HNF6.H12INVIVO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF6.H12INVIVO.1.S.B
Gene (human)	ONECUT1 (GeneCards)
Gene synonyms (human)	HNF6, HNF6A
Gene (mouse)	Onecut1
Gene synonyms (mouse)	Hnf6, Hnf6a
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	11
Consensus	nbATCGATYdn
GC content	41.39%
Information content (bits; total / per base)	12.634 / 1.149
Data sources	HT-SELEX
Aligned words	9146

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	12 (54)	0.97	0.982	0.933	0.954	0.931	0.947	3.456	3.721	496.038	705.538

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.986	0.974	0.982	0.969	0.981	0.962
Overall, 10 experiments	best	0.999	0.997	0.998	0.997	0.997	0.995
Methyl HT-SELEX, 3 experiments	median	0.978	0.962	0.978	0.959	0.979	0.96
Methyl HT-SELEX, 3 experiments	best	0.98	0.963	0.979	0.961	0.983	0.964
Non-Methyl HT-SELEX, 7 experiments	median	0.995	0.99	0.993	0.987	0.988	0.981
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.997	0.998	0.997	0.997	0.995

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.1
HGNC	HGNC:8138
MGI	MGI:1196423
EntrezGene (human)	GeneID:3175 (SSTAR profile)
EntrezGene (mouse)	GeneID:15379 (SSTAR profile)
UniProt ID (human)	HNF6_HUMAN
UniProt ID (mouse)	HNF6_MOUSE
UniProt AC (human)	Q9UBC0 (TFClass)
UniProt AC (mouse)	O08755 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 12 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	HNF6.H12INVIVO.1.S.B.pcm
PWM	HNF6.H12INVIVO.1.S.B.pwm
PFM	HNF6.H12INVIVO.1.S.B.pfm
Alignment	HNF6.H12INVIVO.1.S.B.words.tsv
Threshold to P-value map	HNF6.H12INVIVO.1.S.B.thr
Motif in other formats
JASPAR format	HNF6.H12INVIVO.1.S.B_jaspar_format.txt
MEME format	HNF6.H12INVIVO.1.S.B_meme_format.meme
Transfac format	HNF6.H12INVIVO.1.S.B_transfac_format.txt
Homer format	HNF6.H12INVIVO.1.S.B_homer_format_0.001.txt HNF6.H12INVIVO.1.S.B_homer_format_0.0005.txt HNF6.H12INVIVO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1595.25	2250.25	2995.25	2305.25
02	896.75	1342.75	2585.75	4320.75
03	8723.0	18.0	303.0	102.0
04	3.0	0.0	0.0	9143.0
05	0.0	8747.0	0.0	399.0
06	0.0	0.0	9146.0	0.0
07	9146.0	0.0	0.0	0.0
08	9.0	236.0	10.0	8891.0
09	165.0	3283.0	180.0	5518.0
10	1715.75	930.75	4834.75	1664.75
11	2794.25	1871.25	2907.25	1573.25

PFM

	A	C	G	T
01	0.174	0.246	0.327	0.252
02	0.098	0.147	0.283	0.472
03	0.954	0.002	0.033	0.011
04	0.0	0.0	0.0	1.0
05	0.0	0.956	0.0	0.044
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.001	0.026	0.001	0.972
09	0.018	0.359	0.02	0.603
10	0.188	0.102	0.529	0.182
11	0.306	0.205	0.318	0.172

PWM

	A	C	G	T
01	-0.36	-0.016	0.27	0.008
02	-0.934	-0.532	0.123	0.636
03	1.338	-4.726	-2.015	-3.089
04	-6.072	-6.911	-6.911	1.385
05	-6.911	1.341	-6.911	-1.741
06	-6.911	-6.911	1.386	-6.911
07	1.386	-6.911	-6.911	-6.911
08	-5.313	-2.262	-5.228	1.357
09	-2.616	0.361	-2.53	0.88
10	-0.287	-0.897	0.748	-0.317
11	0.2	-0.2	0.24	-0.373

Standard thresholds

P-value	Threshold
0.001	2.57043
0.0005	4.52404
0.0001	7.534995