IRF4.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	IRF4.H12INVITRO.0.P.B
Gene (human)	IRF4 (GeneCards)
Gene synonyms (human)	MUM1
Gene (mouse)	Irf4
Gene synonyms (mouse)	Spip
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	17
Consensus	vdRRAASWGARAShnnn
GC content	45.98%
Information content (bits; total / per base)	11.407 / 0.671
Data sources	ChIP-Seq
Aligned words	1016

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (53)	0.768	0.877	0.702	0.852	0.802	0.897	3.339	4.694	89.62	297.328
Mouse	14 (85)	0.802	0.936	0.742	0.909	0.845	0.949	3.885	5.498	152.131	675.886

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.85	0.841	0.784	0.782	0.723	0.723
Overall, 4 experiments	best	0.99	0.985	0.97	0.956	0.927	0.908
Methyl HT-SELEX, 1 experiments	median	0.99	0.985	0.965	0.953	0.899	0.884
Methyl HT-SELEX, 1 experiments	best	0.99	0.985	0.965	0.953	0.899	0.884
Non-Methyl HT-SELEX, 3 experiments	median	0.713	0.702	0.603	0.61	0.546	0.563
Non-Methyl HT-SELEX, 3 experiments	best	0.987	0.98	0.97	0.956	0.927	0.908

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.633	0.457	0.664	0.529

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	IRF {3.5.3} (TFClass)
TF subfamily	{3.5.3.0} (TFClass)
TFClass ID	TFClass: 3.5.3.0.4
HGNC	HGNC:6119
MGI	MGI:1096873
EntrezGene (human)	GeneID:3662 (SSTAR profile)
EntrezGene (mouse)	GeneID:16364 (SSTAR profile)
UniProt ID (human)	IRF4_HUMAN
UniProt ID (mouse)	IRF4_MOUSE
UniProt AC (human)	Q15306 (TFClass)
UniProt AC (mouse)	Q64287 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 14 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	IRF4.H12INVITRO.0.P.B.pcm
PWM	IRF4.H12INVITRO.0.P.B.pwm
PFM	IRF4.H12INVITRO.0.P.B.pfm
Alignment	IRF4.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	IRF4.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	IRF4.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	IRF4.H12INVITRO.0.P.B_meme_format.meme
Transfac format	IRF4.H12INVITRO.0.P.B_transfac_format.txt
Homer format	IRF4.H12INVITRO.0.P.B_homer_format_0.001.txt IRF4.H12INVITRO.0.P.B_homer_format_0.0005.txt IRF4.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	238.0	197.0	430.0	151.0
02	391.0	147.0	228.0	250.0
03	149.0	71.0	747.0	49.0
04	409.0	57.0	522.0	28.0
05	835.0	51.0	89.0	41.0
06	864.0	25.0	83.0	44.0
07	82.0	496.0	398.0	40.0
08	100.0	77.0	38.0	801.0
09	21.0	8.0	980.0	7.0
10	911.0	21.0	66.0	18.0
11	712.0	48.0	237.0	19.0
12	932.0	12.0	25.0	47.0
13	120.0	446.0	421.0	29.0
14	159.0	277.0	136.0	444.0
15	303.0	195.0	317.0	201.0
16	263.0	195.0	379.0	179.0
17	307.0	235.0	288.0	186.0

PFM

	A	C	G	T
01	0.234	0.194	0.423	0.149
02	0.385	0.145	0.224	0.246
03	0.147	0.07	0.735	0.048
04	0.403	0.056	0.514	0.028
05	0.822	0.05	0.088	0.04
06	0.85	0.025	0.082	0.043
07	0.081	0.488	0.392	0.039
08	0.098	0.076	0.037	0.788
09	0.021	0.008	0.965	0.007
10	0.897	0.021	0.065	0.018
11	0.701	0.047	0.233	0.019
12	0.917	0.012	0.025	0.046
13	0.118	0.439	0.414	0.029
14	0.156	0.273	0.134	0.437
15	0.298	0.192	0.312	0.198
16	0.259	0.192	0.373	0.176
17	0.302	0.231	0.283	0.183

PWM

	A	C	G	T
01	-0.065	-0.252	0.524	-0.515
02	0.429	-0.542	-0.107	-0.016
03	-0.529	-1.257	1.074	-1.618
04	0.474	-1.471	0.717	-2.152
05	1.185	-1.579	-1.036	-1.789
06	1.219	-2.258	-1.105	-1.721
07	-1.117	0.666	0.447	-1.813
08	-0.922	-1.178	-1.862	1.144
09	-2.42	-3.269	1.345	-3.377
10	1.272	-2.42	-1.329	-2.562
11	1.026	-1.637	-0.069	-2.513
12	1.295	-2.924	-2.258	-1.658
13	-0.742	0.56	0.503	-2.119
14	-0.464	0.086	-0.619	0.556
15	0.175	-0.262	0.22	-0.232
16	0.035	-0.262	0.398	-0.347
17	0.188	-0.077	0.125	-0.309

Standard thresholds

P-value	Threshold
0.001	4.37576
0.0005	5.27741
0.0001	7.13956