HSF1.H12RSNP.2.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H12RSNP.2.P.B
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	16
Consensus	KYSbKGGTTCRAdbCC
GC content	59.84%
Information content (bits; total / per base)	16.262 / 1.016
Data sources	ChIP-Seq
Aligned words	141

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.467	0.588	0.301	0.51	0.435	0.61	0.874	3.473	0	57.252
Mouse	11 (62)	0.51	0.85	0.322	0.653	0.452	0.92	0.937	8.311	0.0	63.051

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.527	0.516	0.515	0.511	0.508	0.507
Overall, 8 experiments	best	0.805	0.728	0.76	0.695	0.694	0.651
Methyl HT-SELEX, 2 experiments	median	0.463	0.475	0.479	0.484	0.486	0.489
Methyl HT-SELEX, 2 experiments	best	0.468	0.477	0.482	0.486	0.488	0.49
Non-Methyl HT-SELEX, 6 experiments	median	0.573	0.542	0.553	0.533	0.533	0.524
Non-Methyl HT-SELEX, 6 experiments	best	0.805	0.728	0.76	0.695	0.694	0.651

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.479	0.017	0.186	0.146
batch 2	0.504	0.078	0.051	0.031

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	HSF1.H12RSNP.2.P.B.pcm
PWM	HSF1.H12RSNP.2.P.B.pwm
PFM	HSF1.H12RSNP.2.P.B.pfm
Alignment	HSF1.H12RSNP.2.P.B.words.tsv
Threshold to P-value map	HSF1.H12RSNP.2.P.B.thr
Motif in other formats
JASPAR format	HSF1.H12RSNP.2.P.B_jaspar_format.txt
MEME format	HSF1.H12RSNP.2.P.B_meme_format.meme
Transfac format	HSF1.H12RSNP.2.P.B_transfac_format.txt
Homer format	HSF1.H12RSNP.2.P.B_homer_format_0.001.txt HSF1.H12RSNP.2.P.B_homer_format_0.0005.txt HSF1.H12RSNP.2.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	24.0	6.0	32.0	79.0
02	7.0	104.0	1.0	29.0
03	6.0	65.0	64.0	6.0
04	12.0	78.0	20.0	31.0
05	18.0	11.0	89.0	23.0
06	17.0	0.0	121.0	3.0
07	0.0	2.0	134.0	5.0
08	7.0	7.0	4.0	123.0
09	0.0	2.0	2.0	137.0
10	3.0	134.0	2.0	2.0
11	22.0	9.0	102.0	8.0
12	135.0	2.0	3.0	1.0
13	48.0	7.0	44.0	42.0
14	10.0	29.0	21.0	81.0
15	10.0	129.0	2.0	0.0
16	6.0	122.0	2.0	11.0

PFM

	A	C	G	T
01	0.17	0.043	0.227	0.56
02	0.05	0.738	0.007	0.206
03	0.043	0.461	0.454	0.043
04	0.085	0.553	0.142	0.22
05	0.128	0.078	0.631	0.163
06	0.121	0.0	0.858	0.021
07	0.0	0.014	0.95	0.035
08	0.05	0.05	0.028	0.872
09	0.0	0.014	0.014	0.972
10	0.021	0.95	0.014	0.014
11	0.156	0.064	0.723	0.057
12	0.957	0.014	0.021	0.007
13	0.34	0.05	0.312	0.298
14	0.071	0.206	0.149	0.574
15	0.071	0.915	0.014	0.0
16	0.043	0.865	0.014	0.078

PWM

	A	C	G	T
01	-0.369	-1.618	-0.093	0.788
02	-1.488	1.059	-2.792	-0.188
03	-1.618	0.596	0.581	-1.618
04	-1.014	0.775	-0.541	-0.124
05	-0.64	-1.092	0.905	-0.409
06	-0.693	-3.384	1.209	-2.153
07	-3.384	-2.422	1.31	-1.766
08	-1.488	-1.488	-1.941	1.225
09	-3.384	-2.422	-2.422	1.332
10	-2.153	1.31	-2.422	-2.422
11	-0.451	-1.271	1.04	-1.374
12	1.317	-2.422	-2.153	-2.792
13	0.3	-1.488	0.215	0.17
14	-1.178	-0.188	-0.495	0.813
15	-1.178	1.272	-2.422	-3.384
16	-1.618	1.217	-2.422	-1.092

Standard thresholds

P-value	Threshold
0.001	3.15886
0.0005	4.24661
0.0001	6.54406