HSF1.H12INVITRO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H12INVITRO.1.P.B
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	9
Consensus	bTTCTRGAW
GC content	41.18%
Information content (bits; total / per base)	11.601 / 1.289
Data sources	ChIP-Seq
Aligned words	388

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.842	0.941	0.766	0.895	0.801	0.902	2.784	3.462	117.081	546.18
Mouse	11 (62)	0.867	0.896	0.772	0.825	0.855	0.891	3.003	3.42	238.524	423.432

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.992	0.987	0.974	0.965	0.893	0.89
Overall, 8 experiments	best	0.999	0.997	0.998	0.996	0.991	0.988
Methyl HT-SELEX, 2 experiments	median	0.995	0.991	0.986	0.98	0.957	0.946
Methyl HT-SELEX, 2 experiments	best	0.996	0.993	0.989	0.984	0.966	0.957
Non-Methyl HT-SELEX, 6 experiments	median	0.988	0.981	0.959	0.946	0.832	0.836
Non-Methyl HT-SELEX, 6 experiments	best	0.999	0.997	0.998	0.996	0.991	0.988

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.897	0.268	0.771	0.479
batch 2	0.573	0.127	0.419	0.235

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	HSF1.H12INVITRO.1.P.B.pcm
PWM	HSF1.H12INVITRO.1.P.B.pwm
PFM	HSF1.H12INVITRO.1.P.B.pfm
Alignment	HSF1.H12INVITRO.1.P.B.words.tsv
Threshold to P-value map	HSF1.H12INVITRO.1.P.B.thr
Motif in other formats
JASPAR format	HSF1.H12INVITRO.1.P.B_jaspar_format.txt
MEME format	HSF1.H12INVITRO.1.P.B_meme_format.meme
Transfac format	HSF1.H12INVITRO.1.P.B_transfac_format.txt
Homer format	HSF1.H12INVITRO.1.P.B_homer_format_0.001.txt HSF1.H12INVITRO.1.P.B_homer_format_0.0005.txt HSF1.H12INVITRO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	36.0	118.0	141.0	93.0
02	16.0	18.0	8.0	346.0
03	5.0	2.0	14.0	367.0
04	1.0	387.0	0.0	0.0
05	5.0	4.0	3.0	376.0
06	124.0	20.0	242.0	2.0
07	2.0	1.0	385.0	0.0
08	331.0	25.0	16.0	16.0
09	301.0	25.0	29.0	33.0

PFM

	A	C	G	T
01	0.093	0.304	0.363	0.24
02	0.041	0.046	0.021	0.892
03	0.013	0.005	0.036	0.946
04	0.003	0.997	0.0	0.0
05	0.013	0.01	0.008	0.969
06	0.32	0.052	0.624	0.005
07	0.005	0.003	0.992	0.0
08	0.853	0.064	0.041	0.041
09	0.776	0.064	0.075	0.085

PWM

	A	C	G	T
01	-0.966	0.193	0.369	-0.041
02	-1.728	-1.62	-2.34	1.261
03	-2.72	-3.34	-1.85	1.319
04	-3.678	1.372	-4.191	-4.191
05	-2.72	-2.887	-3.088	1.344
06	0.242	-1.522	0.905	-3.34
07	-3.34	-3.678	1.367	-4.191
08	1.217	-1.313	-1.728	-1.728
09	1.122	-1.313	-1.173	-1.049

Standard thresholds

P-value	Threshold
0.001	4.32695
0.0005	5.196985
0.0001	7.326495