HSFY1.H12CORE.2.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSFY1.H12CORE.2.M.B
Gene (human)	HSFY1 (GeneCards)
Gene synonyms (human)	HSFY2, HSF2L, HSFY, HSF2L, HSFY
Gene (mouse)
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	19
Consensus	nSRTTCbWWhSvTYSbWhn
GC content	42.73%
Information content (bits; total / per base)	12.586 / 0.662
Data sources	Methyl-HT-SELEX
Aligned words	2467

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.928	0.929	0.768	0.779	0.646	0.676
Overall, 6 experiments	best	1.0	1.0	0.992	0.992	0.824	0.849
Methyl HT-SELEX, 2 experiments	median	0.873	0.88	0.678	0.707	0.585	0.619
Methyl HT-SELEX, 2 experiments	best	0.892	0.901	0.682	0.716	0.587	0.622
Non-Methyl HT-SELEX, 4 experiments	median	0.982	0.978	0.869	0.868	0.714	0.737
Non-Methyl HT-SELEX, 4 experiments	best	1.0	1.0	0.992	0.992	0.824	0.849

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.8
HGNC	HGNC:18568 HGNC:23950
MGI
EntrezGene (human)	GeneID:159119 (SSTAR profile) GeneID:86614 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	HSFY1_HUMAN
UniProt ID (mouse)
UniProt AC (human)	Q96LI6 (TFClass)
UniProt AC (mouse)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	HSFY1.H12CORE.2.M.B.pcm
PWM	HSFY1.H12CORE.2.M.B.pwm
PFM	HSFY1.H12CORE.2.M.B.pfm
Alignment	HSFY1.H12CORE.2.M.B.words.tsv
Threshold to P-value map	HSFY1.H12CORE.2.M.B.thr
Motif in other formats
JASPAR format	HSFY1.H12CORE.2.M.B_jaspar_format.txt
MEME format	HSFY1.H12CORE.2.M.B_meme_format.meme
Transfac format	HSFY1.H12CORE.2.M.B_transfac_format.txt
Homer format	HSFY1.H12CORE.2.M.B_homer_format_0.001.txt HSFY1.H12CORE.2.M.B_homer_format_0.0005.txt HSFY1.H12CORE.2.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	732.25	448.25	876.25	410.25
02	235.0	1610.0	344.0	278.0
03	1210.0	105.0	1118.0	34.0
04	45.0	130.0	10.0	2282.0
05	46.0	51.0	66.0	2304.0
06	29.0	2373.0	44.0	21.0
07	14.0	826.0	802.0	825.0
08	1936.0	151.0	84.0	296.0
09	1403.0	237.0	78.0	749.0
10	952.0	414.0	372.0	729.0
11	265.0	1567.0	396.0	239.0
12	1042.0	204.0	1052.0	169.0
13	159.0	211.0	100.0	1997.0
14	171.0	199.0	171.0	1926.0
15	144.0	1984.0	202.0	137.0
16	185.0	814.0	575.0	893.0
17	1483.0	281.0	241.0	462.0
18	789.5	589.5	172.5	915.5
19	610.75	610.75	517.75	727.75

PFM

	A	C	G	T
01	0.297	0.182	0.355	0.166
02	0.095	0.653	0.139	0.113
03	0.49	0.043	0.453	0.014
04	0.018	0.053	0.004	0.925
05	0.019	0.021	0.027	0.934
06	0.012	0.962	0.018	0.009
07	0.006	0.335	0.325	0.334
08	0.785	0.061	0.034	0.12
09	0.569	0.096	0.032	0.304
10	0.386	0.168	0.151	0.296
11	0.107	0.635	0.161	0.097
12	0.422	0.083	0.426	0.069
13	0.064	0.086	0.041	0.809
14	0.069	0.081	0.069	0.781
15	0.058	0.804	0.082	0.056
16	0.075	0.33	0.233	0.362
17	0.601	0.114	0.098	0.187
18	0.32	0.239	0.07	0.371
19	0.248	0.248	0.21	0.295

PWM

	A	C	G	T
01	0.171	-0.318	0.35	-0.406
02	-0.96	0.958	-0.581	-0.793
03	0.672	-1.755	0.593	-2.845
04	-2.578	-1.545	-3.947	1.306
05	-2.557	-2.458	-2.209	1.316
06	-2.995	1.345	-2.6	-3.294
07	-3.658	0.291	0.262	0.29
08	1.142	-1.397	-1.974	-0.731
09	0.82	-0.951	-2.046	0.194
10	0.433	-0.397	-0.503	0.167
11	-0.841	0.931	-0.441	-0.943
12	0.523	-1.1	0.533	-1.286
13	-1.347	-1.067	-1.803	1.173
14	-1.275	-1.125	-1.275	1.137
15	-1.444	1.166	-1.11	-1.493
16	-1.197	0.277	-0.07	0.369
17	0.876	-0.782	-0.935	-0.288
18	0.246	-0.045	-1.266	0.394
19	-0.01	-0.01	-0.174	0.165

Standard thresholds

P-value	Threshold
0.001	4.04406
0.0005	5.00101
0.0001	7.00116