HSF4.H12INVITRO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF4.H12INVITRO.0.SM.B
Gene (human)	HSF4 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Hsf4
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	15
Consensus	vGAAbvTTCYRGMWn
GC content	42.15%
Information content (bits; total / per base)	14.799 / 0.987
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9989

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.999	0.999	0.996	0.995	0.979	0.976
Overall, 4 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Methyl HT-SELEX, 1 experiments	median	0.998	0.998	0.994	0.992	0.962	0.957
Methyl HT-SELEX, 1 experiments	best	0.998	0.998	0.994	0.992	0.962	0.957
Non-Methyl HT-SELEX, 3 experiments	median	1.0	0.999	0.999	0.998	0.996	0.995
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.902	0.811	0.918	0.632
batch 2	0.794	0.683	0.858	0.654

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.4
HGNC	HGNC:5227
MGI	MGI:1347058
EntrezGene (human)	GeneID:3299 (SSTAR profile)
EntrezGene (mouse)	GeneID:26386 (SSTAR profile)
UniProt ID (human)	HSF4_HUMAN
UniProt ID (mouse)	HSF4_MOUSE
UniProt AC (human)	Q9ULV5 (TFClass)
UniProt AC (mouse)	Q9R0L1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	HSF4.H12INVITRO.0.SM.B.pcm
PWM	HSF4.H12INVITRO.0.SM.B.pwm
PFM	HSF4.H12INVITRO.0.SM.B.pfm
Alignment	HSF4.H12INVITRO.0.SM.B.words.tsv
Threshold to P-value map	HSF4.H12INVITRO.0.SM.B.thr
Motif in other formats
JASPAR format	HSF4.H12INVITRO.0.SM.B_jaspar_format.txt
MEME format	HSF4.H12INVITRO.0.SM.B_meme_format.meme
Transfac format	HSF4.H12INVITRO.0.SM.B_transfac_format.txt
Homer format	HSF4.H12INVITRO.0.SM.B_homer_format_0.001.txt HSF4.H12INVITRO.0.SM.B_homer_format_0.0005.txt HSF4.H12INVITRO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	4118.25	2438.25	2944.25	488.25
02	320.25	391.25	8974.25	303.25
03	9014.0	370.0	163.0	442.0
04	8913.0	233.0	304.0	539.0
05	814.0	4448.0	1874.0	2853.0
06	3381.0	1655.0	4231.0	722.0
07	579.0	297.0	130.0	8983.0
08	469.0	118.0	574.0	8828.0
09	3.0	9966.0	19.0	1.0
10	7.0	1644.0	972.0	7366.0
11	7418.0	992.0	1571.0	8.0
12	13.0	73.0	9889.0	14.0
13	7695.0	952.0	501.0	841.0
14	7002.5	831.5	845.5	1309.5
15	1758.0	3206.0	2544.0	2481.0

PFM

	A	C	G	T
01	0.412	0.244	0.295	0.049
02	0.032	0.039	0.898	0.03
03	0.902	0.037	0.016	0.044
04	0.892	0.023	0.03	0.054
05	0.081	0.445	0.188	0.286
06	0.338	0.166	0.424	0.072
07	0.058	0.03	0.013	0.899
08	0.047	0.012	0.057	0.884
09	0.0	0.998	0.002	0.0
10	0.001	0.165	0.097	0.737
11	0.743	0.099	0.157	0.001
12	0.001	0.007	0.99	0.001
13	0.77	0.095	0.05	0.084
14	0.701	0.083	0.085	0.131
15	0.176	0.321	0.255	0.248

PWM

	A	C	G	T
01	0.5	-0.024	0.165	-1.628
02	-2.048	-1.849	1.279	-2.102
03	1.283	-1.904	-2.716	-1.727
04	1.272	-2.363	-2.099	-1.53
05	-1.119	0.577	-0.287	0.133
06	0.303	-0.411	0.527	-1.239
07	-1.459	-2.122	-2.939	1.279
08	-1.668	-3.034	-1.467	1.262
09	-6.156	1.383	-4.765	-6.629
10	-5.594	-0.418	-0.942	1.081
11	1.088	-0.922	-0.463	-5.491
12	-5.096	-3.502	1.376	-5.033
13	1.125	-0.963	-1.603	-1.087
14	1.03	-1.098	-1.081	-0.645
15	-0.351	0.25	0.019	-0.007

Standard thresholds

P-value	Threshold
0.001	2.97001
0.0005	4.15956
0.0001	6.60016