	0.543	0.556	0.514	0.529
Non-Methyl HT-SELEX, 3 experiments	median	0.91	0.897	0.725	0.738	0.607	0.639
Non-Methyl HT-SELEX, 3 experiments	best	0.918	0.909	0.736	0.749	0.607	0.643

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.856	0.188	0.828	0.552

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.7
HGNC	HGNC:6122
MGI	MGI:1859212
EntrezGene (human)	GeneID:3665 (SSTAR profile)
EntrezGene (mouse)	GeneID:54123 (SSTAR profile)
UniProt ID (human)	IRF7_HUMAN
UniProt ID (mouse)	IRF7_MOUSE
UniProt AC (human)	Q92985 (TFClass)
UniProt AC (mouse)	P70434 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	IRF7.H12INVIVO.1.SM.D.pcm
PWM	IRF7.H12INVIVO.1.SM.D.pwm
PFM	IRF7.H12INVIVO.1.SM.D.pfm
Alignment	IRF7.H12INVIVO.1.SM.D.words.tsv
Threshold to P-value map	IRF7.H12INVIVO.1.SM.D.thr
Motif in other formats
JASPAR format	IRF7.H12INVIVO.1.SM.D_jaspar_format.txt
MEME format	IRF7.H12INVIVO.1.SM.D_meme_format.meme
Transfac format	IRF7.H12INVIVO.1.SM.D_transfac_format.txt
Homer format	IRF7.H12INVIVO.1.SM.D_homer_format_0.001.txt IRF7.H12INVIVO.1.SM.D_homer_format_0.0005.txt IRF7.H12INVIVO.1.SM.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1530.75	3358.75	2199.75	1860.75
02	4173.5	1424.5	2574.5	777.5
03	6237.0	506.0	735.0	1472.0
04	6351.0	969.0	296.0	1334.0
05	2554.0	2783.0	1446.0	2167.0
06	139.0	8148.0	161.0	502.0
07	26.0	31.0	8849.0	44.0
08	8887.0	52.0	3.0	8.0
09	8910.0	24.0	6.0	10.0
10	8754.0	27.0	0.0	169.0
11	2659.0	2366.0	3238.0	687.0
12	222.0	5187.0	222.0	3319.0
13	598.0	1807.0	5881.0	664.0
14	5809.0	477.0	1966.0	698.0
15	6805.0	643.0	511.0	991.0
16	6411.0	792.0	401.0	1346.0
17	2499.0	2237.0	2325.0	1889.0
18	1279.75	2749.75	1062.75	3857.75
19	2305.0	1914.0	2326.0	2405.0

PFM

	A	C	G	T
01	0.171	0.375	0.246	0.208
02	0.466	0.159	0.288	0.087
03	0.697	0.057	0.082	0.164
04	0.71	0.108	0.033	0.149
05	0.285	0.311	0.162	0.242
06	0.016	0.91	0.018	0.056
07	0.003	0.003	0.989	0.005
08	0.993	0.006	0.0	0.001
09	0.996	0.003	0.001	0.001
10	0.978	0.003	0.0	0.019
11	0.297	0.264	0.362	0.077
12	0.025	0.58	0.025	0.371
13	0.067	0.202	0.657	0.074
14	0.649	0.053	0.22	0.078
15	0.76	0.072	0.057	0.111
16	0.716	0.088	0.045	0.15
17	0.279	0.25	0.26	0.211
18	0.143	0.307	0.119	0.431
19	0.258	0.214	0.26	0.269

PWM

	A	C	G	T
01	-0.379	0.406	-0.017	-0.184
02	0.623	-0.451	0.14	-1.055
03	1.024	-1.483	-1.111	-0.418
04	1.043	-0.836	-2.016	-0.516
05	0.132	0.218	-0.436	-0.032
06	-2.763	1.292	-2.619	-1.491
07	-4.372	-4.209	1.374	-3.88
08	1.378	-3.72	-6.051	-5.384
09	1.381	-4.446	-5.601	-5.207
10	1.363	-4.337	-6.892	-2.571
11	0.172	0.056	0.369	-1.178
12	-2.301	0.84	-2.301	0.394
13	-1.317	-0.213	0.966	-1.212
14	0.953	-1.542	-0.129	-1.163
15	1.112	-1.244	-1.473	-0.813
16	1.052	-1.037	-1.715	-0.508
17	0.11	-0.0	0.038	-0.169
18	-0.558	0.206	-0.743	0.544
19	0.03	-0.156	0.039	0.072

Standard thresholds

P-value	Threshold
0.001	2.78976
0.0005	4.07011
0.0001	6.66021