HNF6.H12INVITRO.2.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF6.H12INVITRO.2.S.B
Gene (human)	ONECUT1 (GeneCards)
Gene synonyms (human)	HNF6, HNF6A
Gene (mouse)	Onecut1
Gene synonyms (mouse)	Hnf6, Hnf6a
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	15
Consensus	nnbKATCGATCGRYn
GC content	47.35%
Information content (bits; total / per base)	17.235 / 1.149
Data sources	HT-SELEX
Aligned words	2081

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	12 (54)	0.632	0.681	0.578	0.651	0.79	0.826	2.615	3.103	199.784	298.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.986	0.977	0.966	0.951	0.946	0.921
Overall, 10 experiments	best	0.999	0.998	0.998	0.997	0.998	0.996
Methyl HT-SELEX, 3 experiments	median	0.979	0.963	0.965	0.945	0.936	0.91
Methyl HT-SELEX, 3 experiments	best	0.98	0.968	0.968	0.95	0.955	0.931
Non-Methyl HT-SELEX, 7 experiments	median	0.994	0.99	0.992	0.986	0.979	0.971
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.998	0.998	0.997	0.998	0.996

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.1
HGNC	HGNC:8138
MGI	MGI:1196423
EntrezGene (human)	GeneID:3175 (SSTAR profile)
EntrezGene (mouse)	GeneID:15379 (SSTAR profile)
UniProt ID (human)	HNF6_HUMAN
UniProt ID (mouse)	HNF6_MOUSE
UniProt AC (human)	Q9UBC0 (TFClass)
UniProt AC (mouse)	O08755 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 12 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	HNF6.H12INVITRO.2.S.B.pcm
PWM	HNF6.H12INVITRO.2.S.B.pwm
PFM	HNF6.H12INVITRO.2.S.B.pfm
Alignment	HNF6.H12INVITRO.2.S.B.words.tsv
Threshold to P-value map	HNF6.H12INVITRO.2.S.B.thr
Motif in other formats
JASPAR format	HNF6.H12INVITRO.2.S.B_jaspar_format.txt
MEME format	HNF6.H12INVITRO.2.S.B_meme_format.meme
Transfac format	HNF6.H12INVITRO.2.S.B_transfac_format.txt
Homer format	HNF6.H12INVITRO.2.S.B_homer_format_0.001.txt HNF6.H12INVITRO.2.S.B_homer_format_0.0005.txt HNF6.H12INVITRO.2.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	435.5	590.5	647.5	407.5
02	383.5	556.5	778.5	362.5
03	177.0	648.0	652.0	604.0
04	359.0	42.0	409.0	1271.0
05	2080.0	1.0	0.0	0.0
06	0.0	0.0	0.0	2081.0
07	0.0	2081.0	0.0	0.0
08	0.0	0.0	2081.0	0.0
09	2081.0	0.0	0.0	0.0
10	0.0	0.0	0.0	2081.0
11	0.0	1967.0	0.0	114.0
12	42.0	53.0	1959.0	27.0
13	1424.0	240.0	284.0	133.0
14	185.0	280.0	261.0	1355.0
15	362.0	601.0	648.0	470.0

PFM

	A	C	G	T
01	0.209	0.284	0.311	0.196
02	0.184	0.267	0.374	0.174
03	0.085	0.311	0.313	0.29
04	0.173	0.02	0.197	0.611
05	1.0	0.0	0.0	0.0
06	0.0	0.0	0.0	1.0
07	0.0	1.0	0.0	0.0
08	0.0	0.0	1.0	0.0
09	1.0	0.0	0.0	0.0
10	0.0	0.0	0.0	1.0
11	0.0	0.945	0.0	0.055
12	0.02	0.025	0.941	0.013
13	0.684	0.115	0.136	0.064
14	0.089	0.135	0.125	0.651
15	0.174	0.289	0.311	0.226

PWM

	A	C	G	T
01	-0.177	0.126	0.218	-0.243
02	-0.304	0.067	0.402	-0.36
03	-1.071	0.219	0.225	0.149
04	-0.369	-2.476	-0.24	0.891
05	1.383	-5.19	-5.611	-5.611
06	-5.611	-5.611	-5.611	1.384
07	-5.611	1.384	-5.611	-5.611
08	-5.611	-5.611	1.384	-5.611
09	1.384	-5.611	-5.611	-5.611
10	-5.611	-5.611	-5.611	1.384
11	-5.611	1.327	-5.611	-1.505
12	-2.476	-2.252	1.323	-2.894
13	1.005	-0.769	-0.602	-1.353
14	-1.027	-0.616	-0.686	0.955
15	-0.361	0.144	0.219	-0.101

Standard thresholds

P-value	Threshold
0.001	-0.81899
0.0005	1.021765
0.0001	4.68326