HSF4.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF4.H12RSNP.0.SM.B
Gene (human)	HSF4 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Hsf4
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	20
Consensus	nvKRGAAYRTTCTAGAAbvh
GC content	41.78%
Information content (bits; total / per base)	20.211 / 1.011
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	963

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.999	0.999	0.997	0.996	0.98	0.977
Overall, 4 experiments	best	1.0	1.0	1.0	1.0	0.996	0.995
Methyl HT-SELEX, 1 experiments	median	0.999	0.998	0.995	0.994	0.967	0.962
Methyl HT-SELEX, 1 experiments	best	0.999	0.998	0.995	0.994	0.967	0.962
Non-Methyl HT-SELEX, 3 experiments	median	1.0	0.999	0.999	0.998	0.992	0.992
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	1.0	0.996	0.995

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.929	0.861	0.94	0.65
batch 2	0.838	0.706	0.867	0.712

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.4
HGNC	HGNC:5227
MGI	MGI:1347058
EntrezGene (human)	GeneID:3299 (SSTAR profile)
EntrezGene (mouse)	GeneID:26386 (SSTAR profile)
UniProt ID (human)	HSF4_HUMAN
UniProt ID (mouse)	HSF4_MOUSE
UniProt AC (human)	Q9ULV5 (TFClass)
UniProt AC (mouse)	Q9R0L1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	HSF4.H12RSNP.0.SM.B.pcm
PWM	HSF4.H12RSNP.0.SM.B.pwm
PFM	HSF4.H12RSNP.0.SM.B.pfm
Alignment	HSF4.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	HSF4.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	HSF4.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	HSF4.H12RSNP.0.SM.B_meme_format.meme
Transfac format	HSF4.H12RSNP.0.SM.B_transfac_format.txt
Homer format	HSF4.H12RSNP.0.SM.B_homer_format_0.001.txt HSF4.H12RSNP.0.SM.B_homer_format_0.0005.txt HSF4.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	158.75	203.75	235.75	364.75
02	129.0	555.0	187.0	92.0
03	57.0	158.0	174.0	574.0
04	512.0	161.0	279.0	11.0
05	3.0	7.0	950.0	3.0
06	860.0	48.0	14.0	41.0
07	913.0	9.0	24.0	17.0
08	34.0	469.0	106.0	354.0
09	362.0	82.0	484.0	35.0
10	25.0	4.0	1.0	933.0
11	11.0	1.0	12.0	939.0
12	2.0	961.0	0.0	0.0
13	0.0	101.0	66.0	796.0
14	813.0	36.0	114.0	0.0
15	0.0	1.0	961.0	1.0
16	879.0	47.0	16.0	21.0
17	851.0	22.0	30.0	60.0
18	94.0	369.0	213.0	287.0
19	237.25	194.25	377.25	154.25
20	186.0	215.0	159.0	403.0

PFM

	A	C	G	T
01	0.165	0.212	0.245	0.379
02	0.134	0.576	0.194	0.096
03	0.059	0.164	0.181	0.596
04	0.532	0.167	0.29	0.011
05	0.003	0.007	0.987	0.003
06	0.893	0.05	0.015	0.043
07	0.948	0.009	0.025	0.018
08	0.035	0.487	0.11	0.368
09	0.376	0.085	0.503	0.036
10	0.026	0.004	0.001	0.969
11	0.011	0.001	0.012	0.975
12	0.002	0.998	0.0	0.0
13	0.0	0.105	0.069	0.827
14	0.844	0.037	0.118	0.0
15	0.0	0.001	0.998	0.001
16	0.913	0.049	0.017	0.022
17	0.884	0.023	0.031	0.062
18	0.098	0.383	0.221	0.298
19	0.246	0.202	0.392	0.16
20	0.193	0.223	0.165	0.418

PWM

	A	C	G	T
01	-0.413	-0.166	-0.021	0.413
02	-0.618	0.831	-0.251	-0.951
03	-1.418	-0.417	-0.322	0.865
04	0.751	-0.399	0.146	-2.948
05	-3.94	-3.326	1.367	-3.94
06	1.268	-1.585	-2.736	-1.736
07	1.328	-3.119	-2.244	-2.561
08	-1.915	0.663	-0.811	0.383
09	0.406	-1.063	0.695	-1.888
10	-2.206	-3.747	-4.491	1.349
11	-2.948	-4.491	-2.872	1.356
12	-4.178	1.379	-4.95	-4.95
13	-4.95	-0.859	-1.276	1.191
14	1.212	-1.861	-0.74	-4.95
15	-4.95	-4.491	1.379	-4.491
16	1.29	-1.605	-2.616	-2.368
17	1.258	-2.325	-2.034	-1.368
18	-0.929	0.425	-0.122	0.175
19	-0.015	-0.213	0.447	-0.441
20	-0.256	-0.112	-0.411	0.512

Standard thresholds

P-value	Threshold
0.001	-0.14964
0.0005	1.35161
0.0001	4.51776