HNF1B.H12CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF1B.H12CORE.0.PS.A
Gene (human)	HNF1B (GeneCards)
Gene synonyms (human)	TCF2
Gene (mouse)	Hnf1b
Gene synonyms (mouse)	Hnf-1b, Tcf2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	15
Consensus	dRTWAATGATTRAYh
GC content	26.05%
Information content (bits; total / per base)	15.226 / 1.015
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (24)	0.953	0.979	0.928	0.958	0.97	0.987	5.825	6.194	265.041	479.237
Mouse	4 (27)	0.977	0.984	0.957	0.97	0.982	0.988	5.803	6.473	574.678	772.018

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	1.0	1.0	0.998	0.997	0.848	0.882
Non-Methyl HT-SELEX, 2 experiments	best	1	1	1.0	1.0	0.92	0.938

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.942	0.434	0.937	0.564
batch 2	0.913	0.62	0.913	0.63

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	HNF1-like {3.1.10.7} (TFClass)
TFClass ID	TFClass: 3.1.10.7.2
HGNC	HGNC:11630
MGI	MGI:98505
EntrezGene (human)	GeneID:6928 (SSTAR profile)
EntrezGene (mouse)	GeneID:21410 (SSTAR profile)
UniProt ID (human)	HNF1B_HUMAN
UniProt ID (mouse)	HNF1B_MOUSE
UniProt AC (human)	P35680 (TFClass)
UniProt AC (mouse)	P27889 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 4 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	HNF1B.H12CORE.0.PS.A.pcm
PWM	HNF1B.H12CORE.0.PS.A.pwm
PFM	HNF1B.H12CORE.0.PS.A.pfm
Alignment	HNF1B.H12CORE.0.PS.A.words.tsv
Threshold to P-value map	HNF1B.H12CORE.0.PS.A.thr
Motif in other formats
JASPAR format	HNF1B.H12CORE.0.PS.A_jaspar_format.txt
MEME format	HNF1B.H12CORE.0.PS.A_meme_format.meme
Transfac format	HNF1B.H12CORE.0.PS.A_transfac_format.txt
Homer format	HNF1B.H12CORE.0.PS.A_homer_format_0.001.txt HNF1B.H12CORE.0.PS.A_homer_format_0.0005.txt HNF1B.H12CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	326.0	78.0	347.0	249.0
02	163.0	29.0	733.0	75.0
03	25.0	83.0	69.0	823.0
04	133.0	72.0	35.0	760.0
05	969.0	2.0	23.0	6.0
06	941.0	44.0	3.0	12.0
07	41.0	12.0	4.0	943.0
08	397.0	0.0	603.0	0.0
09	778.0	14.0	49.0	159.0
10	63.0	24.0	113.0	800.0
11	13.0	40.0	1.0	946.0
12	699.0	59.0	137.0	105.0
13	825.0	83.0	61.0	31.0
14	71.0	704.0	39.0	186.0
15	235.0	361.0	86.0	318.0

PFM

	A	C	G	T
01	0.326	0.078	0.347	0.249
02	0.163	0.029	0.733	0.075
03	0.025	0.083	0.069	0.823
04	0.133	0.072	0.035	0.76
05	0.969	0.002	0.023	0.006
06	0.941	0.044	0.003	0.012
07	0.041	0.012	0.004	0.943
08	0.397	0.0	0.603	0.0
09	0.778	0.014	0.049	0.159
10	0.063	0.024	0.113	0.8
11	0.013	0.04	0.001	0.946
12	0.699	0.059	0.137	0.105
13	0.825	0.083	0.061	0.031
14	0.071	0.704	0.039	0.186
15	0.235	0.361	0.086	0.318

PWM

	A	C	G	T
01	0.264	-1.15	0.326	-0.004
02	-0.424	-2.103	1.071	-1.188
03	-2.243	-1.089	-1.27	1.187
04	-0.625	-1.228	-1.925	1.107
05	1.35	-4.213	-2.32	-3.484
06	1.32	-1.706	-3.975	-2.909
07	-1.774	-2.909	-3.783	1.323
08	0.46	-4.982	0.876	-4.982
09	1.131	-2.773	-1.602	-0.449
10	-1.358	-2.281	-0.786	1.158
11	-2.839	-1.797	-4.525	1.326
12	1.024	-1.422	-0.596	-0.858
13	1.189	-1.089	-1.39	-2.04
14	-1.242	1.031	-1.821	-0.293
15	-0.061	0.365	-1.054	0.239

Standard thresholds

P-value	Threshold
0.001	3.04256
0.0005	4.17751
0.0001	6.54806