HSF1.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H12INVITRO.0.PSM.A
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	16
Consensus	bvGAAYRTTCYRGAWn
GC content	40.92%
Information content (bits; total / per base)	18.237 / 1.14
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9752

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.916	0.989	0.881	0.978	0.905	0.989	5.008	6.551	152.102	700.252
Mouse	11 (62)	0.938	0.981	0.911	0.958	0.937	0.979	5.674	6.504	357.082	607.469

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	1.0	1.0	0.998	0.998	0.956	0.959
Overall, 8 experiments	best	1.0	1.0	1.0	1.0	1.0	0.999
Methyl HT-SELEX, 2 experiments	median	1.0	1.0	1.0	0.999	0.995	0.994
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	1.0	0.999	0.998
Non-Methyl HT-SELEX, 6 experiments	median	1.0	0.999	0.997	0.996	0.915	0.921
Non-Methyl HT-SELEX, 6 experiments	best	1.0	1.0	1.0	1.0	1.0	0.999

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.958	0.58	0.943	0.629
batch 2	0.562	0.168	0.539	0.296

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	HSF1.H12INVITRO.0.PSM.A.pcm
PWM	HSF1.H12INVITRO.0.PSM.A.pwm
PFM	HSF1.H12INVITRO.0.PSM.A.pfm
Alignment	HSF1.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	HSF1.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	HSF1.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	HSF1.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	HSF1.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	HSF1.H12INVITRO.0.PSM.A_homer_format_0.001.txt HSF1.H12INVITRO.0.PSM.A_homer_format_0.0005.txt HSF1.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1368.5	1991.5	2032.5	4359.5
02	3671.75	2206.75	3569.75	303.75
03	55.0	80.0	9575.0	42.0
04	9372.0	137.0	51.0	192.0
05	9400.0	42.0	69.0	241.0
06	433.0	4230.0	743.0	4346.0
07	3274.0	592.0	5648.0	238.0
08	132.0	32.0	32.0	9556.0
09	83.0	4.0	157.0	9508.0
10	2.0	9746.0	4.0	0.0
11	10.0	1326.0	1232.0	7184.0
12	6901.0	1128.0	1707.0	16.0
13	1.0	33.0	9700.0	18.0
14	8708.0	442.0	185.0	417.0
15	7051.0	777.0	770.0	1154.0
16	1844.75	3215.75	2393.75	2297.75

PFM

	A	C	G	T
01	0.14	0.204	0.208	0.447
02	0.377	0.226	0.366	0.031
03	0.006	0.008	0.982	0.004
04	0.961	0.014	0.005	0.02
05	0.964	0.004	0.007	0.025
06	0.044	0.434	0.076	0.446
07	0.336	0.061	0.579	0.024
08	0.014	0.003	0.003	0.98
09	0.009	0.0	0.016	0.975
10	0.0	0.999	0.0	0.0
11	0.001	0.136	0.126	0.737
12	0.708	0.116	0.175	0.002
13	0.0	0.003	0.995	0.002
14	0.893	0.045	0.019	0.043
15	0.723	0.08	0.079	0.118
16	0.189	0.33	0.245	0.236

PWM

	A	C	G	T
01	-0.577	-0.202	-0.182	0.581
02	0.409	-0.1	0.381	-2.076
03	-3.752	-3.39	1.367	-4.009
04	1.346	-2.863	-3.824	-2.53
05	1.349	-4.009	-3.533	-2.306
06	-1.724	0.551	-1.186	0.578
07	0.295	-1.412	0.84	-2.318
08	-2.9	-4.265	-4.265	1.365
09	-3.354	-5.96	-2.729	1.36
10	-6.342	1.385	-5.96	-6.969
11	-5.291	-0.608	-0.682	1.08
12	1.04	-0.77	-0.356	-4.893
13	-6.607	-4.236	1.38	-4.789
14	1.272	-1.703	-2.567	-1.761
15	1.061	-1.141	-1.151	-0.747
16	-0.279	0.277	-0.018	-0.059

Standard thresholds

P-value	Threshold
0.001	0.06786
0.0005	1.64091
0.0001	4.91426