HSF2.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF2.H12INVITRO.0.PSM.A
Gene (human)	HSF2 (GeneCards)
Gene synonyms (human)	HSTF2
Gene (mouse)	Hsf2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	17
Consensus	nbvGAAbvTTCTAGAWn
GC content	40.64%
Information content (bits; total / per base)	17.561 / 1.033
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9563

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.922	0.962	0.884	0.922	0.918	0.963	5.308	5.835	113.77	235.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 7 experiments	median	1.0	0.999	0.996	0.996	0.945	0.943
Overall, 7 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Methyl HT-SELEX, 3 experiments	median	1.0	0.999	0.996	0.996	0.945	0.943
Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	0.999	0.997	0.996
Non-Methyl HT-SELEX, 4 experiments	median	0.999	0.999	0.975	0.975	0.845	0.866
Non-Methyl HT-SELEX, 4 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.928	0.75	0.918	0.635
batch 2	0.899	0.72	0.799	0.637

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.2
HGNC	HGNC:5225
MGI	MGI:96239
EntrezGene (human)	GeneID:3298 (SSTAR profile)
EntrezGene (mouse)	GeneID:15500 (SSTAR profile)
UniProt ID (human)	HSF2_HUMAN
UniProt ID (mouse)	HSF2_MOUSE
UniProt AC (human)	Q03933 (TFClass)
UniProt AC (mouse)	P38533 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	3

PCM	HSF2.H12INVITRO.0.PSM.A.pcm
PWM	HSF2.H12INVITRO.0.PSM.A.pwm
PFM	HSF2.H12INVITRO.0.PSM.A.pfm
Alignment	HSF2.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	HSF2.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	HSF2.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	HSF2.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	HSF2.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	HSF2.H12INVITRO.0.PSM.A_homer_format_0.001.txt HSF2.H12INVITRO.0.PSM.A_homer_format_0.0005.txt HSF2.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2840.25	2148.25	2681.25	1893.25
02	1297.25	1969.25	1492.25	4804.25
03	3988.0	2381.0	2975.0	219.0
04	89.0	94.0	9321.0	59.0
05	9160.0	113.0	80.0	210.0
06	8975.0	100.0	129.0	359.0
07	617.0	3955.0	1440.0	3551.0
08	3030.0	1168.0	4804.0	561.0
09	349.0	122.0	84.0	9008.0
10	189.0	11.0	278.0	9085.0
11	2.0	9554.0	7.0	0.0
12	6.0	1245.0	666.0	7646.0
13	7466.0	665.0	1423.0	9.0
14	12.0	25.0	9487.0	39.0
15	8269.0	494.0	210.0	590.0
16	7019.75	702.75	753.75	1086.75
17	1820.75	2933.75	2549.75	2258.75

PFM

	A	C	G	T
01	0.297	0.225	0.28	0.198
02	0.136	0.206	0.156	0.502
03	0.417	0.249	0.311	0.023
04	0.009	0.01	0.975	0.006
05	0.958	0.012	0.008	0.022
06	0.939	0.01	0.013	0.038
07	0.065	0.414	0.151	0.371
08	0.317	0.122	0.502	0.059
09	0.036	0.013	0.009	0.942
10	0.02	0.001	0.029	0.95
11	0.0	0.999	0.001	0.0
12	0.001	0.13	0.07	0.8
13	0.781	0.07	0.149	0.001
14	0.001	0.003	0.992	0.004
15	0.865	0.052	0.022	0.062
16	0.734	0.073	0.079	0.114
17	0.19	0.307	0.267	0.236

PWM

	A	C	G	T
01	0.172	-0.107	0.115	-0.233
02	-0.611	-0.194	-0.471	0.697
03	0.511	-0.004	0.218	-2.381
04	-3.266	-3.213	1.36	-3.665
05	1.343	-3.033	-3.37	-2.422
06	1.322	-3.152	-2.903	-1.891
07	-1.352	0.503	-0.506	0.395
08	0.237	-0.715	0.697	-1.447
09	-1.919	-2.958	-3.323	1.326
10	-2.527	-5.193	-2.144	1.334
11	-6.324	1.385	-5.551	-6.951
12	-5.665	-0.652	-1.276	1.162
13	1.138	-1.277	-0.518	-5.356
14	-5.121	-4.474	1.378	-4.06
15	1.24	-1.573	-2.422	-1.396
16	1.076	-1.222	-1.152	-0.787
17	-0.272	0.204	0.064	-0.057

Standard thresholds

P-value	Threshold
0.001	1.03671
0.0005	2.47576
0.0001	5.47341