HSF5.H12RSNP.0.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF5.H12RSNP.0.M.C
Gene (human)	HSF5 (GeneCards)
Gene synonyms (human)	HSTF5
Gene (mouse)	Hsf5
Gene synonyms (mouse)	Gm739
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	C

Motif length	14
Consensus	nbWACATTCCAnnn
GC content	41.74%
Information content (bits; total / per base)	13.845 / 0.989
Data sources	Methyl-HT-SELEX
Aligned words	8666

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.971	0.957	0.919	0.905	0.843	0.836
Overall, 2 experiments	best	0.995	0.992	0.988	0.983	0.957	0.947
Methyl HT-SELEX, 1 experiments	median	0.995	0.992	0.988	0.983	0.957	0.947
Methyl HT-SELEX, 1 experiments	best	0.995	0.992	0.988	0.983	0.957	0.947
Non-Methyl HT-SELEX, 1 experiments	median	0.946	0.921	0.85	0.827	0.729	0.725
Non-Methyl HT-SELEX, 1 experiments	best	0.946	0.921	0.85	0.827	0.729	0.725

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.748	0.376	0.693	0.542

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.5
HGNC	HGNC:26862
MGI	MGI:2685585
EntrezGene (human)	GeneID:124535 (SSTAR profile)
EntrezGene (mouse)	GeneID:327992 (SSTAR profile)
UniProt ID (human)	HSF5_HUMAN
UniProt ID (mouse)	HSF5_MOUSE
UniProt AC (human)	Q4G112 (TFClass)
UniProt AC (mouse)	Q5ND04 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	HSF5.H12RSNP.0.M.C.pcm
PWM	HSF5.H12RSNP.0.M.C.pwm
PFM	HSF5.H12RSNP.0.M.C.pfm
Alignment	HSF5.H12RSNP.0.M.C.words.tsv
Threshold to P-value map	HSF5.H12RSNP.0.M.C.thr
Motif in other formats
JASPAR format	HSF5.H12RSNP.0.M.C_jaspar_format.txt
MEME format	HSF5.H12RSNP.0.M.C_meme_format.meme
Transfac format	HSF5.H12RSNP.0.M.C_transfac_format.txt
Homer format	HSF5.H12RSNP.0.M.C_homer_format_0.001.txt HSF5.H12RSNP.0.M.C_homer_format_0.0005.txt HSF5.H12RSNP.0.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1685.75	2652.75	2196.75	2130.75
02	676.25	3515.25	2590.25	1884.25
03	6537.0	651.0	552.0	926.0
04	7642.0	56.0	954.0	14.0
05	55.0	8551.0	38.0	22.0
06	7170.0	0.0	1496.0	0.0
07	0.0	0.0	0.0	8666.0
08	0.0	0.0	0.0	8666.0
09	0.0	8666.0	0.0	0.0
10	1.0	4637.0	0.0	4028.0
11	5688.0	8.0	2929.0	41.0
12	2185.0	1627.0	1640.0	3214.0
13	3245.5	1789.5	1665.5	1965.5
14	2654.25	2673.25	1749.25	1589.25

PFM

	A	C	G	T
01	0.195	0.306	0.253	0.246
02	0.078	0.406	0.299	0.217
03	0.754	0.075	0.064	0.107
04	0.882	0.006	0.11	0.002
05	0.006	0.987	0.004	0.003
06	0.827	0.0	0.173	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	0.0	1.0
09	0.0	1.0	0.0	0.0
10	0.0	0.535	0.0	0.465
11	0.656	0.001	0.338	0.005
12	0.252	0.188	0.189	0.371
13	0.375	0.206	0.192	0.227
14	0.306	0.308	0.202	0.183

PWM

	A	C	G	T
01	-0.251	0.202	0.014	-0.017
02	-1.162	0.484	0.178	-0.139
03	1.104	-1.2	-1.364	-0.849
04	1.26	-3.617	-0.819	-4.893
05	-3.634	1.372	-3.986	-4.493
06	1.196	-6.864	-0.37	-6.864
07	-6.864	-6.864	-6.864	1.386
08	-6.864	-6.864	-6.864	1.386
09	-6.864	1.386	-6.864	-6.864
10	-6.498	0.76	-6.864	0.62
11	0.965	-5.353	0.301	-3.915
12	0.008	-0.286	-0.278	0.394
13	0.404	-0.191	-0.263	-0.097
14	0.203	0.21	-0.214	-0.309

Standard thresholds

P-value	Threshold
0.001	1.50801
0.0005	3.06776
0.0001	7.00906