MotifIRF3.H12INVITRO.0.PS.A
Gene (human)IRF3
(GeneCards)
Gene synonyms (human)
Gene (mouse)Irf3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length19
ConsensusnbRRAAvSGAAASbRRWMn
GC content44.74%
Information content (bits; total / per base)14.589 / 0.768
Data sourcesChIP-Seq + HT-SELEX
Aligned words5826

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Mouse 7 (46) 0.853 0.906 0.774 0.86 0.861 0.906 3.844 5.365 121.95 197.377

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 5 experiments median 0.703 0.728 0.587 0.614 0.54 0.564
best 0.919 0.919 0.693 0.729 0.579 0.626
Methyl HT-SELEX, 1 experiments median 0.621 0.618 0.561 0.564 0.532 0.538
best 0.621 0.618 0.561 0.564 0.532 0.538
Non-Methyl HT-SELEX, 4 experiments median 0.772 0.792 0.621 0.651 0.556 0.585
best 0.919 0.919 0.693 0.729 0.579 0.626

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.788 0.208 0.685 0.367
batch 2 0.74 0.561 0.666 0.473
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classTryptophan cluster factors {3.5} (TFClass)
TF familyIRF {3.5.3} (TFClass)
TF subfamily {3.5.3.0} (TFClass)
TFClass IDTFClass: 3.5.3.0.3
HGNCHGNC:6118
MGIMGI:1859179
EntrezGene (human)GeneID:3661
(SSTAR profile)
EntrezGene (mouse)GeneID:54131
(SSTAR profile)
UniProt ID (human)IRF3_HUMAN
UniProt ID (mouse)IRF3_MOUSE
UniProt AC (human)Q14653
(TFClass)
UniProt AC (mouse)P70671
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 0 human, 7 mouse
HT-SELEX 4
Methyl-HT-SELEX 1
PCM
ACGT
011570.751472.751529.751252.75
02647.251301.253161.25716.25
031217.0375.03881.0353.0
044231.0241.0928.0426.0
054770.0180.0391.0485.0
064933.0274.0145.0474.0
071383.02306.01440.0697.0
08266.01977.03016.0567.0
097.02.05817.00.0
105603.025.0122.076.0
115551.00.024.0251.0
125491.064.044.0227.0
13370.03582.01574.0300.0
14765.02129.01471.01461.0
15957.0268.04223.0378.0
163914.0665.0749.0498.0
173627.0469.0706.01024.0
183764.5779.5589.5692.5
191264.02259.01338.0965.0
PFM
ACGT
010.270.2530.2630.215
020.1110.2230.5430.123
030.2090.0640.6660.061
040.7260.0410.1590.073
050.8190.0310.0670.083
060.8470.0470.0250.081
070.2370.3960.2470.12
080.0460.3390.5180.097
090.0010.00.9980.0
100.9620.0040.0210.013
110.9530.00.0040.043
120.9420.0110.0080.039
130.0640.6150.270.051
140.1310.3650.2520.251
150.1640.0460.7250.065
160.6720.1140.1290.085
170.6230.0810.1210.176
180.6460.1340.1010.119
190.2170.3880.230.166
PWM
ACGT
010.0750.0110.049-0.15
02-0.809-0.1130.774-0.708
03-0.179-1.3530.979-1.413
041.065-1.792-0.45-1.226
051.185-2.08-1.311-1.097
061.219-1.664-2.294-1.12
07-0.0520.459-0.011-0.735
08-1.6940.3050.727-0.941
09-5.07-5.8581.384-6.512
101.346-3.983-2.464-2.926
111.337-6.512-4.021-1.751
121.326-3.093-3.453-1.851
13-1.3660.8990.077-1.574
14-0.6430.3790.010.003
15-0.419-1.6861.064-1.345
160.988-0.782-0.664-1.07
170.911-1.13-0.723-0.352
180.949-0.624-0.902-0.742
19-0.1420.438-0.085-0.411
Standard thresholds
P-value Threshold
0.001 3.23621
0.0005 4.36466
0.0001 6.68831