IRF7.H12CORE.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF7.H12CORE.0.S.B
Gene (human)	IRF7 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Irf7
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	nbRAAnCGAAAdYv
GC content	38.27%
Information content (bits; total / per base)	13.992 / 0.999
Data sources	HT-SELEX
Aligned words	7780

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.827	0.826	0.655	0.687	0.561	0.602
Overall, 4 experiments	best	0.957	0.955	0.76	0.768	0.62	0.656
Methyl HT-SELEX, 1 experiments	median	0.612	0.595	0.55	0.551	0.516	0.527
Methyl HT-SELEX, 1 experiments	best	0.612	0.595	0.55	0.551	0.516	0.527
Non-Methyl HT-SELEX, 3 experiments	median	0.938	0.922	0.729	0.762	0.595	0.646
Non-Methyl HT-SELEX, 3 experiments	best	0.957	0.955	0.76	0.768	0.62	0.656

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.774	0.21	0.779	0.567

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.7
HGNC	HGNC:6122
MGI	MGI:1859212
EntrezGene (human)	GeneID:3665 (SSTAR profile)
EntrezGene (mouse)	GeneID:54123 (SSTAR profile)
UniProt ID (human)	IRF7_HUMAN
UniProt ID (mouse)	IRF7_MOUSE
UniProt AC (human)	Q92985 (TFClass)
UniProt AC (mouse)	P70434 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	IRF7.H12CORE.0.S.B.pcm
PWM	IRF7.H12CORE.0.S.B.pwm
PFM	IRF7.H12CORE.0.S.B.pfm
Alignment	IRF7.H12CORE.0.S.B.words.tsv
Threshold to P-value map	IRF7.H12CORE.0.S.B.thr
Motif in other formats
JASPAR format	IRF7.H12CORE.0.S.B_jaspar_format.txt
MEME format	IRF7.H12CORE.0.S.B_meme_format.meme
Transfac format	IRF7.H12CORE.0.S.B_transfac_format.txt
Homer format	IRF7.H12CORE.0.S.B_homer_format_0.001.txt IRF7.H12CORE.0.S.B_homer_format_0.0005.txt IRF7.H12CORE.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2122.75	2486.75	1865.75	1304.75
02	594.25	4456.25	977.25	1752.25
03	4782.0	658.0	2025.0	315.0
04	7103.0	156.0	148.0	373.0
05	7117.0	300.0	65.0	298.0
06	2592.0	2370.0	1101.0	1717.0
07	62.0	7628.0	54.0	36.0
08	0.0	0.0	7780.0	0.0
09	7773.0	6.0	0.0	1.0
10	7393.0	4.0	42.0	341.0
11	6831.0	39.0	37.0	873.0
12	3347.0	1057.0	1323.0	2053.0
13	288.75	1702.75	328.75	5459.75
14	1739.25	3491.25	1586.25	963.25

PFM

	A	C	G	T
01	0.273	0.32	0.24	0.168
02	0.076	0.573	0.126	0.225
03	0.615	0.085	0.26	0.04
04	0.913	0.02	0.019	0.048
05	0.915	0.039	0.008	0.038
06	0.333	0.305	0.142	0.221
07	0.008	0.98	0.007	0.005
08	0.0	0.0	1.0	0.0
09	0.999	0.001	0.0	0.0
10	0.95	0.001	0.005	0.044
11	0.878	0.005	0.005	0.112
12	0.43	0.136	0.17	0.264
13	0.037	0.219	0.042	0.702
14	0.224	0.449	0.204	0.124

PWM

	A	C	G	T
01	0.087	0.245	-0.042	-0.399
02	-1.183	0.828	-0.687	-0.104
03	0.899	-1.082	0.04	-1.815
04	1.294	-2.51	-2.562	-1.647
05	1.296	-1.863	-3.366	-1.87
06	0.287	0.197	-0.568	-0.125
07	-3.412	1.366	-3.545	-3.93
08	-6.768	-6.768	1.385	-6.768
09	1.385	-5.465	-6.768	-6.399
10	1.334	-5.743	-3.785	-1.736
11	1.255	-3.855	-3.904	-0.8
12	0.542	-0.609	-0.385	0.054
13	-1.901	-0.133	-1.772	1.031
14	-0.112	0.584	-0.204	-0.702

Standard thresholds

P-value	Threshold
0.001	2.85881
0.0005	4.18236
0.0001	6.81641