HSF1.H12CORE.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HSF1.H12CORE.0.PSM.A
Gene (human)	HSF1 (GeneCards)
Gene synonyms (human)	HSTF1
Gene (mouse)	Hsf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	18
Consensus	nhRGAAbRTTCTAGAAnv
GC content	38.17%
Information content (bits; total / per base)	20.888 / 1.16
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	2367

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	37 (203)	0.917	0.992	0.884	0.983	0.91	0.991	5.258	6.818	156.092	708.119
Mouse	11 (62)	0.936	0.981	0.912	0.959	0.94	0.982	5.9	6.813	349.188	597.658

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	1.0	1.0	0.998	0.998	0.952	0.955
Overall, 8 experiments	best	1.0	1.0	1.0	1.0	1.0	1.0
Methyl HT-SELEX, 2 experiments	median	1.0	1.0	1.0	0.999	0.994	0.993
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	1.0	0.998	0.998
Non-Methyl HT-SELEX, 6 experiments	median	1.0	0.999	0.996	0.996	0.908	0.916
Non-Methyl HT-SELEX, 6 experiments	best	1.0	1.0	1.0	1.0	1.0	1.0

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.959	0.727	0.95	0.603
batch 2	0.591	0.204	0.556	0.308

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Heat shock factors {3.4} (TFClass)
TF family	HSF {3.4.1} (TFClass)
TF subfamily	{3.4.1.0} (TFClass)
TFClass ID	TFClass: 3.4.1.0.1
HGNC	HGNC:5224
MGI	MGI:96238
EntrezGene (human)	GeneID:3297 (SSTAR profile)
EntrezGene (mouse)	GeneID:15499 (SSTAR profile)
UniProt ID (human)	HSF1_HUMAN
UniProt ID (mouse)	HSF1_MOUSE
UniProt AC (human)	Q00613 (TFClass)
UniProt AC (mouse)	P38532 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	37 human, 11 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	HSF1.H12CORE.0.PSM.A.pcm
PWM	HSF1.H12CORE.0.PSM.A.pwm
PFM	HSF1.H12CORE.0.PSM.A.pfm
Alignment	HSF1.H12CORE.0.PSM.A.words.tsv
Threshold to P-value map	HSF1.H12CORE.0.PSM.A.thr
Motif in other formats
JASPAR format	HSF1.H12CORE.0.PSM.A_jaspar_format.txt
MEME format	HSF1.H12CORE.0.PSM.A_meme_format.meme
Transfac format	HSF1.H12CORE.0.PSM.A_transfac_format.txt
Homer format	HSF1.H12CORE.0.PSM.A_homer_format_0.001.txt HSF1.H12CORE.0.PSM.A_homer_format_0.0005.txt HSF1.H12CORE.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	828.25	581.25	553.25	404.25
02	388.25	600.25	331.25	1047.25
03	1223.0	433.0	682.0	29.0
04	9.0	8.0	2339.0	11.0
05	2336.0	11.0	11.0	9.0
06	2317.0	8.0	17.0	25.0
07	188.0	1046.0	229.0	904.0
08	892.0	169.0	1218.0	88.0
09	17.0	4.0	1.0	2345.0
10	2.0	1.0	9.0	2355.0
11	2.0	2365.0	0.0	0.0
12	1.0	224.0	236.0	1906.0
13	2032.0	137.0	198.0	0.0
14	1.0	1.0	2363.0	2.0
15	2318.0	24.0	10.0	15.0
16	2250.0	22.0	30.0	65.0
17	572.75	717.75	552.75	523.75
18	878.0	406.0	723.0	360.0

PFM

	A	C	G	T
01	0.35	0.246	0.234	0.171
02	0.164	0.254	0.14	0.442
03	0.517	0.183	0.288	0.012
04	0.004	0.003	0.988	0.005
05	0.987	0.005	0.005	0.004
06	0.979	0.003	0.007	0.011
07	0.079	0.442	0.097	0.382
08	0.377	0.071	0.515	0.037
09	0.007	0.002	0.0	0.991
10	0.001	0.0	0.004	0.995
11	0.001	0.999	0.0	0.0
12	0.0	0.095	0.1	0.805
13	0.858	0.058	0.084	0.0
14	0.0	0.0	0.998	0.001
15	0.979	0.01	0.004	0.006
16	0.951	0.009	0.013	0.027
17	0.242	0.303	0.234	0.221
18	0.371	0.172	0.305	0.152

PWM

	A	C	G	T
01	0.335	-0.018	-0.067	-0.38
02	-0.42	0.014	-0.578	0.569
03	0.724	-0.311	0.142	-2.954
04	-3.994	-4.09	1.372	-3.826
05	1.371	-3.826	-3.826	-3.994
06	1.363	-4.09	-3.445	-3.093
07	-1.14	0.568	-0.944	0.423
08	0.409	-1.245	0.72	-1.887
09	-3.445	-4.604	-5.307	1.375
10	-5.015	-5.307	-3.994	1.379
11	-5.015	1.383	-5.722	-5.722
12	-5.307	-0.966	-0.914	1.167
13	1.231	-1.452	-1.088	-5.722
14	-5.307	-5.307	1.382	-5.015
15	1.363	-3.13	-3.906	-3.557
16	1.333	-3.211	-2.922	-2.183
17	-0.033	0.192	-0.068	-0.122
18	0.393	-0.375	0.2	-0.495

Standard thresholds

P-value	Threshold
0.001	-2.43159
0.0005	-0.66824
0.0001	3.06226