HSF1.H12RSNP.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H12RSNP.1.P.B
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	9
Consensus	bTTCYAGAR
GC content	38.78%
Information content (bits; total / per base)	11.902 / 1.322
Data sources	ChIP-Seq
Aligned words	206

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.847	0.947	0.764	0.903	0.81	0.907	2.769	3.454	111.721	505.602
Mouse	11 (62)	0.861	0.886	0.764	0.821	0.851	0.879	2.936	3.265	232.438	405.409

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.989	0.981	0.972	0.961	0.897	0.891
Overall, 8 experiments	best	0.998	0.996	0.996	0.994	0.988	0.984
Methyl HT-SELEX, 2 experiments	median	0.993	0.987	0.985	0.977	0.962	0.95
Methyl HT-SELEX, 2 experiments	best	0.994	0.989	0.987	0.981	0.97	0.96
Non-Methyl HT-SELEX, 6 experiments	median	0.982	0.974	0.954	0.939	0.839	0.837
Non-Methyl HT-SELEX, 6 experiments	best	0.998	0.996	0.996	0.994	0.988	0.984

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.874	0.34	0.787	0.473
batch 2	0.55	0.148	0.46	0.26

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	HSF1.H12RSNP.1.P.B.pcm
PWM	HSF1.H12RSNP.1.P.B.pwm
PFM	HSF1.H12RSNP.1.P.B.pfm
Alignment	HSF1.H12RSNP.1.P.B.words.tsv
Threshold to P-value map	HSF1.H12RSNP.1.P.B.thr
Motif in other formats
JASPAR format	HSF1.H12RSNP.1.P.B_jaspar_format.txt
MEME format	HSF1.H12RSNP.1.P.B_meme_format.meme
Transfac format	HSF1.H12RSNP.1.P.B_transfac_format.txt
Homer format	HSF1.H12RSNP.1.P.B_homer_format_0.001.txt HSF1.H12RSNP.1.P.B_homer_format_0.0005.txt HSF1.H12RSNP.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	18.0	62.0	45.0	81.0
02	0.0	5.0	1.0	200.0
03	2.0	0.0	0.0	204.0
04	0.0	206.0	0.0	0.0
05	4.0	113.0	5.0	84.0
06	190.0	9.0	7.0	0.0
07	1.0	1.0	203.0	1.0
08	170.0	21.0	4.0	11.0
09	153.0	15.0	22.0	16.0

PFM

	A	C	G	T
01	0.087	0.301	0.218	0.393
02	0.0	0.024	0.005	0.971
03	0.01	0.0	0.0	0.99
04	0.0	1.0	0.0	0.0
05	0.019	0.549	0.024	0.408
06	0.922	0.044	0.034	0.0
07	0.005	0.005	0.985	0.005
08	0.825	0.102	0.019	0.053
09	0.743	0.073	0.107	0.078

PWM

	A	C	G	T
01	-1.005	0.181	-0.131	0.444
02	-3.68	-2.122	-3.12	1.338
03	-2.764	-3.68	-3.68	1.358
04	-3.68	1.367	-3.68	-3.68
05	-2.293	0.772	-2.122	0.479
06	1.287	-1.632	-1.847	-3.68
07	-3.12	-3.12	1.353	-3.12
08	1.176	-0.861	-2.293	-1.455
09	1.072	-1.174	-0.817	-1.115

Standard thresholds

P-value	Threshold
0.001	4.4317
0.0005	5.164515
0.0001	7.4086