HNF6.H12CORE.3.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF6.H12CORE.3.M.B
Gene (human)	ONECUT1 (GeneCards)
Gene synonyms (human)	HNF6, HNF6A
Gene (mouse)	Onecut1
Gene synonyms (mouse)	Hnf6, Hnf6a
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	B

Motif length	15
Consensus	nvKTATTGATTRRTb
GC content	28.33%
Information content (bits; total / per base)	19.196 / 1.28
Data sources	Methyl-HT-SELEX
Aligned words	1173

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	12 (54)	0.747	0.832	0.723	0.804	0.848	0.898	3.412	3.934	320.93	464.409

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.988	0.981	0.973	0.96	0.946	0.927
Overall, 10 experiments	best	0.999	0.997	0.998	0.997	0.998	0.996
Methyl HT-SELEX, 3 experiments	median	0.995	0.991	0.993	0.988	0.976	0.968
Methyl HT-SELEX, 3 experiments	best	0.999	0.997	0.998	0.997	0.998	0.996
Non-Methyl HT-SELEX, 7 experiments	median	0.983	0.971	0.96	0.939	0.927	0.903
Non-Methyl HT-SELEX, 7 experiments	best	0.995	0.991	0.986	0.98	0.972	0.959

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.1
HGNC	HGNC:8138
MGI	MGI:1196423
EntrezGene (human)	GeneID:3175 (SSTAR profile)
EntrezGene (mouse)	GeneID:15379 (SSTAR profile)
UniProt ID (human)	HNF6_HUMAN
UniProt ID (mouse)	HNF6_MOUSE
UniProt AC (human)	Q9UBC0 (TFClass)
UniProt AC (mouse)	O08755 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 12 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	HNF6.H12CORE.3.M.B.pcm
PWM	HNF6.H12CORE.3.M.B.pwm
PFM	HNF6.H12CORE.3.M.B.pfm
Alignment	HNF6.H12CORE.3.M.B.words.tsv
Threshold to P-value map	HNF6.H12CORE.3.M.B.thr
Motif in other formats
JASPAR format	HNF6.H12CORE.3.M.B_jaspar_format.txt
MEME format	HNF6.H12CORE.3.M.B_meme_format.meme
Transfac format	HNF6.H12CORE.3.M.B_transfac_format.txt
Homer format	HNF6.H12CORE.3.M.B_homer_format_0.001.txt HNF6.H12CORE.3.M.B_homer_format_0.0005.txt HNF6.H12CORE.3.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	300.5	312.5	331.5	228.5
02	342.0	236.0	444.0	151.0
03	58.0	39.0	518.0	558.0
04	0.0	0.0	0.0	1173.0
05	1173.0	0.0	0.0	0.0
06	0.0	0.0	0.0	1173.0
07	0.0	0.0	0.0	1173.0
08	0.0	0.0	1173.0	0.0
09	1173.0	0.0	0.0	0.0
10	0.0	0.0	0.0	1173.0
11	0.0	82.0	0.0	1091.0
12	189.0	3.0	888.0	93.0
13	824.0	25.0	206.0	118.0
14	27.0	165.0	51.0	930.0
15	160.5	278.5	232.5	501.5

PFM

	A	C	G	T
01	0.256	0.266	0.283	0.195
02	0.292	0.201	0.379	0.129
03	0.049	0.033	0.442	0.476
04	0.0	0.0	0.0	1.0
05	1.0	0.0	0.0	0.0
06	0.0	0.0	0.0	1.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	1.0	0.0
09	1.0	0.0	0.0	0.0
10	0.0	0.0	0.0	1.0
11	0.0	0.07	0.0	0.93
12	0.161	0.003	0.757	0.079
13	0.702	0.021	0.176	0.101
14	0.023	0.141	0.043	0.793
15	0.137	0.237	0.198	0.428

PWM

	A	C	G	T
01	0.024	0.063	0.122	-0.248
02	0.153	-0.216	0.413	-0.658
03	-1.597	-1.979	0.566	0.64
04	-5.118	-5.118	-5.118	1.382
05	1.382	-5.118	-5.118	-5.118
06	-5.118	-5.118	-5.118	1.382
07	-5.118	-5.118	-5.118	1.382
08	-5.118	-5.118	1.382	-5.118
09	1.382	-5.118	-5.118	-5.118
10	-5.118	-5.118	-5.118	1.382
11	-5.118	-1.259	-5.118	1.309
12	-0.436	-4.125	1.104	-1.136
13	1.029	-2.4	-0.351	-0.901
14	-2.328	-0.57	-1.721	1.15
15	-0.598	-0.051	-0.231	0.534

Standard thresholds

P-value	Threshold
0.001	-2.01994
0.0005	-0.24022
0.0001	3.73527