MotifIRF4.H12CORE.2.SM.B
Gene (human)IRF4
(GeneCards)
Gene synonyms (human)MUM1
Gene (mouse)Irf4
Gene synonyms (mouse)Spip
LOGO
LOGO (reverse complement)
Motif subtype2
Quality
B
Motif length17
ConsensusnhWhCGAAACYRvhMhh
GC content45.89%
Information content (bits; total / per base)15.717 / 0.925
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words6345

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 8 (53) 0.69 0.88 0.554 0.825 0.687 0.865 1.876 3.449 41.854 216.678
Mouse 14 (85) 0.752 0.799 0.624 0.704 0.716 0.771 2.105 2.57 85.42 253.119

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.909 0.907 0.819 0.827 0.762 0.772
best 0.998 0.997 0.995 0.993 0.988 0.984
Methyl HT-SELEX, 1 experiments median 0.994 0.99 0.986 0.979 0.958 0.946
best 0.994 0.99 0.986 0.979 0.958 0.946
Non-Methyl HT-SELEX, 3 experiments median 0.825 0.825 0.652 0.675 0.567 0.599
best 0.998 0.997 0.995 0.993 0.988 0.984

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.956 0.894 0.891 0.587
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classTryptophan cluster factors {3.5} (TFClass)
TF familyIRF {3.5.3} (TFClass)
TF subfamily {3.5.3.0} (TFClass)
TFClass IDTFClass: 3.5.3.0.4
HGNCHGNC:6119
MGIMGI:1096873
EntrezGene (human)GeneID:3662
(SSTAR profile)
EntrezGene (mouse)GeneID:16364
(SSTAR profile)
UniProt ID (human)IRF4_HUMAN
UniProt ID (mouse)IRF4_MOUSE
UniProt AC (human)Q15306
(TFClass)
UniProt AC (mouse)Q64287
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 8 human, 14 mouse
HT-SELEX 3
Methyl-HT-SELEX 1
PCM
ACGT
012185.751611.751638.75908.75
022689.51125.5646.51883.5
034562.0654.0246.0883.0
04796.03700.0749.01100.0
0514.05543.015.0773.0
061.00.06344.00.0
076335.010.00.00.0
086197.00.01.0147.0
096345.00.00.00.0
108.06017.0310.010.0
1136.03815.025.02469.0
121565.0264.04341.0175.0
133762.01177.0830.0576.0
143396.0843.0810.01296.0
154325.0934.0406.0680.0
16966.03452.0946.0981.0
171219.52229.5815.52080.5
PFM
ACGT
010.3440.2540.2580.143
020.4240.1770.1020.297
030.7190.1030.0390.139
040.1250.5830.1180.173
050.0020.8740.0020.122
060.00.01.00.0
070.9980.0020.00.0
080.9770.00.00.023
091.00.00.00.0
100.0010.9480.0490.002
110.0060.6010.0040.389
120.2470.0420.6840.028
130.5930.1860.1310.091
140.5350.1330.1280.204
150.6820.1470.0640.107
160.1520.5440.1490.155
170.1920.3510.1290.328
PWM
ACGT
010.320.0160.033-0.556
020.527-0.343-0.8960.172
031.055-0.884-1.856-0.585
04-0.6880.846-0.749-0.365
05-4.5861.25-4.526-0.717
06-6.211-6.5871.385-6.587
071.384-4.87-6.587-6.587
081.362-6.587-6.211-2.365
091.385-6.587-6.587-6.587
10-5.0491.332-1.627-4.87
11-3.7280.877-4.0680.442
12-0.013-1.7861.006-2.193
130.863-0.298-0.646-1.011
140.76-0.631-0.671-0.202
151.002-0.529-1.359-0.845
16-0.4950.777-0.516-0.48
17-0.2630.34-0.6640.271
Standard thresholds
P-value Threshold
0.001 1.25756
0.0005 2.88126
0.0001 6.22206