HNF1A.H12CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HNF1A.H12CORE.0.PS.A
Gene (human)	HNF1A (GeneCards)
Gene synonyms (human)	TCF1
Gene (mouse)	Hnf1a
Gene synonyms (mouse)	Hnf-1, Hnf-1a, Tcf1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	15
Consensus	dRTWAATGWTTWMYh
GC content	27.07%
Information content (bits; total / per base)	15.269 / 1.018
Data sources	ChIP-Seq + HT-SELEX
Aligned words	999

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (51)	0.768	0.98	0.716	0.963	0.866	0.983	4.639	6.005	71.721	673.276

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	1.0	1.0	1.0	1.0	0.976	0.98
Non-Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	1.0	1.0	1.0

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.751	0.587	0.83	0.621

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	POU {3.1.10} (TFClass)
TF subfamily	HNF1-like {3.1.10.7} (TFClass)
TFClass ID	TFClass: 3.1.10.7.1
HGNC	HGNC:11621
MGI	MGI:98504
EntrezGene (human)	GeneID:6927 (SSTAR profile)
EntrezGene (mouse)	GeneID:21405 (SSTAR profile)
UniProt ID (human)	HNF1A_HUMAN
UniProt ID (mouse)	HNF1A_MOUSE
UniProt AC (human)	P20823 (TFClass)
UniProt AC (mouse)	P22361 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	HNF1A.H12CORE.0.PS.A.pcm
PWM	HNF1A.H12CORE.0.PS.A.pwm
PFM	HNF1A.H12CORE.0.PS.A.pfm
Alignment	HNF1A.H12CORE.0.PS.A.words.tsv
Threshold to P-value map	HNF1A.H12CORE.0.PS.A.thr
Motif in other formats
JASPAR format	HNF1A.H12CORE.0.PS.A_jaspar_format.txt
MEME format	HNF1A.H12CORE.0.PS.A_meme_format.meme
Transfac format	HNF1A.H12CORE.0.PS.A_transfac_format.txt
Homer format	HNF1A.H12CORE.0.PS.A_homer_format_0.001.txt HNF1A.H12CORE.0.PS.A_homer_format_0.0005.txt HNF1A.H12CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	313.0	52.0	429.0	205.0
02	109.0	36.0	779.0	75.0
03	27.0	84.0	61.0	827.0
04	109.0	80.0	42.0	768.0
05	959.0	3.0	27.0	10.0
06	913.0	55.0	3.0	28.0
07	122.0	11.0	1.0	865.0
08	347.0	0.0	652.0	0.0
09	673.0	16.0	51.0	259.0
10	66.0	4.0	91.0	838.0
11	12.0	47.0	9.0	931.0
12	770.0	32.0	98.0	99.0
13	802.0	78.0	71.0	48.0
14	77.0	756.0	33.0	133.0
15	220.0	399.0	56.0	324.0

PFM

	A	C	G	T
01	0.313	0.052	0.429	0.205
02	0.109	0.036	0.78	0.075
03	0.027	0.084	0.061	0.828
04	0.109	0.08	0.042	0.769
05	0.96	0.003	0.027	0.01
06	0.914	0.055	0.003	0.028
07	0.122	0.011	0.001	0.866
08	0.347	0.0	0.653	0.0
09	0.674	0.016	0.051	0.259
10	0.066	0.004	0.091	0.839
11	0.012	0.047	0.009	0.932
12	0.771	0.032	0.098	0.099
13	0.803	0.078	0.071	0.048
14	0.077	0.757	0.033	0.133
15	0.22	0.399	0.056	0.324

PWM

	A	C	G	T
01	0.224	-1.543	0.538	-0.196
02	-0.82	-1.897	1.133	-1.187
03	-2.17	-1.076	-1.389	1.193
04	-0.82	-1.124	-1.749	1.119
05	1.34	-3.974	-2.17	-3.065
06	1.291	-1.489	-3.974	-2.135
07	-0.709	-2.984	-4.524	1.237
08	0.327	-4.981	0.955	-4.981
09	0.987	-2.652	-1.562	0.036
10	-1.312	-3.782	-0.998	1.206
11	-2.908	-1.641	-3.155	1.311
12	1.121	-2.009	-0.925	-0.915
13	1.162	-1.149	-1.241	-1.621
14	-1.161	1.103	-1.98	-0.624
15	-0.126	0.466	-1.472	0.259

Standard thresholds

P-value	Threshold
0.001	3.09356
0.0005	4.20741
0.0001	6.53881