IRF6.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF6.H12RSNP.0.SM.B
Gene (human)	IRF6 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Irf6
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	nvYCGAAACYn
GC content	49.6%
Information content (bits; total / per base)	12.741 / 1.158
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8044

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.969	0.949	0.919	0.899	0.763	0.772
Overall, 3 experiments	best	0.972	0.958	0.927	0.902	0.784	0.787
Methyl HT-SELEX, 1 experiments	median	0.969	0.949	0.927	0.902	0.784	0.787
Methyl HT-SELEX, 1 experiments	best	0.969	0.949	0.927	0.902	0.784	0.787
Non-Methyl HT-SELEX, 2 experiments	median	0.831	0.815	0.75	0.745	0.653	0.663
Non-Methyl HT-SELEX, 2 experiments	best	0.972	0.958	0.919	0.899	0.763	0.772

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.724	0.249	0.442	0.249

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.6
HGNC	HGNC:6121
MGI	MGI:1859211
EntrezGene (human)	GeneID:3664 (SSTAR profile)
EntrezGene (mouse)	GeneID:54139 (SSTAR profile)
UniProt ID (human)	IRF6_HUMAN
UniProt ID (mouse)	IRF6_MOUSE
UniProt AC (human)	O14896 (TFClass)
UniProt AC (mouse)	P97431 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	IRF6.H12RSNP.0.SM.B.pcm
PWM	IRF6.H12RSNP.0.SM.B.pwm
PFM	IRF6.H12RSNP.0.SM.B.pfm
Alignment	IRF6.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	IRF6.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	IRF6.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	IRF6.H12RSNP.0.SM.B_meme_format.meme
Transfac format	IRF6.H12RSNP.0.SM.B_transfac_format.txt
Homer format	IRF6.H12RSNP.0.SM.B_homer_format_0.001.txt IRF6.H12RSNP.0.SM.B_homer_format_0.0005.txt IRF6.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2674.0	2213.0	1208.0	1949.0
02	4600.75	1487.75	1129.75	825.75
03	738.0	5091.0	875.0	1340.0
04	17.0	7973.0	0.0	54.0
05	0.0	0.0	8044.0	0.0
06	8044.0	0.0	0.0	0.0
07	5572.0	0.0	0.0	2472.0
08	8044.0	0.0	0.0	0.0
09	0.0	8044.0	0.0	0.0
10	146.0	3112.0	197.0	4589.0
11	2234.25	1894.25	2621.25	1294.25

PFM

	A	C	G	T
01	0.332	0.275	0.15	0.242
02	0.572	0.185	0.14	0.103
03	0.092	0.633	0.109	0.167
04	0.002	0.991	0.0	0.007
05	0.0	0.0	1.0	0.0
06	1.0	0.0	0.0	0.0
07	0.693	0.0	0.0	0.307
08	1.0	0.0	0.0	0.0
09	0.0	1.0	0.0	0.0
10	0.018	0.387	0.024	0.57
11	0.278	0.235	0.326	0.161

PWM

	A	C	G	T
01	0.285	0.096	-0.509	-0.031
02	0.827	-0.301	-0.576	-0.888
03	-1.001	0.928	-0.831	-0.405
04	-4.65	1.377	-6.797	-3.578
05	-6.797	-6.797	1.385	-6.797
06	1.385	-6.797	-6.797	-6.797
07	1.018	-6.797	-6.797	0.206
08	1.385	-6.797	-6.797	-6.797
09	-6.797	1.385	-6.797	-6.797
10	-2.609	0.436	-2.313	0.824
11	0.105	-0.06	0.265	-0.44

Standard thresholds

P-value	Threshold
0.001	1.41929
0.0005	3.47814
0.0001	7.73743