| Motif | IRF3.H12INVIVO.1.SM.B |
| Gene (human) | IRF3 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf3 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | B |
| Motif | IRF3.H12INVIVO.1.SM.B |
| Gene (human) | IRF3 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf3 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | B |
| Motif length | 25 |
| Consensus | nddYvGTTTCvnSGAAACYGMMMvn |
| GC content | 49.91% |
| Information content (bits; total / per base) | 21.554 / 0.862 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 1305 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | 7 (46) | 0.734 | 0.791 | 0.574 | 0.67 | 0.666 | 0.711 | 1.624 | 1.862 | 22.906 | 35.102 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 5 experiments | median | 0.663 | 0.689 | 0.565 | 0.591 | 0.527 | 0.548 |
| best | 0.786 | 0.774 | 0.631 | 0.647 | 0.56 | 0.583 | |
| Methyl HT-SELEX, 1 experiments | median | 0.609 | 0.628 | 0.545 | 0.562 | 0.519 | 0.534 |
| best | 0.609 | 0.628 | 0.545 | 0.562 | 0.519 | 0.534 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.7 | 0.697 | 0.596 | 0.606 | 0.543 | 0.56 |
| best | 0.786 | 0.774 | 0.631 | 0.647 | 0.56 | 0.583 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.643 | 0.032 | 0.619 | 0.371 |
| batch 2 | 0.529 | 0.39 | 0.583 | 0.429 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Tryptophan cluster factors {3.5} (TFClass) |
| TF family | IRF {3.5.3} (TFClass) |
| TF subfamily | {3.5.3.0} (TFClass) |
| TFClass ID | TFClass: 3.5.3.0.3 |
| HGNC | HGNC:6118 |
| MGI | MGI:1859179 |
| EntrezGene (human) | GeneID:3661 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:54131 (SSTAR profile) |
| UniProt ID (human) | IRF3_HUMAN |
| UniProt ID (mouse) | IRF3_MOUSE |
| UniProt AC (human) | Q14653 (TFClass) |
| UniProt AC (mouse) | P70671 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 7 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 1 |
| PCM | IRF3.H12INVIVO.1.SM.B.pcm |
| PWM | IRF3.H12INVIVO.1.SM.B.pwm |
| PFM | IRF3.H12INVIVO.1.SM.B.pfm |
| Alignment | IRF3.H12INVIVO.1.SM.B.words.tsv |
| Threshold to P-value map | IRF3.H12INVIVO.1.SM.B.thr |
| Motif in other formats | |
| JASPAR format | IRF3.H12INVIVO.1.SM.B_jaspar_format.txt |
| MEME format | IRF3.H12INVIVO.1.SM.B_meme_format.meme |
| Transfac format | IRF3.H12INVIVO.1.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 257.5 | 197.5 | 443.5 | 406.5 |
| 02 | 371.25 | 162.25 | 174.25 | 597.25 |
| 03 | 218.0 | 118.0 | 462.0 | 507.0 |
| 04 | 134.0 | 941.0 | 51.0 | 179.0 |
| 05 | 386.0 | 212.0 | 590.0 | 117.0 |
| 06 | 78.0 | 98.0 | 1071.0 | 58.0 |
| 07 | 49.0 | 59.0 | 81.0 | 1116.0 |
| 08 | 85.0 | 22.0 | 94.0 | 1104.0 |
| 09 | 121.0 | 45.0 | 50.0 | 1089.0 |
| 10 | 123.0 | 1090.0 | 35.0 | 57.0 |
| 11 | 234.0 | 665.0 | 352.0 | 54.0 |
| 12 | 325.0 | 363.0 | 418.0 | 199.0 |
| 13 | 48.0 | 540.0 | 665.0 | 52.0 |
| 14 | 12.0 | 1.0 | 1290.0 | 2.0 |
| 15 | 1255.0 | 1.0 | 43.0 | 6.0 |
| 16 | 1267.0 | 0.0 | 5.0 | 33.0 |
| 17 | 1288.0 | 2.0 | 6.0 | 9.0 |
| 18 | 0.0 | 1213.0 | 86.0 | 6.0 |
| 19 | 77.0 | 827.0 | 176.0 | 225.0 |
| 20 | 62.0 | 10.0 | 1209.0 | 24.0 |
| 21 | 983.0 | 167.0 | 76.0 | 79.0 |
| 22 | 899.0 | 173.0 | 115.0 | 118.0 |
| 23 | 976.0 | 210.0 | 54.0 | 65.0 |
| 24 | 250.0 | 567.0 | 330.0 | 158.0 |
| 25 | 219.25 | 402.25 | 320.25 | 363.25 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.197 | 0.151 | 0.34 | 0.311 |
| 02 | 0.284 | 0.124 | 0.134 | 0.458 |
| 03 | 0.167 | 0.09 | 0.354 | 0.389 |
| 04 | 0.103 | 0.721 | 0.039 | 0.137 |
| 05 | 0.296 | 0.162 | 0.452 | 0.09 |
| 06 | 0.06 | 0.075 | 0.821 | 0.044 |
| 07 | 0.038 | 0.045 | 0.062 | 0.855 |
| 08 | 0.065 | 0.017 | 0.072 | 0.846 |
| 09 | 0.093 | 0.034 | 0.038 | 0.834 |
| 10 | 0.094 | 0.835 | 0.027 | 0.044 |
| 11 | 0.179 | 0.51 | 0.27 | 0.041 |
| 12 | 0.249 | 0.278 | 0.32 | 0.152 |
| 13 | 0.037 | 0.414 | 0.51 | 0.04 |
| 14 | 0.009 | 0.001 | 0.989 | 0.002 |
| 15 | 0.962 | 0.001 | 0.033 | 0.005 |
| 16 | 0.971 | 0.0 | 0.004 | 0.025 |
| 17 | 0.987 | 0.002 | 0.005 | 0.007 |
| 18 | 0.0 | 0.93 | 0.066 | 0.005 |
| 19 | 0.059 | 0.634 | 0.135 | 0.172 |
| 20 | 0.048 | 0.008 | 0.926 | 0.018 |
| 21 | 0.753 | 0.128 | 0.058 | 0.061 |
| 22 | 0.689 | 0.133 | 0.088 | 0.09 |
| 23 | 0.748 | 0.161 | 0.041 | 0.05 |
| 24 | 0.192 | 0.434 | 0.253 | 0.121 |
| 25 | 0.168 | 0.308 | 0.245 | 0.278 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.235 | -0.498 | 0.306 | 0.219 |
| 02 | 0.129 | -0.693 | -0.622 | 0.602 |
| 03 | -0.4 | -1.007 | 0.346 | 0.439 |
| 04 | -0.882 | 1.056 | -1.827 | -0.596 |
| 05 | 0.167 | -0.428 | 0.59 | -1.016 |
| 06 | -1.414 | -1.19 | 1.185 | -1.702 |
| 07 | -1.865 | -1.686 | -1.377 | 1.226 |
| 08 | -1.33 | -2.624 | -1.231 | 1.215 |
| 09 | -0.983 | -1.947 | -1.846 | 1.202 |
| 10 | -0.966 | 1.202 | -2.188 | -1.719 |
| 11 | -0.33 | 0.709 | 0.076 | -1.771 |
| 12 | -0.004 | 0.106 | 0.247 | -0.491 |
| 13 | -1.885 | 0.502 | 0.709 | -1.808 |
| 14 | -3.169 | -4.766 | 1.371 | -4.46 |
| 15 | 1.343 | -4.766 | -1.991 | -3.74 |
| 16 | 1.353 | -5.209 | -3.877 | -2.244 |
| 17 | 1.369 | -4.46 | -3.74 | -3.414 |
| 18 | -5.209 | 1.309 | -1.318 | -3.74 |
| 19 | -1.426 | 0.927 | -0.613 | -0.369 |
| 20 | -1.637 | -3.326 | 1.306 | -2.543 |
| 21 | 1.099 | -0.664 | -1.439 | -1.401 |
| 22 | 1.01 | -0.63 | -1.033 | -1.007 |
| 23 | 1.092 | -0.438 | -1.771 | -1.592 |
| 24 | -0.265 | 0.55 | 0.011 | -0.719 |
| 25 | -0.395 | 0.208 | -0.018 | 0.107 |
| P-value | Threshold |
|---|---|
| 0.001 | -0.05614 |
| 0.0005 | 1.37221 |
| 0.0001 | 4.39701 |