HNF6.H12INVIVO.3.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF6.H12INVIVO.3.M.B
Gene (human)	ONECUT1 (GeneCards)
Gene synonyms (human)	HNF6, HNF6A
Gene (mouse)	Onecut1
Gene synonyms (mouse)	Hnf6, Hnf6a
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	B

Motif length	14
Consensus	nnTATTGATTRRYn
GC content	28.92%
Information content (bits; total / per base)	16.874 / 1.205
Data sources	Methyl-HT-SELEX
Aligned words	341

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	12 (54)	0.853	0.9	0.822	0.872	0.84	0.889	3.184	3.757	360.041	470.509

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.986	0.974	0.974	0.959	0.949	0.928
Overall, 10 experiments	best	0.998	0.996	0.998	0.995	0.996	0.994
Methyl HT-SELEX, 3 experiments	median	0.993	0.988	0.991	0.984	0.983	0.974
Methyl HT-SELEX, 3 experiments	best	0.998	0.996	0.998	0.995	0.996	0.994
Non-Methyl HT-SELEX, 7 experiments	median	0.979	0.966	0.966	0.946	0.94	0.916
Non-Methyl HT-SELEX, 7 experiments	best	0.99	0.983	0.98	0.97	0.97	0.954

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.1
HGNC	HGNC:8138
MGI	MGI:1196423
EntrezGene (human)	GeneID:3175 (SSTAR profile)
EntrezGene (mouse)	GeneID:15379 (SSTAR profile)
UniProt ID (human)	HNF6_HUMAN
UniProt ID (mouse)	HNF6_MOUSE
UniProt AC (human)	Q9UBC0 (TFClass)
UniProt AC (mouse)	O08755 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 12 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	HNF6.H12INVIVO.3.M.B.pcm
PWM	HNF6.H12INVIVO.3.M.B.pwm
PFM	HNF6.H12INVIVO.3.M.B.pfm
Alignment	HNF6.H12INVIVO.3.M.B.words.tsv
Threshold to P-value map	HNF6.H12INVIVO.3.M.B.thr
Motif in other formats
JASPAR format	HNF6.H12INVIVO.3.M.B_jaspar_format.txt
MEME format	HNF6.H12INVIVO.3.M.B_meme_format.meme
Transfac format	HNF6.H12INVIVO.3.M.B_transfac_format.txt
Homer format	HNF6.H12INVIVO.3.M.B_homer_format_0.001.txt HNF6.H12INVIVO.3.M.B_homer_format_0.0005.txt HNF6.H12INVIVO.3.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	123.25	61.25	78.25	78.25
02	43.75	86.75	112.75	97.75
03	15.0	7.0	26.0	293.0
04	341.0	0.0	0.0	0.0
05	0.0	0.0	0.0	341.0
06	0.0	0.0	0.0	341.0
07	0.0	0.0	341.0	0.0
08	341.0	0.0	0.0	0.0
09	0.0	0.0	0.0	341.0
10	0.0	81.0	0.0	260.0
11	81.0	1.0	247.0	12.0
12	260.0	31.0	40.0	10.0
13	25.25	84.25	37.25	194.25
14	69.5	88.5	57.5	125.5

PFM

	A	C	G	T
01	0.361	0.18	0.229	0.229
02	0.128	0.254	0.331	0.287
03	0.044	0.021	0.076	0.859
04	1.0	0.0	0.0	0.0
05	0.0	0.0	0.0	1.0
06	0.0	0.0	0.0	1.0
07	0.0	0.0	1.0	0.0
08	1.0	0.0	0.0	0.0
09	0.0	0.0	0.0	1.0
10	0.0	0.238	0.0	0.762
11	0.238	0.003	0.724	0.035
12	0.762	0.091	0.117	0.029
13	0.074	0.247	0.109	0.57
14	0.204	0.26	0.169	0.368

PWM

	A	C	G	T
01	0.363	-0.324	-0.084	-0.084
02	-0.651	0.017	0.275	0.135
03	-1.662	-2.327	-1.15	1.223
04	1.374	-4.086	-4.086	-4.086
05	-4.086	-4.086	-4.086	1.374
06	-4.086	-4.086	-4.086	1.374
07	-4.086	-4.086	1.374	-4.086
08	1.374	-4.086	-4.086	-4.086
09	-4.086	-4.086	-4.086	1.374
10	-4.086	-0.05	-4.086	1.104
11	-0.05	-3.563	1.053	-1.863
12	1.104	-0.983	-0.738	-2.024
13	-1.178	-0.012	-0.807	0.814
14	-0.2	0.037	-0.386	0.381

Standard thresholds

P-value	Threshold
0.001	1.42516
0.0005	2.87758
0.0001	5.846065