HSF5.H12CORE.1.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF5.H12CORE.1.S.C
Gene (human)	HSF5 (GeneCards)
Gene synonyms (human)	HSTF5
Gene (mouse)	Hsf5
Gene synonyms (mouse)	Gm739
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	12
Consensus	nbhRCGTTCbRh
GC content	46.94%
Information content (bits; total / per base)	11.767 / 0.981
Data sources	HT-SELEX
Aligned words	8968

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.981	0.97	0.942	0.927	0.852	0.846
Overall, 2 experiments	best	0.987	0.978	0.976	0.963	0.936	0.919
Methyl HT-SELEX, 1 experiments	median	0.987	0.978	0.976	0.963	0.936	0.919
Methyl HT-SELEX, 1 experiments	best	0.987	0.978	0.976	0.963	0.936	0.919
Non-Methyl HT-SELEX, 1 experiments	median	0.975	0.962	0.908	0.891	0.768	0.772
Non-Methyl HT-SELEX, 1 experiments	best	0.975	0.962	0.908	0.891	0.768	0.772

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.747	0.421	0.747	0.612

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.5
HGNC	HGNC:26862
MGI	MGI:2685585
EntrezGene (human)	GeneID:124535 (SSTAR profile)
EntrezGene (mouse)	GeneID:327992 (SSTAR profile)
UniProt ID (human)	HSF5_HUMAN
UniProt ID (mouse)	HSF5_MOUSE
UniProt AC (human)	Q4G112 (TFClass)
UniProt AC (mouse)	Q5ND04 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	HSF5.H12CORE.1.S.C.pcm
PWM	HSF5.H12CORE.1.S.C.pwm
PFM	HSF5.H12CORE.1.S.C.pfm
Alignment	HSF5.H12CORE.1.S.C.words.tsv
Threshold to P-value map	HSF5.H12CORE.1.S.C.thr
Motif in other formats
JASPAR format	HSF5.H12CORE.1.S.C_jaspar_format.txt
MEME format	HSF5.H12CORE.1.S.C_meme_format.meme
Transfac format	HSF5.H12CORE.1.S.C_transfac_format.txt
Homer format	HSF5.H12CORE.1.S.C_homer_format_0.001.txt HSF5.H12CORE.1.S.C_homer_format_0.0005.txt HSF5.H12CORE.1.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1689.5	2726.5	2196.5	2355.5
02	1011.25	3495.25	2115.25	2346.25
03	4629.0	1789.0	835.0	1715.0
04	6658.0	269.0	1810.0	231.0
05	54.0	8657.0	69.0	188.0
06	1759.0	9.0	7200.0	0.0
07	0.0	1.0	0.0	8967.0
08	0.0	0.0	0.0	8968.0
09	5.0	8962.0	1.0	0.0
10	17.0	3220.0	2590.0	3141.0
11	7036.5	445.5	1097.5	388.5
12	3140.75	1756.75	1271.75	2798.75

PFM

	A	C	G	T
01	0.188	0.304	0.245	0.263
02	0.113	0.39	0.236	0.262
03	0.516	0.199	0.093	0.191
04	0.742	0.03	0.202	0.026
05	0.006	0.965	0.008	0.021
06	0.196	0.001	0.803	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	0.0	1.0
09	0.001	0.999	0.0	0.0
10	0.002	0.359	0.289	0.35
11	0.785	0.05	0.122	0.043
12	0.35	0.196	0.142	0.312

PWM

	A	C	G	T
01	-0.283	0.195	-0.02	0.049
02	-0.795	0.444	-0.058	0.045
03	0.724	-0.225	-0.986	-0.268
04	1.088	-2.113	-0.214	-2.264
05	-3.686	1.35	-3.45	-2.468
06	-0.242	-5.294	1.166	-6.894
07	-6.894	-6.53	-6.894	1.385
08	-6.894	-6.894	-6.894	1.386
09	-5.732	1.385	-6.53	-6.894
10	-4.757	0.362	0.144	0.337
11	1.143	-1.612	-0.713	-1.748
12	0.337	-0.244	-0.566	0.222

Standard thresholds

P-value	Threshold
0.001	3.83998
0.0005	5.264665
0.0001	7.594505