HSF2.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF2.H12INVIVO.0.PSM.A
Gene (human)	HSF2 (GeneCards)
Gene synonyms (human)	HSTF2
Gene (mouse)	Hsf2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	RGAAnnYTCYRGAR
GC content	41.32%
Information content (bits; total / per base)	14.864 / 1.062
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	656

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.923	0.963	0.887	0.92	0.918	0.969	5.317	5.902	109.585	236.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	0.999	0.999	0.993	0.991	0.934	0.932
Overall, 7 experiments	best	1.0	1.0	1.0	0.999	0.998	0.997
Methyl HT-SELEX, 3 experiments	median	0.999	0.999	0.997	0.996	0.944	0.942
Methyl HT-SELEX, 3 experiments	best	1.0	1.0	0.999	0.999	0.997	0.997
Non-Methyl HT-SELEX, 4 experiments	median	0.998	0.998	0.969	0.968	0.833	0.855
Non-Methyl HT-SELEX, 4 experiments	best	1.0	0.999	1.0	0.999	0.998	0.997

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.889	0.635	0.896	0.638
batch 2	0.799	0.579	0.784	0.646

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.2
HGNC	HGNC:5225
MGI	MGI:96239
EntrezGene (human)	GeneID:3298 (SSTAR profile)
EntrezGene (mouse)	GeneID:15500 (SSTAR profile)
UniProt ID (human)	HSF2_HUMAN
UniProt ID (mouse)	HSF2_MOUSE
UniProt AC (human)	Q03933 (TFClass)
UniProt AC (mouse)	P38533 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	3

PCM	HSF2.H12INVIVO.0.PSM.A.pcm
PWM	HSF2.H12INVIVO.0.PSM.A.pwm
PFM	HSF2.H12INVIVO.0.PSM.A.pfm
Alignment	HSF2.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	HSF2.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	HSF2.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	HSF2.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	HSF2.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	HSF2.H12INVIVO.0.PSM.A_homer_format_0.001.txt HSF2.H12INVIVO.0.PSM.A_homer_format_0.0005.txt HSF2.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	380.0	26.0	227.0	23.0
02	3.0	6.0	642.0	5.0
03	609.0	18.0	12.0	17.0
04	575.0	19.0	31.0	31.0
05	169.0	173.0	189.0	125.0
06	159.0	160.0	203.0	134.0
07	55.0	58.0	24.0	519.0
08	33.0	18.0	59.0	546.0
09	3.0	647.0	5.0	1.0
10	8.0	217.0	27.0	404.0
11	443.0	19.0	190.0	4.0
12	4.0	2.0	641.0	9.0
13	572.0	29.0	35.0	20.0
14	509.0	55.0	63.0	29.0

PFM

	A	C	G	T
01	0.579	0.04	0.346	0.035
02	0.005	0.009	0.979	0.008
03	0.928	0.027	0.018	0.026
04	0.877	0.029	0.047	0.047
05	0.258	0.264	0.288	0.191
06	0.242	0.244	0.309	0.204
07	0.084	0.088	0.037	0.791
08	0.05	0.027	0.09	0.832
09	0.005	0.986	0.008	0.002
10	0.012	0.331	0.041	0.616
11	0.675	0.029	0.29	0.006
12	0.006	0.003	0.977	0.014
13	0.872	0.044	0.053	0.03
14	0.776	0.084	0.096	0.044

PWM

	A	C	G	T
01	0.835	-1.791	0.322	-1.906
02	-3.579	-3.079	1.357	-3.219
03	1.305	-2.133	-2.498	-2.185
04	1.247	-2.083	-1.625	-1.625
05	0.03	0.053	0.141	-0.269
06	-0.031	-0.024	0.211	-0.2
07	-1.073	-1.022	-1.866	1.145
08	-1.565	-2.133	-1.005	1.196
09	-3.579	1.365	-3.219	-4.146
10	-2.846	0.278	-1.756	0.896
11	0.988	-2.083	0.146	-3.383
12	-3.383	-3.823	1.356	-2.747
13	1.242	-1.688	-1.509	-2.036
14	1.126	-1.073	-0.941	-1.688

Standard thresholds

P-value	Threshold
0.001	3.12231
0.0005	4.27571
0.0001	6.61147