HSF5.H12CORE.0.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF5.H12CORE.0.M.C
Gene (human)	HSF5 (GeneCards)
Gene synonyms (human)	HSTF5
Gene (mouse)	Hsf5
Gene synonyms (mouse)	Gm739
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	C

Motif length	12
Consensus	nbWACATTCCRn
GC content	41.64%
Information content (bits; total / per base)	13.418 / 1.118
Data sources	Methyl-HT-SELEX
Aligned words	8117

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.97	0.954	0.921	0.906	0.844	0.837
Overall, 2 experiments	best	0.995	0.992	0.988	0.983	0.956	0.946
Methyl HT-SELEX, 1 experiments	median	0.995	0.992	0.988	0.983	0.956	0.946
Methyl HT-SELEX, 1 experiments	best	0.995	0.992	0.988	0.983	0.956	0.946
Non-Methyl HT-SELEX, 1 experiments	median	0.944	0.916	0.855	0.828	0.732	0.727
Non-Methyl HT-SELEX, 1 experiments	best	0.944	0.916	0.855	0.828	0.732	0.727

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.699	0.347	0.695	0.553

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.5
HGNC	HGNC:26862
MGI	MGI:2685585
EntrezGene (human)	GeneID:124535 (SSTAR profile)
EntrezGene (mouse)	GeneID:327992 (SSTAR profile)
UniProt ID (human)	HSF5_HUMAN
UniProt ID (mouse)	HSF5_MOUSE
UniProt AC (human)	Q4G112 (TFClass)
UniProt AC (mouse)	Q5ND04 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	HSF5.H12CORE.0.M.C.pcm
PWM	HSF5.H12CORE.0.M.C.pwm
PFM	HSF5.H12CORE.0.M.C.pfm
Alignment	HSF5.H12CORE.0.M.C.words.tsv
Threshold to P-value map	HSF5.H12CORE.0.M.C.thr
Motif in other formats
JASPAR format	HSF5.H12CORE.0.M.C_jaspar_format.txt
MEME format	HSF5.H12CORE.0.M.C_meme_format.meme
Transfac format	HSF5.H12CORE.0.M.C_transfac_format.txt
Homer format	HSF5.H12CORE.0.M.C_homer_format_0.001.txt HSF5.H12CORE.0.M.C_homer_format_0.0005.txt HSF5.H12CORE.0.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1565.25	2426.25	1985.25	2140.25
02	805.25	3260.25	2218.25	1833.25
03	5746.0	700.0	679.0	992.0
04	6872.0	112.0	1112.0	21.0
05	47.0	7981.0	65.0	24.0
06	6997.0	0.0	1120.0	0.0
07	0.0	0.0	0.0	8117.0
08	0.0	0.0	0.0	8117.0
09	0.0	8117.0	0.0	0.0
10	0.0	4651.0	2.0	3464.0
11	5078.0	43.0	2939.0	57.0
12	2148.75	1685.75	1459.75	2822.75

PFM

	A	C	G	T
01	0.193	0.299	0.245	0.264
02	0.099	0.402	0.273	0.226
03	0.708	0.086	0.084	0.122
04	0.847	0.014	0.137	0.003
05	0.006	0.983	0.008	0.003
06	0.862	0.0	0.138	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	0.0	1.0
09	0.0	1.0	0.0	0.0
10	0.0	0.573	0.0	0.427
11	0.626	0.005	0.362	0.007
12	0.265	0.208	0.18	0.348

PWM

	A	C	G	T
01	-0.259	0.178	-0.022	0.053
02	-0.923	0.474	0.089	-0.101
03	1.04	-1.062	-1.093	-0.715
04	1.219	-2.878	-0.601	-4.47
05	-3.72	1.369	-3.408	-4.349
06	1.237	-6.805	-0.593	-6.805
07	-6.805	-6.805	-6.805	1.385
08	-6.805	-6.805	-6.805	1.385
09	-6.805	1.385	-6.805	-6.805
10	-6.805	0.829	-6.17	0.534
11	0.917	-3.804	0.37	-3.535
12	0.057	-0.185	-0.329	0.33

Standard thresholds

P-value	Threshold
0.001	1.997625
0.0005	3.57926
0.0001	7.16984