MotifIRF3.H12INVITRO.1.SM.B
Gene (human)IRF3
(GeneCards)
Gene synonyms (human)
Gene (mouse)Irf3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length23
ConsensusYdSTTTCMhGGAAACbGMdMvnn
GC content48.41%
Information content (bits; total / per base)21.862 / 0.951
Data sourcesHT-SELEX + Methyl-HT-SELEX
Aligned words2036

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Mouse 7 (46) 0.724 0.779 0.536 0.634 0.669 0.711 1.588 1.816 22.61 46.721

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.667 0.69 0.573 0.593 0.533 0.551
best 0.796 0.779 0.64 0.652 0.563 0.586
Methyl HT-SELEX, 1 experiments median 0.617 0.636 0.55 0.567 0.522 0.537
best 0.617 0.636 0.55 0.567 0.522 0.537
Non-Methyl HT-SELEX, 4 experiments median 0.716 0.708 0.606 0.613 0.547 0.564
best 0.796 0.779 0.64 0.652 0.563 0.586

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.63 0.044 0.632 0.371
batch 2 0.419 0.305 0.657 0.473
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classTryptophan cluster factors {3.5} (TFClass)
TF familyIRF {3.5.3} (TFClass)
TF subfamily {3.5.3.0} (TFClass)
TFClass IDTFClass: 3.5.3.0.3
HGNCHGNC:6118
MGIMGI:1859179
EntrezGene (human)GeneID:3661
(SSTAR profile)
EntrezGene (mouse)GeneID:54131
(SSTAR profile)
UniProt ID (human)IRF3_HUMAN
UniProt ID (mouse)IRF3_MOUSE
UniProt AC (human)Q14653
(TFClass)
UniProt AC (mouse)P70671
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 7 mouse
HT-SELEX 4
Methyl-HT-SELEX 1
PCM
ACGT
01260.251323.2592.25360.25
021037.75256.75354.75386.75
03159.0254.01527.096.0
0449.030.0171.01786.0
0557.012.0216.01751.0
06252.021.026.01737.0
07208.01731.020.077.0
08320.01559.0111.046.0
09713.0342.0287.0694.0
1018.0159.01787.072.0
116.01.02027.02.0
122008.01.026.01.0
132021.00.03.012.0
142023.03.05.05.0
1550.01837.0137.012.0
16132.0798.0184.0922.0
17277.04.01740.015.0
181105.0829.063.039.0
19999.0177.0618.0242.0
201108.0684.072.0172.0
21420.0927.0534.0155.0
22404.75595.75341.75693.75
23792.5332.5450.5460.5
PFM
ACGT
010.1280.650.0450.177
020.510.1260.1740.19
030.0780.1250.750.047
040.0240.0150.0840.877
050.0280.0060.1060.86
060.1240.010.0130.853
070.1020.850.010.038
080.1570.7660.0550.023
090.350.1680.1410.341
100.0090.0780.8780.035
110.0030.00.9960.001
120.9860.00.0130.0
130.9930.00.0010.006
140.9940.0010.0020.002
150.0250.9020.0670.006
160.0650.3920.090.453
170.1360.0020.8550.007
180.5430.4070.0310.019
190.4910.0870.3040.119
200.5440.3360.0350.084
210.2060.4550.2620.076
220.1990.2930.1680.341
230.3890.1630.2210.226
PWM
ACGT
01-0.6670.953-1.691-0.344
020.71-0.681-0.359-0.273
03-1.155-0.6911.096-1.652
04-2.306-2.773-1.0831.253
05-2.16-3.604-0.8521.233
06-0.699-3.105-2.9071.225
07-0.891.221-3.149-1.868
08-0.4621.117-1.51-2.367
090.336-0.396-0.570.309
10-3.245-1.1551.253-1.933
11-4.169-5.171.379-4.874
121.37-5.17-2.907-5.17
131.376-5.592-4.646-3.604
141.377-4.646-4.304-4.304
15-2.2871.281-1.302-3.604
16-1.3390.448-1.0110.592
17-0.605-4.461.227-3.409
180.7730.486-2.063-2.525
190.672-1.0490.193-0.739
200.7760.295-1.933-1.078
21-0.1910.5980.048-1.181
22-0.2280.157-0.3970.309
230.441-0.424-0.122-0.1
Standard thresholds
P-value Threshold
0.001 -1.14724
0.0005 0.43066
0.0001 3.76116