HNF6.H12INVITRO.0.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF6.H12INVITRO.0.PM.A
Gene (human)	ONECUT1 (GeneCards)
Gene synonyms (human)	HNF6, HNF6A
Gene (mouse)	Onecut1
Gene synonyms (mouse)	Hnf6, Hnf6a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	10
Consensus	bYATYGATYd
GC content	29.35%
Information content (bits; total / per base)	10.998 / 1.1
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	895

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	12 (54)	0.966	0.978	0.927	0.948	0.949	0.967	3.886	4.414	513.883	747.26

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.993	0.986	0.991	0.983	0.987	0.977
Overall, 10 experiments	best	0.998	0.996	0.998	0.996	0.997	0.995
Methyl HT-SELEX, 3 experiments	median	0.995	0.991	0.995	0.989	0.994	0.988
Methyl HT-SELEX, 3 experiments	best	0.998	0.996	0.998	0.996	0.997	0.995
Non-Methyl HT-SELEX, 7 experiments	median	0.989	0.978	0.988	0.977	0.985	0.972
Non-Methyl HT-SELEX, 7 experiments	best	0.996	0.993	0.995	0.991	0.993	0.988

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.1
HGNC	HGNC:8138
MGI	MGI:1196423
EntrezGene (human)	GeneID:3175 (SSTAR profile)
EntrezGene (mouse)	GeneID:15379 (SSTAR profile)
UniProt ID (human)	HNF6_HUMAN
UniProt ID (mouse)	HNF6_MOUSE
UniProt AC (human)	Q9UBC0 (TFClass)
UniProt AC (mouse)	O08755 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 12 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	HNF6.H12INVITRO.0.PM.A.pcm
PWM	HNF6.H12INVITRO.0.PM.A.pwm
PFM	HNF6.H12INVITRO.0.PM.A.pfm
Alignment	HNF6.H12INVITRO.0.PM.A.words.tsv
Threshold to P-value map	HNF6.H12INVITRO.0.PM.A.thr
Motif in other formats
JASPAR format	HNF6.H12INVITRO.0.PM.A_jaspar_format.txt
MEME format	HNF6.H12INVITRO.0.PM.A_meme_format.meme
Transfac format	HNF6.H12INVITRO.0.PM.A_transfac_format.txt
Homer format	HNF6.H12INVITRO.0.PM.A_homer_format_0.001.txt HNF6.H12INVITRO.0.PM.A_homer_format_0.0005.txt HNF6.H12INVITRO.0.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	124.0	170.0	212.0	389.0
02	47.0	185.0	113.0	550.0
03	847.0	20.0	11.0	17.0
04	10.0	10.0	26.0	849.0
05	9.0	258.0	10.0	618.0
06	3.0	6.0	872.0	14.0
07	868.0	9.0	9.0	9.0
08	13.0	45.0	9.0	828.0
09	12.0	306.0	6.0	571.0
10	150.0	136.0	214.0	395.0

PFM

	A	C	G	T
01	0.139	0.19	0.237	0.435
02	0.053	0.207	0.126	0.615
03	0.946	0.022	0.012	0.019
04	0.011	0.011	0.029	0.949
05	0.01	0.288	0.011	0.691
06	0.003	0.007	0.974	0.016
07	0.97	0.01	0.01	0.01
08	0.015	0.05	0.01	0.925
09	0.013	0.342	0.007	0.638
10	0.168	0.152	0.239	0.441

PWM

	A	C	G	T
01	-0.584	-0.272	-0.054	0.55
02	-1.532	-0.189	-0.676	0.895
03	1.326	-2.341	-2.877	-2.49
04	-2.959	-2.959	-2.097	1.328
05	-3.048	0.141	-2.959	1.011
06	-3.871	-3.377	1.355	-2.664
07	1.35	-3.048	-3.048	-3.048
08	-2.73	-1.574	-3.048	1.303
09	-2.801	0.311	-3.377	0.932
10	-0.396	-0.493	-0.044	0.565

Standard thresholds

P-value	Threshold
0.001	4.437605
0.0005	5.230235
0.0001	7.566145