HSF4.H12CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF4.H12CORE.0.SM.B
Gene (human)	HSF4 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Hsf4
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	19
Consensus	nvbRGAAbvTTCTAGAWbn
GC content	43.3%
Information content (bits; total / per base)	17.859 / 0.94
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2317

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.999	0.999	0.997	0.996	0.983	0.98
Overall, 4 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Methyl HT-SELEX, 1 experiments	median	0.999	0.998	0.996	0.994	0.969	0.965
Methyl HT-SELEX, 1 experiments	best	0.999	0.998	0.996	0.994	0.969	0.965
Non-Methyl HT-SELEX, 3 experiments	median	1.0	0.999	0.999	0.999	0.997	0.996
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.935	0.866	0.941	0.659
batch 2	0.818	0.662	0.849	0.66

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.4
HGNC	HGNC:5227
MGI	MGI:1347058
EntrezGene (human)	GeneID:3299 (SSTAR profile)
EntrezGene (mouse)	GeneID:26386 (SSTAR profile)
UniProt ID (human)	HSF4_HUMAN
UniProt ID (mouse)	HSF4_MOUSE
UniProt AC (human)	Q9ULV5 (TFClass)
UniProt AC (mouse)	Q9R0L1 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	HSF4.H12CORE.0.SM.B.pcm
PWM	HSF4.H12CORE.0.SM.B.pwm
PFM	HSF4.H12CORE.0.SM.B.pfm
Alignment	HSF4.H12CORE.0.SM.B.words.tsv
Threshold to P-value map	HSF4.H12CORE.0.SM.B.thr
Motif in other formats
JASPAR format	HSF4.H12CORE.0.SM.B_jaspar_format.txt
MEME format	HSF4.H12CORE.0.SM.B_meme_format.meme
Transfac format	HSF4.H12CORE.0.SM.B_transfac_format.txt
Homer format	HSF4.H12CORE.0.SM.B_homer_format_0.001.txt HSF4.H12CORE.0.SM.B_homer_format_0.0005.txt HSF4.H12CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	429.25	558.25	618.25	711.25
02	416.75	1202.75	473.75	223.75
03	179.0	394.0	416.0	1328.0
04	1105.0	463.0	716.0	33.0
05	17.0	24.0	2254.0	22.0
06	2098.0	100.0	32.0	87.0
07	2123.0	32.0	66.0	96.0
08	144.0	1056.0	334.0	783.0
09	768.0	322.0	1118.0	109.0
10	81.0	48.0	26.0	2162.0
11	69.0	5.0	84.0	2159.0
12	4.0	2313.0	0.0	0.0
13	3.0	323.0	141.0	1850.0
14	1825.0	167.0	324.0	1.0
15	3.0	9.0	2305.0	0.0
16	1983.0	136.0	71.0	127.0
17	1842.0	115.0	124.0	236.0
18	292.25	809.25	546.25	669.25
19	597.5	521.5	812.5	385.5

PFM

	A	C	G	T
01	0.185	0.241	0.267	0.307
02	0.18	0.519	0.204	0.097
03	0.077	0.17	0.18	0.573
04	0.477	0.2	0.309	0.014
05	0.007	0.01	0.973	0.009
06	0.905	0.043	0.014	0.038
07	0.916	0.014	0.028	0.041
08	0.062	0.456	0.144	0.338
09	0.331	0.139	0.483	0.047
10	0.035	0.021	0.011	0.933
11	0.03	0.002	0.036	0.932
12	0.002	0.998	0.0	0.0
13	0.001	0.139	0.061	0.798
14	0.788	0.072	0.14	0.0
15	0.001	0.004	0.995	0.0
16	0.856	0.059	0.031	0.055
17	0.795	0.05	0.054	0.102
18	0.126	0.349	0.236	0.289
19	0.258	0.225	0.351	0.166

PWM

	A	C	G	T
01	-0.299	-0.037	0.065	0.205
02	-0.328	0.729	-0.2	-0.946
03	-1.167	-0.384	-0.33	0.828
04	0.644	-0.223	0.211	-2.812
05	-3.424	-3.109	1.356	-3.19
06	1.285	-1.741	-2.841	-1.877
07	1.296	-2.841	-2.146	-1.781
08	-1.382	0.599	-0.548	0.301
09	0.281	-0.585	0.656	-1.656
10	-1.947	-2.454	-3.035	1.315
11	-2.103	-4.428	-1.911	1.313
12	-4.584	1.382	-5.704	-5.704
13	-4.768	-0.581	-1.403	1.159
14	1.145	-1.236	-0.578	-5.288
15	-4.768	-3.973	1.379	-5.704
16	1.228	-1.438	-2.075	-1.506
17	1.155	-1.603	-1.529	-0.893
18	-0.681	0.333	-0.058	0.144
19	0.031	-0.105	0.337	-0.406

Standard thresholds

P-value	Threshold
0.001	1.32996
0.0005	2.70336
0.0001	5.56886