IRF4.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF4.H12INVIVO.0.P.B
Gene (human)	IRF4 (GeneCards)
Gene synonyms (human)	MUM1
Gene (mouse)	Irf4
Gene synonyms (mouse)	Spip
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	18
Consensus	vdWWRRGGAASTGARAvh
GC content	41.62%
Information content (bits; total / per base)	17.41 / 0.967
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (53)	0.759	0.891	0.71	0.881	0.813	0.919	3.819	5.064	81.553	357.337
Mouse	14 (85)	0.785	0.953	0.757	0.947	0.838	0.968	4.644	7.159	154.174	699.42

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.801	0.772	0.735	0.717	0.671	0.661
Overall, 4 experiments	best	0.943	0.914	0.899	0.859	0.83	0.794
Methyl HT-SELEX, 1 experiments	median	0.943	0.914	0.892	0.856	0.804	0.777
Methyl HT-SELEX, 1 experiments	best	0.943	0.914	0.892	0.856	0.804	0.777
Non-Methyl HT-SELEX, 3 experiments	median	0.663	0.64	0.578	0.578	0.537	0.545
Non-Methyl HT-SELEX, 3 experiments	best	0.939	0.905	0.899	0.859	0.83	0.794

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.476	0.327	0.49	0.375

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.4
HGNC	HGNC:6119
MGI	MGI:1096873
EntrezGene (human)	GeneID:3662 (SSTAR profile)
EntrezGene (mouse)	GeneID:16364 (SSTAR profile)
UniProt ID (human)	IRF4_HUMAN
UniProt ID (mouse)	IRF4_MOUSE
UniProt AC (human)	Q15306 (TFClass)
UniProt AC (mouse)	Q64287 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 14 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	IRF4.H12INVIVO.0.P.B.pcm
PWM	IRF4.H12INVIVO.0.P.B.pwm
PFM	IRF4.H12INVIVO.0.P.B.pfm
Alignment	IRF4.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	IRF4.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	IRF4.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	IRF4.H12INVIVO.0.P.B_meme_format.meme
Transfac format	IRF4.H12INVIVO.0.P.B_transfac_format.txt
Homer format	IRF4.H12INVIVO.0.P.B_homer_format_0.001.txt IRF4.H12INVIVO.0.P.B_homer_format_0.0005.txt IRF4.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	438.0	133.0	298.0	131.0
02	583.0	74.0	165.0	178.0
03	700.0	57.0	90.0	153.0
04	563.0	52.0	116.0	269.0
05	243.0	113.0	578.0	66.0
06	552.0	101.0	324.0	23.0
07	182.0	2.0	809.0	7.0
08	21.0	7.0	969.0	3.0
09	985.0	2.0	10.0	3.0
10	963.0	3.0	3.0	31.0
11	52.0	443.0	481.0	24.0
12	46.0	54.0	4.0	896.0
13	27.0	3.0	964.0	6.0
14	882.0	5.0	104.0	9.0
15	712.0	27.0	234.0	27.0
16	919.0	35.0	20.0	26.0
17	153.0	478.0	336.0	33.0
18	185.0	330.0	67.0	418.0

PFM

	A	C	G	T
01	0.438	0.133	0.298	0.131
02	0.583	0.074	0.165	0.178
03	0.7	0.057	0.09	0.153
04	0.563	0.052	0.116	0.269
05	0.243	0.113	0.578	0.066
06	0.552	0.101	0.324	0.023
07	0.182	0.002	0.809	0.007
08	0.021	0.007	0.969	0.003
09	0.985	0.002	0.01	0.003
10	0.963	0.003	0.003	0.031
11	0.052	0.443	0.481	0.024
12	0.046	0.054	0.004	0.896
13	0.027	0.003	0.964	0.006
14	0.882	0.005	0.104	0.009
15	0.712	0.027	0.234	0.027
16	0.919	0.035	0.02	0.026
17	0.153	0.478	0.336	0.033
18	0.185	0.33	0.067	0.418

PWM

	A	C	G	T
01	0.558	-0.625	0.175	-0.64
02	0.843	-1.201	-0.412	-0.337
03	1.025	-1.455	-1.01	-0.487
04	0.808	-1.544	-0.76	0.073
05	-0.028	-0.786	0.834	-1.313
06	0.788	-0.896	0.258	-2.32
07	-0.315	-4.213	1.17	-3.362
08	-2.405	-3.362	1.35	-3.975
09	1.366	-4.213	-3.066	-3.975
10	1.344	-3.975	-3.975	-2.04
11	-1.544	0.569	0.651	-2.281
12	-1.663	-1.508	-3.783	1.272
13	-2.171	-3.975	1.345	-3.484
14	1.256	-3.622	-0.867	-3.156
15	1.042	-2.171	-0.066	-2.171
16	1.297	-1.925	-2.45	-2.206
17	-0.487	0.645	0.294	-1.981
18	-0.299	0.276	-1.298	0.511

Standard thresholds

P-value	Threshold
0.001	1.81681
0.0005	3.10926
0.0001	5.82696