IRF4.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF4.H12RSNP.0.P.B
Gene (human)	IRF4 (GeneCards)
Gene synonyms (human)	MUM1
Gene (mouse)	Irf4
Gene synonyms (mouse)	Spip
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	17
Consensus	dddndGRAAvWGAAASh
GC content	41.34%
Information content (bits; total / per base)	12.766 / 0.751
Data sources	ChIP-Seq
Aligned words	985

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (53)	0.733	0.877	0.666	0.851	0.81	0.913	3.477	5.166	77.796	286.398
Mouse	14 (85)	0.794	0.934	0.746	0.917	0.861	0.957	4.295	6.23	148.409	663.276

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.857	0.853	0.778	0.78	0.709	0.713
Overall, 4 experiments	best	0.988	0.983	0.965	0.952	0.909	0.891
Methyl HT-SELEX, 1 experiments	median	0.988	0.983	0.956	0.943	0.876	0.861
Methyl HT-SELEX, 1 experiments	best	0.988	0.983	0.956	0.943	0.876	0.861
Non-Methyl HT-SELEX, 3 experiments	median	0.725	0.724	0.6	0.617	0.543	0.565
Non-Methyl HT-SELEX, 3 experiments	best	0.988	0.981	0.965	0.952	0.909	0.891

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.627	0.476	0.737	0.644

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.4
HGNC	HGNC:6119
MGI	MGI:1096873
EntrezGene (human)	GeneID:3662 (SSTAR profile)
EntrezGene (mouse)	GeneID:16364 (SSTAR profile)
UniProt ID (human)	IRF4_HUMAN
UniProt ID (mouse)	IRF4_MOUSE
UniProt AC (human)	Q15306 (TFClass)
UniProt AC (mouse)	Q64287 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 14 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	IRF4.H12RSNP.0.P.B.pcm
PWM	IRF4.H12RSNP.0.P.B.pwm
PFM	IRF4.H12RSNP.0.P.B.pfm
Alignment	IRF4.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	IRF4.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	IRF4.H12RSNP.0.P.B_jaspar_format.txt
MEME format	IRF4.H12RSNP.0.P.B_meme_format.meme
Transfac format	IRF4.H12RSNP.0.P.B_transfac_format.txt
Homer format	IRF4.H12RSNP.0.P.B_homer_format_0.001.txt IRF4.H12RSNP.0.P.B_homer_format_0.0005.txt IRF4.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	439.0	171.0	201.0	174.0
02	505.0	107.0	199.0	174.0
03	490.0	102.0	215.0	178.0
04	257.0	236.0	338.0	154.0
05	420.0	158.0	193.0	214.0
06	196.0	14.0	764.0	11.0
07	375.0	25.0	574.0	11.0
08	889.0	15.0	65.0	16.0
09	866.0	26.0	44.0	49.0
10	137.0	476.0	318.0	54.0
11	130.0	122.0	34.0	699.0
12	33.0	4.0	941.0	7.0
13	855.0	13.0	111.0	6.0
14	794.0	29.0	152.0	10.0
15	910.0	6.0	47.0	22.0
16	141.0	512.0	305.0	27.0
17	154.0	313.0	93.0	425.0

PFM

	A	C	G	T
01	0.446	0.174	0.204	0.177
02	0.513	0.109	0.202	0.177
03	0.497	0.104	0.218	0.181
04	0.261	0.24	0.343	0.156
05	0.426	0.16	0.196	0.217
06	0.199	0.014	0.776	0.011
07	0.381	0.025	0.583	0.011
08	0.903	0.015	0.066	0.016
09	0.879	0.026	0.045	0.05
10	0.139	0.483	0.323	0.055
11	0.132	0.124	0.035	0.71
12	0.034	0.004	0.955	0.007
13	0.868	0.013	0.113	0.006
14	0.806	0.029	0.154	0.01
15	0.924	0.006	0.048	0.022
16	0.143	0.52	0.31	0.027
17	0.156	0.318	0.094	0.431

PWM

	A	C	G	T
01	0.575	-0.362	-0.201	-0.344
02	0.715	-0.825	-0.211	-0.344
03	0.685	-0.872	-0.135	-0.322
04	0.042	-0.042	0.315	-0.465
05	0.531	-0.44	-0.242	-0.139
06	-0.226	-2.758	1.128	-2.97
07	0.418	-2.228	0.842	-2.97
08	1.279	-2.697	-1.313	-2.638
09	1.253	-2.191	-1.691	-1.587
10	-0.581	0.656	0.254	-1.493
11	-0.633	-0.695	-1.938	1.039
12	-1.966	-3.769	1.335	-3.347
13	1.24	-2.824	-0.788	-3.469
14	1.166	-2.088	-0.478	-3.052
15	1.302	-3.469	-1.627	-2.347
16	-0.552	0.728	0.213	-2.156
17	-0.465	0.238	-0.962	0.543

Standard thresholds

P-value	Threshold
0.001	3.96471
0.0005	4.96026
0.0001	7.02996