MotifHNF1B.H12CORE.0.PS.A
Gene (human)HNF1B
(GeneCards)
Gene synonyms (human)TCF2
Gene (mouse)Hnf1b
Gene synonyms (mouse)Hnf-1b, Tcf2
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length15
ConsensusdRTWAATGATTRAYh
GC content26.05%
Information content (bits; total / per base)15.226 / 1.015
Data sourcesChIP-Seq + HT-SELEX
Aligned words1000

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 4 (24) 0.953 0.979 0.928 0.958 0.97 0.987 5.825 6.194 265.041 479.237
Mouse 4 (27) 0.977 0.984 0.957 0.97 0.982 0.988 5.803 6.473 574.678 772.018

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Non-Methyl HT-SELEX, 2 experiments median 1.0 1.0 0.998 0.997 0.848 0.882
best 1 1 1.0 1.0 0.92 0.938

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.942 0.434 0.937 0.564
batch 2 0.913 0.62 0.913 0.63
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyPOU {3.1.10} (TFClass)
TF subfamilyHNF1-like {3.1.10.7} (TFClass)
TFClass IDTFClass: 3.1.10.7.2
HGNCHGNC:11630
MGIMGI:98505
EntrezGene (human)GeneID:6928
(SSTAR profile)
EntrezGene (mouse)GeneID:21410
(SSTAR profile)
UniProt ID (human)HNF1B_HUMAN
UniProt ID (mouse)HNF1B_MOUSE
UniProt AC (human)P35680
(TFClass)
UniProt AC (mouse)P27889
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 4 human, 4 mouse
HT-SELEX 2
Methyl-HT-SELEX 0
PCM
ACGT
01326.078.0347.0249.0
02163.029.0733.075.0
0325.083.069.0823.0
04133.072.035.0760.0
05969.02.023.06.0
06941.044.03.012.0
0741.012.04.0943.0
08397.00.0603.00.0
09778.014.049.0159.0
1063.024.0113.0800.0
1113.040.01.0946.0
12699.059.0137.0105.0
13825.083.061.031.0
1471.0704.039.0186.0
15235.0361.086.0318.0
PFM
ACGT
010.3260.0780.3470.249
020.1630.0290.7330.075
030.0250.0830.0690.823
040.1330.0720.0350.76
050.9690.0020.0230.006
060.9410.0440.0030.012
070.0410.0120.0040.943
080.3970.00.6030.0
090.7780.0140.0490.159
100.0630.0240.1130.8
110.0130.040.0010.946
120.6990.0590.1370.105
130.8250.0830.0610.031
140.0710.7040.0390.186
150.2350.3610.0860.318
PWM
ACGT
010.264-1.150.326-0.004
02-0.424-2.1031.071-1.188
03-2.243-1.089-1.271.187
04-0.625-1.228-1.9251.107
051.35-4.213-2.32-3.484
061.32-1.706-3.975-2.909
07-1.774-2.909-3.7831.323
080.46-4.9820.876-4.982
091.131-2.773-1.602-0.449
10-1.358-2.281-0.7861.158
11-2.839-1.797-4.5251.326
121.024-1.422-0.596-0.858
131.189-1.089-1.39-2.04
14-1.2421.031-1.821-0.293
15-0.0610.365-1.0540.239
Standard thresholds
P-value Threshold
0.001 3.04256
0.0005 4.17751
0.0001 6.54806