HSF2.H12RSNP.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF2.H12RSNP.0.PSM.A
Gene (human)	HSF2 (GeneCards)
Gene synonyms (human)	HSTF2
Gene (mouse)	Hsf2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	18
Consensus	nbvGAAYRTTCTAGAAnn
GC content	39.37%
Information content (bits; total / per base)	19.997 / 1.111
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	955

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.919	0.955	0.883	0.914	0.915	0.957	5.159	5.676	106.137	226.62

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.999	0.999	0.996	0.995	0.945	0.944
Overall, 7 experiments	best	1.0	1.0	1.0	0.999	0.992	0.991
Methyl HT-SELEX, 3 experiments	median	1.0	0.999	0.996	0.995	0.949	0.946
Methyl HT-SELEX, 3 experiments	best	1.0	1.0	0.999	0.999	0.992	0.991
Non-Methyl HT-SELEX, 4 experiments	median	0.999	0.999	0.975	0.975	0.843	0.865
Non-Methyl HT-SELEX, 4 experiments	best	1.0	1.0	1.0	0.999	0.992	0.991

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.937	0.773	0.938	0.651
batch 2	0.844	0.676	0.827	0.679

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.2
HGNC	HGNC:5225
MGI	MGI:96239
EntrezGene (human)	GeneID:3298 (SSTAR profile)
EntrezGene (mouse)	GeneID:15500 (SSTAR profile)
UniProt ID (human)	HSF2_HUMAN
UniProt ID (mouse)	HSF2_MOUSE
UniProt AC (human)	Q03933 (TFClass)
UniProt AC (mouse)	P38533 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	3

PCM	HSF2.H12RSNP.0.PSM.A.pcm
PWM	HSF2.H12RSNP.0.PSM.A.pwm
PFM	HSF2.H12RSNP.0.PSM.A.pfm
Alignment	HSF2.H12RSNP.0.PSM.A.words.tsv
Threshold to P-value map	HSF2.H12RSNP.0.PSM.A.thr
Motif in other formats
JASPAR format	HSF2.H12RSNP.0.PSM.A_jaspar_format.txt
MEME format	HSF2.H12RSNP.0.PSM.A_meme_format.meme
Transfac format	HSF2.H12RSNP.0.PSM.A_transfac_format.txt
Homer format	HSF2.H12RSNP.0.PSM.A_homer_format_0.001.txt HSF2.H12RSNP.0.PSM.A_homer_format_0.0005.txt HSF2.H12RSNP.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	265.5	274.5	235.5	179.5
02	116.0	160.0	139.0	540.0
03	426.0	237.0	273.0	19.0
04	8.0	6.0	935.0	6.0
05	930.0	11.0	2.0	12.0
06	924.0	8.0	9.0	14.0
07	27.0	441.0	100.0	387.0
08	356.0	71.0	501.0	27.0
09	15.0	4.0	2.0	934.0
10	8.0	1.0	14.0	932.0
11	0.0	955.0	0.0	0.0
12	0.0	80.0	34.0	841.0
13	815.0	32.0	108.0	0.0
14	1.0	3.0	948.0	3.0
15	881.0	27.0	12.0	35.0
16	788.0	33.0	43.0	91.0
17	146.5	346.5	215.5	246.5
18	298.5	185.5	320.5	150.5

PFM

	A	C	G	T
01	0.278	0.287	0.247	0.188
02	0.121	0.168	0.146	0.565
03	0.446	0.248	0.286	0.02
04	0.008	0.006	0.979	0.006
05	0.974	0.012	0.002	0.013
06	0.968	0.008	0.009	0.015
07	0.028	0.462	0.105	0.405
08	0.373	0.074	0.525	0.028
09	0.016	0.004	0.002	0.978
10	0.008	0.001	0.015	0.976
11	0.0	1.0	0.0	0.0
12	0.0	0.084	0.036	0.881
13	0.853	0.034	0.113	0.0
14	0.001	0.003	0.993	0.003
15	0.923	0.028	0.013	0.037
16	0.825	0.035	0.045	0.095
17	0.153	0.363	0.226	0.258
18	0.313	0.194	0.336	0.158

PWM

	A	C	G	T
01	0.105	0.139	-0.014	-0.283
02	-0.714	-0.397	-0.536	0.812
03	0.576	-0.007	0.133	-2.452
04	-3.209	-3.439	1.36	-3.439
05	1.354	-2.94	-4.17	-2.864
06	1.348	-3.209	-3.111	-2.728
07	-2.125	0.61	-0.86	0.48
08	0.397	-1.196	0.737	-2.125
09	-2.666	-3.739	-4.17	1.359
10	-3.209	-4.484	-2.728	1.357
11	-4.943	1.381	-4.943	-4.943
12	-4.943	-1.079	-1.907	1.254
13	1.223	-1.965	-0.785	-4.943
14	-4.484	-3.932	1.374	-3.932
15	1.3	-2.125	-2.864	-1.879
16	1.189	-1.935	-1.682	-0.953
17	-0.484	0.37	-0.102	0.032
18	0.222	-0.25	0.293	-0.457

Standard thresholds

P-value	Threshold
0.001	-0.31329
0.0005	1.20891
0.0001	4.42576