HNF6.H12CORE.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF6.H12CORE.1.S.B
Gene (human)	ONECUT1 (GeneCards)
Gene synonyms (human)	HNF6, HNF6A
Gene (mouse)	Onecut1
Gene synonyms (mouse)	Hnf6, Hnf6a
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	11
Consensus	nWATCGATYdn
GC content	37.01%
Information content (bits; total / per base)	13.546 / 1.231
Data sources	HT-SELEX
Aligned words	7303

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	12 (54)	0.954	0.971	0.927	0.951	0.939	0.961	3.646	3.852	495.345	704.553

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.989	0.979	0.985	0.973	0.985	0.968
Overall, 10 experiments	best	0.999	0.997	0.998	0.997	0.997	0.996
Methyl HT-SELEX, 3 experiments	median	0.979	0.966	0.979	0.961	0.983	0.966
Methyl HT-SELEX, 3 experiments	best	0.984	0.97	0.979	0.963	0.986	0.969
Non-Methyl HT-SELEX, 7 experiments	median	0.995	0.99	0.993	0.987	0.989	0.982
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.997	0.998	0.997	0.997	0.996

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.1
HGNC	HGNC:8138
MGI	MGI:1196423
EntrezGene (human)	GeneID:3175 (SSTAR profile)
EntrezGene (mouse)	GeneID:15379 (SSTAR profile)
UniProt ID (human)	HNF6_HUMAN
UniProt ID (mouse)	HNF6_MOUSE
UniProt AC (human)	Q9UBC0 (TFClass)
UniProt AC (mouse)	O08755 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 12 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	HNF6.H12CORE.1.S.B.pcm
PWM	HNF6.H12CORE.1.S.B.pwm
PFM	HNF6.H12CORE.1.S.B.pfm
Alignment	HNF6.H12CORE.1.S.B.words.tsv
Threshold to P-value map	HNF6.H12CORE.1.S.B.thr
Motif in other formats
JASPAR format	HNF6.H12CORE.1.S.B_jaspar_format.txt
MEME format	HNF6.H12CORE.1.S.B_meme_format.meme
Transfac format	HNF6.H12CORE.1.S.B_transfac_format.txt
Homer format	HNF6.H12CORE.1.S.B_homer_format_0.001.txt HNF6.H12CORE.1.S.B_homer_format_0.0005.txt HNF6.H12CORE.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1771.0	1409.0	1663.0	2460.0
02	1394.0	1115.0	51.0	4743.0
03	7303.0	0.0	0.0	0.0
04	0.0	0.0	0.0	7303.0
05	0.0	7117.0	0.0	186.0
06	0.0	0.0	7303.0	0.0
07	7303.0	0.0	0.0	0.0
08	0.0	0.0	0.0	7303.0
09	45.0	3332.0	50.0	3876.0
10	1438.0	1136.0	2846.0	1883.0
11	1945.75	1460.75	2249.75	1646.75

PFM

	A	C	G	T
01	0.243	0.193	0.228	0.337
02	0.191	0.153	0.007	0.649
03	1.0	0.0	0.0	0.0
04	0.0	0.0	0.0	1.0
05	0.0	0.975	0.0	0.025
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.006	0.456	0.007	0.531
10	0.197	0.156	0.39	0.258
11	0.266	0.2	0.308	0.225

PWM

	A	C	G	T
01	-0.03	-0.259	-0.093	0.298
02	-0.269	-0.492	-3.536	0.954
03	1.385	-6.712	-6.712	-6.712
04	-6.712	-6.712	-6.712	1.385
05	-6.712	1.36	-6.712	-2.273
06	-6.712	-6.712	1.385	-6.712
07	1.385	-6.712	-6.712	-6.712
08	-6.712	-6.712	-6.712	1.385
09	-3.656	0.601	-3.555	0.752
10	-0.238	-0.474	0.443	0.031
11	0.064	-0.223	0.209	-0.103

Standard thresholds

P-value	Threshold
0.001	1.00739
0.0005	1.932135
0.0001	6.479445