IRF6.H12CORE.1.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF6.H12CORE.1.S.C
Gene (human)	IRF6 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Irf6
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	17
Consensus	nvvYSAWACCGAAACYn
GC content	49.6%
Information content (bits; total / per base)	18.773 / 1.104
Data sources	HT-SELEX
Aligned words	1142

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 3 experiments	median	0.955	0.935	0.874	0.857	0.733	0.741
Overall, 3 experiments	best	0.963	0.951	0.889	0.863	0.758	0.755
Methyl HT-SELEX, 1 experiments	median	0.955	0.935	0.889	0.863	0.758	0.755
Methyl HT-SELEX, 1 experiments	best	0.955	0.935	0.889	0.863	0.758	0.755
Non-Methyl HT-SELEX, 2 experiments	median	0.807	0.793	0.725	0.716	0.635	0.642
Non-Methyl HT-SELEX, 2 experiments	best	0.963	0.951	0.874	0.857	0.733	0.741

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.63	0.277	0.455	0.287

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.6
HGNC	HGNC:6121
MGI	MGI:1859211
EntrezGene (human)	GeneID:3664 (SSTAR profile)
EntrezGene (mouse)	GeneID:54139 (SSTAR profile)
UniProt ID (human)	IRF6_HUMAN
UniProt ID (mouse)	IRF6_MOUSE
UniProt AC (human)	O14896 (TFClass)
UniProt AC (mouse)	P97431 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	1

PCM	IRF6.H12CORE.1.S.C.pcm
PWM	IRF6.H12CORE.1.S.C.pwm
PFM	IRF6.H12CORE.1.S.C.pfm
Alignment	IRF6.H12CORE.1.S.C.words.tsv
Threshold to P-value map	IRF6.H12CORE.1.S.C.thr
Motif in other formats
JASPAR format	IRF6.H12CORE.1.S.C_jaspar_format.txt
MEME format	IRF6.H12CORE.1.S.C_meme_format.meme
Transfac format	IRF6.H12CORE.1.S.C_transfac_format.txt
Homer format	IRF6.H12CORE.1.S.C_homer_format_0.001.txt IRF6.H12CORE.1.S.C_homer_format_0.0005.txt IRF6.H12CORE.1.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	299.5	342.5	189.5	310.5
02	492.0	361.0	186.0	103.0
03	202.0	480.0	291.0	169.0
04	80.0	831.0	63.0	168.0
05	99.0	121.0	868.0	54.0
06	928.0	84.0	82.0	48.0
07	656.0	101.0	20.0	365.0
08	1126.0	12.0	3.0	1.0
09	1.0	1090.0	14.0	37.0
10	3.0	1116.0	1.0	22.0
11	1.0	0.0	1141.0	0.0
12	1142.0	0.0	0.0	0.0
13	827.0	0.0	0.0	315.0
14	1142.0	0.0	0.0	0.0
15	0.0	1135.0	7.0	0.0
16	36.0	442.0	41.0	623.0
17	359.25	300.25	306.25	176.25

PFM

	A	C	G	T
01	0.262	0.3	0.166	0.272
02	0.431	0.316	0.163	0.09
03	0.177	0.42	0.255	0.148
04	0.07	0.728	0.055	0.147
05	0.087	0.106	0.76	0.047
06	0.813	0.074	0.072	0.042
07	0.574	0.088	0.018	0.32
08	0.986	0.011	0.003	0.001
09	0.001	0.954	0.012	0.032
10	0.003	0.977	0.001	0.019
11	0.001	0.0	0.999	0.0
12	1.0	0.0	0.0	0.0
13	0.724	0.0	0.0	0.276
14	1.0	0.0	0.0	0.0
15	0.0	0.994	0.006	0.0
16	0.032	0.387	0.036	0.546
17	0.315	0.263	0.268	0.154

PWM

	A	C	G	T
01	0.048	0.181	-0.407	0.083
02	0.542	0.233	-0.425	-1.009
03	-0.343	0.517	0.019	-0.52
04	-1.257	1.064	-1.49	-0.526
05	-1.048	-0.85	1.108	-1.639
06	1.175	-1.209	-1.232	-1.753
07	0.828	-1.028	-2.58	0.244
08	1.368	-3.039	-4.1	-4.645
09	-4.645	1.335	-2.903	-2.003
10	-4.1	1.359	-4.645	-2.492
11	-4.645	-5.095	1.381	-5.095
12	1.382	-5.095	-5.095	-5.095
13	1.06	-5.095	-5.095	0.098
14	1.382	-5.095	-5.095	-5.095
15	-5.095	1.376	-3.49	-5.095
16	-2.029	0.435	-1.905	0.777
17	0.229	0.05	0.07	-0.479

Standard thresholds

P-value	Threshold
0.001	-0.40389
0.0005	1.22561
0.0001	4.64131