MotifHXB8.H12CORE.0.PSM.A
Gene (human)HOXB8
(GeneCards)
Gene synonyms (human)HOX2D
Gene (mouse)Hoxb8
Gene synonyms (mouse)Hox-2.4, Hoxb-8
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length12
ConsensusnhvbTAATKRbn
GC content36.95%
Information content (bits; total / per base)10.558 / 0.88
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9673

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (5) 0.761 0.786 0.629 0.649 0.64 0.667 1.552 1.623 27.252 42.301

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.934 0.898 0.895 0.854 0.834 0.795
best 0.953 0.925 0.924 0.889 0.869 0.833
Methyl HT-SELEX, 1 experiments median 0.915 0.871 0.866 0.819 0.799 0.758
best 0.915 0.871 0.866 0.819 0.799 0.758
Non-Methyl HT-SELEX, 1 experiments median 0.953 0.925 0.924 0.889 0.869 0.833
best 0.953 0.925 0.924 0.889 0.869 0.833
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyHOX-related {3.1.1} (TFClass)
TF subfamilyHOX8 {3.1.1.7} (TFClass)
TFClass IDTFClass: 3.1.1.7.1
HGNCHGNC:5119
MGIMGI:96189
EntrezGene (human)GeneID:3218
(SSTAR profile)
EntrezGene (mouse)GeneID:15416
(SSTAR profile)
UniProt ID (human)HXB8_HUMAN
UniProt ID (mouse)HXB8_MOUSE
UniProt AC (human)P17481
(TFClass)
UniProt AC (mouse)P09632
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 0 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
012482.52356.52423.52410.5
021873.754139.751652.752006.75
032781.02582.03678.0632.0
041080.01454.01651.05488.0
050.05.01.09667.0
069673.00.00.00.0
079673.00.00.00.0
080.0102.01.09570.0
0924.070.04949.04630.0
104144.0119.04925.0485.0
11861.755643.751831.751335.75
122132.253146.252159.252235.25
PFM
ACGT
010.2570.2440.2510.249
020.1940.4280.1710.207
030.2880.2670.380.065
040.1120.150.1710.567
050.00.0010.00.999
061.00.00.00.0
071.00.00.00.0
080.00.0110.00.989
090.0020.0070.5120.479
100.4280.0120.5090.05
110.0890.5830.1890.138
120.220.3250.2230.231
PWM
ACGT
010.026-0.0260.002-0.003
02-0.2550.537-0.38-0.186
030.140.0650.419-1.339
04-0.805-0.508-0.3810.819
05-6.961-5.805-6.61.385
061.386-6.961-6.961-6.961
071.386-6.961-6.961-6.961
08-6.961-3.145-6.61.375
09-4.522-3.5110.7160.649
100.538-2.9940.711-1.603
11-1.030.847-0.277-0.593
12-0.1260.263-0.113-0.079
Standard thresholds
P-value Threshold
0.001 4.753685
0.0005 6.030275
0.0001 7.65123