| Motif | IRF2.H12RSNP.0.PSM.A |
| Gene (human) | IRF2 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf2 |
| Gene synonyms (mouse) | |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 0 |
| Quality | A |
| Motif | IRF2.H12RSNP.0.PSM.A |
| Gene (human) | IRF2 (GeneCards) |
| Gene synonyms (human) | |
| Gene (mouse) | Irf2 |
| Gene synonyms (mouse) | |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 0 |
| Quality | A |
| Motif length | 21 |
| Consensus | RRWvhRAAAShGAAAShRRdh |
| GC content | 33.15% |
| Information content (bits; total / per base) | 19.954 / 0.95 |
| Data sources | ChIP-Seq + HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 781 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 5 (30) | 0.848 | 0.952 | 0.794 | 0.911 | 0.921 | 0.981 | 6.264 | 8.077 | 244.201 | 580.432 |
| Mouse | 4 (24) | 0.776 | 0.931 | 0.723 | 0.898 | 0.852 | 0.967 | 5.889 | 8.001 | 67.829 | 260.796 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.993 | 0.988 | 0.981 | 0.973 | 0.929 | 0.918 |
| best | 0.997 | 0.995 | 0.986 | 0.982 | 0.942 | 0.925 | |
| Methyl HT-SELEX, 1 experiments | median | 0.997 | 0.995 | 0.986 | 0.982 | 0.915 | 0.911 |
| best | 0.997 | 0.995 | 0.986 | 0.982 | 0.915 | 0.911 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 0.988 | 0.98 | 0.977 | 0.964 | 0.942 | 0.925 |
| best | 0.988 | 0.98 | 0.977 | 0.964 | 0.942 | 0.925 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.915 | 0.847 | 0.855 | 0.638 |
| TF superclass | Helix-turn-helix domains {3} (TFClass) |
| TF class | Tryptophan cluster factors {3.5} (TFClass) |
| TF family | IRF {3.5.3} (TFClass) |
| TF subfamily | {3.5.3.0} (TFClass) |
| TFClass ID | TFClass: 3.5.3.0.2 |
| HGNC | HGNC:6117 |
| MGI | MGI:96591 |
| EntrezGene (human) | GeneID:3660 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:16363 (SSTAR profile) |
| UniProt ID (human) | IRF2_HUMAN |
| UniProt ID (mouse) | IRF2_MOUSE |
| UniProt AC (human) | P14316 (TFClass) |
| UniProt AC (mouse) | P23906 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 5 human, 4 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| PCM | IRF2.H12RSNP.0.PSM.A.pcm |
| PWM | IRF2.H12RSNP.0.PSM.A.pwm |
| PFM | IRF2.H12RSNP.0.PSM.A.pfm |
| Alignment | IRF2.H12RSNP.0.PSM.A.words.tsv |
| Threshold to P-value map | IRF2.H12RSNP.0.PSM.A.thr |
| Motif in other formats | |
| JASPAR format | IRF2.H12RSNP.0.PSM.A_jaspar_format.txt |
| MEME format | IRF2.H12RSNP.0.PSM.A_meme_format.meme |
| Transfac format | IRF2.H12RSNP.0.PSM.A_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 524.0 | 47.0 | 171.0 | 39.0 |
| 02 | 624.0 | 44.0 | 61.0 | 52.0 |
| 03 | 625.0 | 39.0 | 46.0 | 71.0 |
| 04 | 226.0 | 240.0 | 225.0 | 90.0 |
| 05 | 245.0 | 250.0 | 75.0 | 211.0 |
| 06 | 227.0 | 30.0 | 517.0 | 7.0 |
| 07 | 771.0 | 0.0 | 10.0 | 0.0 |
| 08 | 776.0 | 0.0 | 4.0 | 1.0 |
| 09 | 776.0 | 0.0 | 0.0 | 5.0 |
| 10 | 84.0 | 343.0 | 349.0 | 5.0 |
| 11 | 151.0 | 231.0 | 17.0 | 382.0 |
| 12 | 179.0 | 4.0 | 595.0 | 3.0 |
| 13 | 768.0 | 1.0 | 11.0 | 1.0 |
| 14 | 778.0 | 0.0 | 2.0 | 1.0 |
| 15 | 776.0 | 0.0 | 4.0 | 1.0 |
| 16 | 21.0 | 357.0 | 394.0 | 9.0 |
| 17 | 127.0 | 339.0 | 33.0 | 282.0 |
| 18 | 420.0 | 64.0 | 238.0 | 59.0 |
| 19 | 494.0 | 63.0 | 158.0 | 66.0 |
| 20 | 449.0 | 100.0 | 130.0 | 102.0 |
| 21 | 414.0 | 138.0 | 107.0 | 122.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.671 | 0.06 | 0.219 | 0.05 |
| 02 | 0.799 | 0.056 | 0.078 | 0.067 |
| 03 | 0.8 | 0.05 | 0.059 | 0.091 |
| 04 | 0.289 | 0.307 | 0.288 | 0.115 |
| 05 | 0.314 | 0.32 | 0.096 | 0.27 |
| 06 | 0.291 | 0.038 | 0.662 | 0.009 |
| 07 | 0.987 | 0.0 | 0.013 | 0.0 |
| 08 | 0.994 | 0.0 | 0.005 | 0.001 |
| 09 | 0.994 | 0.0 | 0.0 | 0.006 |
| 10 | 0.108 | 0.439 | 0.447 | 0.006 |
| 11 | 0.193 | 0.296 | 0.022 | 0.489 |
| 12 | 0.229 | 0.005 | 0.762 | 0.004 |
| 13 | 0.983 | 0.001 | 0.014 | 0.001 |
| 14 | 0.996 | 0.0 | 0.003 | 0.001 |
| 15 | 0.994 | 0.0 | 0.005 | 0.001 |
| 16 | 0.027 | 0.457 | 0.504 | 0.012 |
| 17 | 0.163 | 0.434 | 0.042 | 0.361 |
| 18 | 0.538 | 0.082 | 0.305 | 0.076 |
| 19 | 0.633 | 0.081 | 0.202 | 0.085 |
| 20 | 0.575 | 0.128 | 0.166 | 0.131 |
| 21 | 0.53 | 0.177 | 0.137 | 0.156 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.982 | -1.398 | -0.131 | -1.577 |
| 02 | 1.156 | -1.461 | -1.145 | -1.3 |
| 03 | 1.158 | -1.577 | -1.419 | -0.997 |
| 04 | 0.145 | 0.205 | 0.141 | -0.765 |
| 05 | 0.225 | 0.245 | -0.943 | 0.077 |
| 06 | 0.149 | -1.828 | 0.968 | -3.123 |
| 07 | 1.367 | -4.773 | -2.826 | -4.773 |
| 08 | 1.374 | -4.773 | -3.548 | -4.303 |
| 09 | 1.374 | -4.773 | -4.773 | -3.386 |
| 10 | -0.832 | 0.56 | 0.577 | -3.386 |
| 11 | -0.255 | 0.167 | -2.356 | 0.667 |
| 12 | -0.086 | -3.548 | 1.109 | -3.743 |
| 13 | 1.363 | -4.303 | -2.744 | -4.303 |
| 14 | 1.376 | -4.773 | -3.984 | -4.303 |
| 15 | 1.374 | -4.773 | -3.548 | -4.303 |
| 16 | -2.162 | 0.6 | 0.698 | -2.916 |
| 17 | -0.426 | 0.548 | -1.737 | 0.365 |
| 18 | 0.761 | -1.098 | 0.196 | -1.177 |
| 19 | 0.923 | -1.114 | -0.21 | -1.068 |
| 20 | 0.828 | -0.661 | -0.403 | -0.642 |
| 21 | 0.747 | -0.344 | -0.595 | -0.465 |
| P-value | Threshold |
|---|---|
| 0.001 | -0.29584 |
| 0.0005 | 1.25511 |
| 0.0001 | 4.51896 |