| Motif | IRF3.H12INVITRO.0.PS.A |
| Gene (human) | IRF3 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf3 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | IRF3.H12INVITRO.0.PS.A |
| Gene (human) | IRF3 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf3 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 19 |
| Consensus | nbRRAAvSGAAASbRRWMn |
| GC content | 44.74% |
| Information content (bits; total / per base) | 14.589 / 0.768 |
| Data sources | ChIP-Seq + HT-SELEX |
| Aligned words | 5826 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | 7 (46) | 0.853 | 0.906 | 0.774 | 0.86 | 0.861 | 0.906 | 3.844 | 5.365 | 121.95 | 197.377 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 5 experiments | median | 0.703 | 0.728 | 0.587 | 0.614 | 0.54 | 0.564 |
| best | 0.919 | 0.919 | 0.693 | 0.729 | 0.579 | 0.626 | |
| Methyl HT-SELEX, 1 experiments | median | 0.621 | 0.618 | 0.561 | 0.564 | 0.532 | 0.538 |
| best | 0.621 | 0.618 | 0.561 | 0.564 | 0.532 | 0.538 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.772 | 0.792 | 0.621 | 0.651 | 0.556 | 0.585 |
| best | 0.919 | 0.919 | 0.693 | 0.729 | 0.579 | 0.626 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.788 | 0.208 | 0.685 | 0.367 |
| batch 2 | 0.74 | 0.561 | 0.666 | 0.473 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Tryptophan cluster factors {3.5} (TFClass) |
| TF family | IRF {3.5.3} (TFClass) |
| TF subfamily | {3.5.3.0} (TFClass) |
| TFClass ID | TFClass: 3.5.3.0.3 |
| HGNC | HGNC:6118 |
| MGI | MGI:1859179 |
| EntrezGene (human) | GeneID:3661 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:54131 (SSTAR profile) |
| UniProt ID (human) | IRF3_HUMAN |
| UniProt ID (mouse) | IRF3_MOUSE |
| UniProt AC (human) | Q14653 (TFClass) |
| UniProt AC (mouse) | P70671 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 7 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 1 |
| PCM | IRF3.H12INVITRO.0.PS.A.pcm |
| PWM | IRF3.H12INVITRO.0.PS.A.pwm |
| PFM | IRF3.H12INVITRO.0.PS.A.pfm |
| Alignment | IRF3.H12INVITRO.0.PS.A.words.tsv |
| Threshold to P-value map | IRF3.H12INVITRO.0.PS.A.thr |
| Motif in other formats | |
| JASPAR format | IRF3.H12INVITRO.0.PS.A_jaspar_format.txt |
| MEME format | IRF3.H12INVITRO.0.PS.A_meme_format.meme |
| Transfac format | IRF3.H12INVITRO.0.PS.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1570.75 | 1472.75 | 1529.75 | 1252.75 |
| 02 | 647.25 | 1301.25 | 3161.25 | 716.25 |
| 03 | 1217.0 | 375.0 | 3881.0 | 353.0 |
| 04 | 4231.0 | 241.0 | 928.0 | 426.0 |
| 05 | 4770.0 | 180.0 | 391.0 | 485.0 |
| 06 | 4933.0 | 274.0 | 145.0 | 474.0 |
| 07 | 1383.0 | 2306.0 | 1440.0 | 697.0 |
| 08 | 266.0 | 1977.0 | 3016.0 | 567.0 |
| 09 | 7.0 | 2.0 | 5817.0 | 0.0 |
| 10 | 5603.0 | 25.0 | 122.0 | 76.0 |
| 11 | 5551.0 | 0.0 | 24.0 | 251.0 |
| 12 | 5491.0 | 64.0 | 44.0 | 227.0 |
| 13 | 370.0 | 3582.0 | 1574.0 | 300.0 |
| 14 | 765.0 | 2129.0 | 1471.0 | 1461.0 |
| 15 | 957.0 | 268.0 | 4223.0 | 378.0 |
| 16 | 3914.0 | 665.0 | 749.0 | 498.0 |
| 17 | 3627.0 | 469.0 | 706.0 | 1024.0 |
| 18 | 3764.5 | 779.5 | 589.5 | 692.5 |
| 19 | 1264.0 | 2259.0 | 1338.0 | 965.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.27 | 0.253 | 0.263 | 0.215 |
| 02 | 0.111 | 0.223 | 0.543 | 0.123 |
| 03 | 0.209 | 0.064 | 0.666 | 0.061 |
| 04 | 0.726 | 0.041 | 0.159 | 0.073 |
| 05 | 0.819 | 0.031 | 0.067 | 0.083 |
| 06 | 0.847 | 0.047 | 0.025 | 0.081 |
| 07 | 0.237 | 0.396 | 0.247 | 0.12 |
| 08 | 0.046 | 0.339 | 0.518 | 0.097 |
| 09 | 0.001 | 0.0 | 0.998 | 0.0 |
| 10 | 0.962 | 0.004 | 0.021 | 0.013 |
| 11 | 0.953 | 0.0 | 0.004 | 0.043 |
| 12 | 0.942 | 0.011 | 0.008 | 0.039 |
| 13 | 0.064 | 0.615 | 0.27 | 0.051 |
| 14 | 0.131 | 0.365 | 0.252 | 0.251 |
| 15 | 0.164 | 0.046 | 0.725 | 0.065 |
| 16 | 0.672 | 0.114 | 0.129 | 0.085 |
| 17 | 0.623 | 0.081 | 0.121 | 0.176 |
| 18 | 0.646 | 0.134 | 0.101 | 0.119 |
| 19 | 0.217 | 0.388 | 0.23 | 0.166 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.075 | 0.011 | 0.049 | -0.15 |
| 02 | -0.809 | -0.113 | 0.774 | -0.708 |
| 03 | -0.179 | -1.353 | 0.979 | -1.413 |
| 04 | 1.065 | -1.792 | -0.45 | -1.226 |
| 05 | 1.185 | -2.08 | -1.311 | -1.097 |
| 06 | 1.219 | -1.664 | -2.294 | -1.12 |
| 07 | -0.052 | 0.459 | -0.011 | -0.735 |
| 08 | -1.694 | 0.305 | 0.727 | -0.941 |
| 09 | -5.07 | -5.858 | 1.384 | -6.512 |
| 10 | 1.346 | -3.983 | -2.464 | -2.926 |
| 11 | 1.337 | -6.512 | -4.021 | -1.751 |
| 12 | 1.326 | -3.093 | -3.453 | -1.851 |
| 13 | -1.366 | 0.899 | 0.077 | -1.574 |
| 14 | -0.643 | 0.379 | 0.01 | 0.003 |
| 15 | -0.419 | -1.686 | 1.064 | -1.345 |
| 16 | 0.988 | -0.782 | -0.664 | -1.07 |
| 17 | 0.911 | -1.13 | -0.723 | -0.352 |
| 18 | 0.949 | -0.624 | -0.902 | -0.742 |
| 19 | -0.142 | 0.438 | -0.085 | -0.411 |
| P-value | Threshold |
|---|---|
| 0.001 | 3.23621 |
| 0.0005 | 4.36466 |
| 0.0001 | 6.68831 |