IRF4.H12RSNP.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF4.H12RSNP.1.S.B
Gene (human)	IRF4 (GeneCards)
Gene synonyms (human)	MUM1
Gene (mouse)	Irf4
Gene synonyms (mouse)	Spip
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	nvvhWMYGAAAChn
GC content	48.24%
Information content (bits; total / per base)	10.487 / 0.749
Data sources	HT-SELEX
Aligned words	8047

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (53)	0.723	0.896	0.609	0.857	0.711	0.872	2.094	3.651	61.553	236.06
Mouse	14 (85)	0.764	0.835	0.665	0.759	0.743	0.821	2.396	2.985	104.538	407.018

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.93	0.926	0.829	0.836	0.759	0.77
Overall, 4 experiments	best	0.998	0.996	0.995	0.992	0.986	0.98
Methyl HT-SELEX, 1 experiments	median	0.992	0.987	0.98	0.971	0.941	0.927
Methyl HT-SELEX, 1 experiments	best	0.992	0.987	0.98	0.971	0.941	0.927
Non-Methyl HT-SELEX, 3 experiments	median	0.868	0.865	0.678	0.702	0.577	0.613
Non-Methyl HT-SELEX, 3 experiments	best	0.998	0.996	0.995	0.992	0.986	0.98

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.953	0.879	0.843	0.606

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.4
HGNC	HGNC:6119
MGI	MGI:1096873
EntrezGene (human)	GeneID:3662 (SSTAR profile)
EntrezGene (mouse)	GeneID:16364 (SSTAR profile)
UniProt ID (human)	IRF4_HUMAN
UniProt ID (mouse)	IRF4_MOUSE
UniProt AC (human)	Q15306 (TFClass)
UniProt AC (mouse)	Q64287 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 14 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	IRF4.H12RSNP.1.S.B.pcm
PWM	IRF4.H12RSNP.1.S.B.pwm
PFM	IRF4.H12RSNP.1.S.B.pfm
Alignment	IRF4.H12RSNP.1.S.B.words.tsv
Threshold to P-value map	IRF4.H12RSNP.1.S.B.thr
Motif in other formats
JASPAR format	IRF4.H12RSNP.1.S.B_jaspar_format.txt
MEME format	IRF4.H12RSNP.1.S.B_meme_format.meme
Transfac format	IRF4.H12RSNP.1.S.B_transfac_format.txt
Homer format	IRF4.H12RSNP.1.S.B_homer_format_0.001.txt IRF4.H12RSNP.1.S.B_homer_format_0.0005.txt IRF4.H12RSNP.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1535.5	3071.5	1912.5	1527.5
02	1509.5	1797.5	3792.5	947.5
03	3431.0	1712.0	1980.0	924.0
04	4264.0	1362.0	924.0	1497.0
05	5365.0	970.0	532.0	1180.0
06	1109.0	4906.0	988.0	1044.0
07	288.0	6107.0	295.0	1357.0
08	55.0	120.0	7820.0	52.0
09	7824.0	129.0	57.0	37.0
10	7485.0	56.0	108.0	398.0
11	7357.0	335.0	160.0	195.0
12	429.0	6491.0	786.0	341.0
13	912.5	3435.5	587.5	3111.5
14	2634.5	2145.5	1761.5	1505.5

PFM

	A	C	G	T
01	0.191	0.382	0.238	0.19
02	0.188	0.223	0.471	0.118
03	0.426	0.213	0.246	0.115
04	0.53	0.169	0.115	0.186
05	0.667	0.121	0.066	0.147
06	0.138	0.61	0.123	0.13
07	0.036	0.759	0.037	0.169
08	0.007	0.015	0.972	0.006
09	0.972	0.016	0.007	0.005
10	0.93	0.007	0.013	0.049
11	0.914	0.042	0.02	0.024
12	0.053	0.807	0.098	0.042
13	0.113	0.427	0.073	0.387
14	0.327	0.267	0.219	0.187

PWM

	A	C	G	T
01	-0.27	0.423	-0.051	-0.275
02	-0.287	-0.112	0.633	-0.752
03	0.533	-0.161	-0.016	-0.777
04	0.751	-0.39	-0.777	-0.295
05	0.98	-0.728	-1.327	-0.533
06	-0.595	0.891	-0.71	-0.655
07	-1.937	1.11	-1.913	-0.393
08	-3.56	-2.802	1.357	-3.614
09	1.357	-2.731	-3.526	-3.938
10	1.313	-3.543	-2.905	-1.616
11	1.296	-1.787	-2.519	-2.323
12	-1.541	1.171	-0.938	-1.769
13	-0.789	0.535	-1.228	0.436
14	0.269	0.064	-0.133	-0.29

Standard thresholds

P-value	Threshold
0.001	4.58831
0.0005	5.47986
0.0001	7.28921