| Motif | IRF3.H12CORE.1.SM.B |
| Gene (human) | IRF3 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf3 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 1 |
| Quality | B |
| Motif | IRF3.H12CORE.1.SM.B |
| Gene (human) | IRF3 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf3 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 1 |
| Quality | B |
| Motif length | 23 |
| Consensus | YdSTTTCMhGGAAACbGMdMvnn |
| GC content | 48.41% |
| Information content (bits; total / per base) | 21.862 / 0.951 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 2036 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | 7 (46) | 0.724 | 0.779 | 0.536 | 0.634 | 0.669 | 0.711 | 1.588 | 1.816 | 22.61 | 46.721 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 5 experiments | median | 0.667 | 0.69 | 0.573 | 0.593 | 0.533 | 0.551 |
| best | 0.796 | 0.779 | 0.64 | 0.652 | 0.563 | 0.586 | |
| Methyl HT-SELEX, 1 experiments | median | 0.617 | 0.636 | 0.55 | 0.567 | 0.522 | 0.537 |
| best | 0.617 | 0.636 | 0.55 | 0.567 | 0.522 | 0.537 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.716 | 0.708 | 0.606 | 0.613 | 0.547 | 0.564 |
| best | 0.796 | 0.779 | 0.64 | 0.652 | 0.563 | 0.586 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 1 | 0.63 | 0.044 | 0.632 | 0.371 |
| batch 2 | 0.419 | 0.305 | 0.657 | 0.473 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Tryptophan cluster factors {3.5} (TFClass) |
| TF family | IRF {3.5.3} (TFClass) |
| TF subfamily | {3.5.3.0} (TFClass) |
| TFClass ID | TFClass: 3.5.3.0.3 |
| HGNC | HGNC:6118 |
| MGI | MGI:1859179 |
| EntrezGene (human) | GeneID:3661 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:54131 (SSTAR profile) |
| UniProt ID (human) | IRF3_HUMAN |
| UniProt ID (mouse) | IRF3_MOUSE |
| UniProt AC (human) | Q14653 (TFClass) |
| UniProt AC (mouse) | P70671 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 7 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 1 |
| PCM | IRF3.H12CORE.1.SM.B.pcm |
| PWM | IRF3.H12CORE.1.SM.B.pwm |
| PFM | IRF3.H12CORE.1.SM.B.pfm |
| Alignment | IRF3.H12CORE.1.SM.B.words.tsv |
| Threshold to P-value map | IRF3.H12CORE.1.SM.B.thr |
| Motif in other formats | |
| JASPAR format | IRF3.H12CORE.1.SM.B_jaspar_format.txt |
| MEME format | IRF3.H12CORE.1.SM.B_meme_format.meme |
| Transfac format | IRF3.H12CORE.1.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 260.25 | 1323.25 | 92.25 | 360.25 |
| 02 | 1037.75 | 256.75 | 354.75 | 386.75 |
| 03 | 159.0 | 254.0 | 1527.0 | 96.0 |
| 04 | 49.0 | 30.0 | 171.0 | 1786.0 |
| 05 | 57.0 | 12.0 | 216.0 | 1751.0 |
| 06 | 252.0 | 21.0 | 26.0 | 1737.0 |
| 07 | 208.0 | 1731.0 | 20.0 | 77.0 |
| 08 | 320.0 | 1559.0 | 111.0 | 46.0 |
| 09 | 713.0 | 342.0 | 287.0 | 694.0 |
| 10 | 18.0 | 159.0 | 1787.0 | 72.0 |
| 11 | 6.0 | 1.0 | 2027.0 | 2.0 |
| 12 | 2008.0 | 1.0 | 26.0 | 1.0 |
| 13 | 2021.0 | 0.0 | 3.0 | 12.0 |
| 14 | 2023.0 | 3.0 | 5.0 | 5.0 |
| 15 | 50.0 | 1837.0 | 137.0 | 12.0 |
| 16 | 132.0 | 798.0 | 184.0 | 922.0 |
| 17 | 277.0 | 4.0 | 1740.0 | 15.0 |
| 18 | 1105.0 | 829.0 | 63.0 | 39.0 |
| 19 | 999.0 | 177.0 | 618.0 | 242.0 |
| 20 | 1108.0 | 684.0 | 72.0 | 172.0 |
| 21 | 420.0 | 927.0 | 534.0 | 155.0 |
| 22 | 404.75 | 595.75 | 341.75 | 693.75 |
| 23 | 792.5 | 332.5 | 450.5 | 460.5 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.128 | 0.65 | 0.045 | 0.177 |
| 02 | 0.51 | 0.126 | 0.174 | 0.19 |
| 03 | 0.078 | 0.125 | 0.75 | 0.047 |
| 04 | 0.024 | 0.015 | 0.084 | 0.877 |
| 05 | 0.028 | 0.006 | 0.106 | 0.86 |
| 06 | 0.124 | 0.01 | 0.013 | 0.853 |
| 07 | 0.102 | 0.85 | 0.01 | 0.038 |
| 08 | 0.157 | 0.766 | 0.055 | 0.023 |
| 09 | 0.35 | 0.168 | 0.141 | 0.341 |
| 10 | 0.009 | 0.078 | 0.878 | 0.035 |
| 11 | 0.003 | 0.0 | 0.996 | 0.001 |
| 12 | 0.986 | 0.0 | 0.013 | 0.0 |
| 13 | 0.993 | 0.0 | 0.001 | 0.006 |
| 14 | 0.994 | 0.001 | 0.002 | 0.002 |
| 15 | 0.025 | 0.902 | 0.067 | 0.006 |
| 16 | 0.065 | 0.392 | 0.09 | 0.453 |
| 17 | 0.136 | 0.002 | 0.855 | 0.007 |
| 18 | 0.543 | 0.407 | 0.031 | 0.019 |
| 19 | 0.491 | 0.087 | 0.304 | 0.119 |
| 20 | 0.544 | 0.336 | 0.035 | 0.084 |
| 21 | 0.206 | 0.455 | 0.262 | 0.076 |
| 22 | 0.199 | 0.293 | 0.168 | 0.341 |
| 23 | 0.389 | 0.163 | 0.221 | 0.226 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.667 | 0.953 | -1.691 | -0.344 |
| 02 | 0.71 | -0.681 | -0.359 | -0.273 |
| 03 | -1.155 | -0.691 | 1.096 | -1.652 |
| 04 | -2.306 | -2.773 | -1.083 | 1.253 |
| 05 | -2.16 | -3.604 | -0.852 | 1.233 |
| 06 | -0.699 | -3.105 | -2.907 | 1.225 |
| 07 | -0.89 | 1.221 | -3.149 | -1.868 |
| 08 | -0.462 | 1.117 | -1.51 | -2.367 |
| 09 | 0.336 | -0.396 | -0.57 | 0.309 |
| 10 | -3.245 | -1.155 | 1.253 | -1.933 |
| 11 | -4.169 | -5.17 | 1.379 | -4.874 |
| 12 | 1.37 | -5.17 | -2.907 | -5.17 |
| 13 | 1.376 | -5.592 | -4.646 | -3.604 |
| 14 | 1.377 | -4.646 | -4.304 | -4.304 |
| 15 | -2.287 | 1.281 | -1.302 | -3.604 |
| 16 | -1.339 | 0.448 | -1.011 | 0.592 |
| 17 | -0.605 | -4.46 | 1.227 | -3.409 |
| 18 | 0.773 | 0.486 | -2.063 | -2.525 |
| 19 | 0.672 | -1.049 | 0.193 | -0.739 |
| 20 | 0.776 | 0.295 | -1.933 | -1.078 |
| 21 | -0.191 | 0.598 | 0.048 | -1.181 |
| 22 | -0.228 | 0.157 | -0.397 | 0.309 |
| 23 | 0.441 | -0.424 | -0.122 | -0.1 |
| P-value | Threshold |
|---|---|
| 0.001 | -1.14724 |
| 0.0005 | 0.43066 |
| 0.0001 | 3.76116 |