HNF6.H12INVITRO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF6.H12INVITRO.1.S.B
Gene (human)	ONECUT1 (GeneCards)
Gene synonyms (human)	HNF6, HNF6A
Gene (mouse)	Onecut1
Gene synonyms (mouse)	Hnf6, Hnf6a
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	11
Consensus	nTATCGATTnn
GC content	35.64%
Information content (bits; total / per base)	14.773 / 1.343
Data sources	HT-SELEX
Aligned words	4547

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	12 (54)	0.924	0.964	0.898	0.932	0.926	0.958	3.738	4.012	412.323	651.201

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.989	0.979	0.99	0.98	0.989	0.979
Overall, 10 experiments	best	0.999	0.997	0.998	0.997	0.997	0.996
Methyl HT-SELEX, 3 experiments	median	0.983	0.969	0.986	0.971	0.989	0.976
Methyl HT-SELEX, 3 experiments	best	0.984	0.969	0.989	0.976	0.992	0.981
Non-Methyl HT-SELEX, 7 experiments	median	0.995	0.99	0.992	0.986	0.988	0.981
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.997	0.998	0.997	0.997	0.996

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.1
HGNC	HGNC:8138
MGI	MGI:1196423
EntrezGene (human)	GeneID:3175 (SSTAR profile)
EntrezGene (mouse)	GeneID:15379 (SSTAR profile)
UniProt ID (human)	HNF6_HUMAN
UniProt ID (mouse)	HNF6_MOUSE
UniProt AC (human)	Q9UBC0 (TFClass)
UniProt AC (mouse)	O08755 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 12 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	HNF6.H12INVITRO.1.S.B.pcm
PWM	HNF6.H12INVITRO.1.S.B.pwm
PFM	HNF6.H12INVITRO.1.S.B.pfm
Alignment	HNF6.H12INVITRO.1.S.B.words.tsv
Threshold to P-value map	HNF6.H12INVITRO.1.S.B.thr
Motif in other formats
JASPAR format	HNF6.H12INVITRO.1.S.B_jaspar_format.txt
MEME format	HNF6.H12INVITRO.1.S.B_meme_format.meme
Transfac format	HNF6.H12INVITRO.1.S.B_transfac_format.txt
Homer format	HNF6.H12INVITRO.1.S.B_homer_format_0.001.txt HNF6.H12INVITRO.1.S.B_homer_format_0.0005.txt HNF6.H12INVITRO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1075.25	861.25	1114.25	1496.25
02	74.0	36.0	0.0	4437.0
03	4547.0	0.0	0.0	0.0
04	0.0	0.0	0.0	4547.0
05	0.0	4431.0	0.0	116.0
06	0.0	0.0	4547.0	0.0
07	4547.0	0.0	0.0	0.0
08	0.0	0.0	0.0	4547.0
09	0.0	2023.0	0.0	2524.0
10	967.0	714.0	1684.0	1182.0
11	1155.75	938.75	1474.75	977.75

PFM

	A	C	G	T
01	0.236	0.189	0.245	0.329
02	0.016	0.008	0.0	0.976
03	1.0	0.0	0.0	0.0
04	0.0	0.0	0.0	1.0
05	0.0	0.974	0.0	0.026
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.445	0.0	0.555
10	0.213	0.157	0.37	0.26
11	0.254	0.206	0.324	0.215

PWM

	A	C	G	T
01	-0.056	-0.277	-0.02	0.274
02	-2.706	-3.397	-6.293	1.36
03	1.385	-6.293	-6.293	-6.293
04	-6.293	-6.293	-6.293	1.385
05	-6.293	1.359	-6.293	-2.266
06	-6.293	-6.293	1.385	-6.293
07	1.385	-6.293	-6.293	-6.293
08	-6.293	-6.293	-6.293	1.385
09	-6.293	0.576	-6.293	0.797
10	-0.161	-0.464	0.392	0.039
11	0.017	-0.191	0.26	-0.15

Standard thresholds

P-value	Threshold
0.001	-0.849525
0.0005	2.427975
0.0001	5.62932