HSF1.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H12INVIVO.0.PSM.A
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	16
Consensus	vbRGAAnnTTCYRGAR
GC content	43.34%
Information content (bits; total / per base)	16.025 / 1.002
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	998

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.926	0.993	0.892	0.984	0.919	0.991	5.529	7.231	163.387	737.569
Mouse	11 (62)	0.937	0.986	0.919	0.967	0.941	0.987	6.029	7.117	350.748	640.77

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	1.0	0.999	0.998	0.997	0.948	0.951
Overall, 8 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Methyl HT-SELEX, 2 experiments	median	1.0	1.0	1.0	0.999	0.997	0.996
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Non-Methyl HT-SELEX, 6 experiments	median	0.999	0.999	0.995	0.994	0.902	0.91
Non-Methyl HT-SELEX, 6 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.952	0.616	0.941	0.652
batch 2	0.593	0.166	0.505	0.303

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	HSF1.H12INVIVO.0.PSM.A.pcm
PWM	HSF1.H12INVIVO.0.PSM.A.pwm
PFM	HSF1.H12INVIVO.0.PSM.A.pfm
Alignment	HSF1.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	HSF1.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	HSF1.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	HSF1.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	HSF1.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	HSF1.H12INVIVO.0.PSM.A_homer_format_0.001.txt HSF1.H12INVIVO.0.PSM.A_homer_format_0.0005.txt HSF1.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	235.0	440.0	203.0	120.0
02	140.0	272.0	198.0	388.0
03	548.0	40.0	378.0	32.0
04	6.0	1.0	989.0	2.0
05	945.0	21.0	18.0	14.0
06	903.0	16.0	46.0	33.0
07	258.0	267.0	283.0	190.0
08	180.0	254.0	372.0	192.0
09	88.0	68.0	26.0	816.0
10	37.0	31.0	87.0	843.0
11	1.0	992.0	2.0	3.0
12	11.0	322.0	43.0	622.0
13	650.0	24.0	319.0	5.0
14	0.0	2.0	991.0	5.0
15	909.0	33.0	30.0	26.0
16	783.0	55.0	97.0	63.0

PFM

	A	C	G	T
01	0.235	0.441	0.203	0.12
02	0.14	0.273	0.198	0.389
03	0.549	0.04	0.379	0.032
04	0.006	0.001	0.991	0.002
05	0.947	0.021	0.018	0.014
06	0.905	0.016	0.046	0.033
07	0.259	0.268	0.284	0.19
08	0.18	0.255	0.373	0.192
09	0.088	0.068	0.026	0.818
10	0.037	0.031	0.087	0.845
11	0.001	0.994	0.002	0.003
12	0.011	0.323	0.043	0.623
13	0.651	0.024	0.32	0.005
14	0.0	0.002	0.993	0.005
15	0.911	0.033	0.03	0.026
16	0.785	0.055	0.097	0.063

PWM

	A	C	G	T
01	-0.059	0.564	-0.205	-0.725
02	-0.572	0.086	-0.229	0.439
03	0.783	-1.795	0.413	-2.008
04	-3.482	-4.523	1.372	-4.211
05	1.327	-2.403	-2.544	-2.771
06	1.281	-2.651	-1.661	-1.979
07	0.033	0.067	0.125	-0.27
08	-0.324	0.018	0.397	-0.26
09	-1.03	-1.282	-2.204	1.18
10	-1.87	-2.038	-1.041	1.213
11	-4.523	1.375	-4.211	-3.973
12	-2.983	0.254	-1.726	0.909
13	0.953	-2.279	0.244	-3.62
14	-4.98	-4.211	1.374	-3.62
15	1.288	-1.979	-2.069	-2.204
16	1.139	-1.488	-0.934	-1.356

Standard thresholds

P-value	Threshold
0.001	2.35076
0.0005	3.63026
0.0001	6.23701