HNF1B.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF1B.H12INVITRO.0.PS.A
Gene (human)	HNF1B (GeneCards)
Gene synonyms (human)	TCF2
Gene (mouse)	Hnf1b
Gene synonyms (mouse)	Hnf-1b, Tcf2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	15
Consensus	dRYWAATGATTRRYh
GC content	27.78%
Information content (bits; total / per base)	14.99 / 0.999
Data sources	ChIP-Seq + HT-SELEX
Aligned words	991

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (24)	0.954	0.982	0.933	0.966	0.969	0.988	5.822	6.347	266.839	479.796
Mouse	4 (27)	0.977	0.981	0.956	0.966	0.978	0.984	5.655	6.315	565.276	764.409

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	1.0	1.0	0.997	0.997	0.853	0.884
Non-Methyl HT-SELEX, 2 experiments	best	1	1	1.0	1.0	0.924	0.939

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.931	0.466	0.928	0.568
batch 2	0.898	0.594	0.895	0.656

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	HNF1-like {3.1.10.7} (TFClass)
TFClass ID	TFClass: 3.1.10.7.2
HGNC	HGNC:11630
MGI	MGI:98505
EntrezGene (human)	GeneID:6928 (SSTAR profile)
EntrezGene (mouse)	GeneID:21410 (SSTAR profile)
UniProt ID (human)	HNF1B_HUMAN
UniProt ID (mouse)	HNF1B_MOUSE
UniProt AC (human)	P35680 (TFClass)
UniProt AC (mouse)	P27889 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 4 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	HNF1B.H12INVITRO.0.PS.A.pcm
PWM	HNF1B.H12INVITRO.0.PS.A.pwm
PFM	HNF1B.H12INVITRO.0.PS.A.pfm
Alignment	HNF1B.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	HNF1B.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	HNF1B.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	HNF1B.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	HNF1B.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	HNF1B.H12INVITRO.0.PS.A_homer_format_0.001.txt HNF1B.H12INVITRO.0.PS.A_homer_format_0.0005.txt HNF1B.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	287.0	67.0	416.0	221.0
02	198.0	52.0	684.0	57.0
03	35.0	120.0	88.0	748.0
04	127.0	82.0	57.0	725.0
05	936.0	1.0	51.0	3.0
06	913.0	63.0	4.0	11.0
07	61.0	15.0	1.0	914.0
08	273.0	0.0	718.0	0.0
09	827.0	6.0	35.0	123.0
10	40.0	10.0	114.0	827.0
11	6.0	28.0	2.0	955.0
12	720.0	55.0	111.0	105.0
13	773.0	77.0	112.0	29.0
14	76.0	661.0	53.0	201.0
15	239.0	374.0	73.0	305.0

PFM

	A	C	G	T
01	0.29	0.068	0.42	0.223
02	0.2	0.052	0.69	0.058
03	0.035	0.121	0.089	0.755
04	0.128	0.083	0.058	0.732
05	0.945	0.001	0.051	0.003
06	0.921	0.064	0.004	0.011
07	0.062	0.015	0.001	0.922
08	0.275	0.0	0.725	0.0
09	0.835	0.006	0.035	0.124
10	0.04	0.01	0.115	0.835
11	0.006	0.028	0.002	0.964
12	0.727	0.055	0.112	0.106
13	0.78	0.078	0.113	0.029
14	0.077	0.667	0.053	0.203
15	0.241	0.377	0.074	0.308

PWM

	A	C	G	T
01	0.146	-1.289	0.515	-0.113
02	-0.222	-1.535	1.011	-1.446
03	-1.916	-0.718	-1.023	1.1
04	-0.662	-1.092	-1.446	1.069
05	1.324	-4.517	-1.554	-3.967
06	1.299	-1.349	-3.775	-2.976
07	-1.381	-2.702	-4.517	1.3
08	0.096	-4.974	1.06	-4.974
09	1.201	-3.475	-1.916	-0.693
10	-1.788	-3.058	-0.768	1.201
11	-3.475	-2.127	-4.204	1.344
12	1.062	-1.481	-0.794	-0.849
13	1.133	-1.153	-0.786	-2.094
14	-1.166	0.977	-1.517	-0.208
15	-0.036	0.409	-1.206	0.207

Standard thresholds

P-value	Threshold
0.001	3.14136
0.0005	4.26981
0.0001	6.61866