HIF1A.H12INVITRO.1.P.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HIF1A.H12INVITRO.1.P.D
Gene (human)	HIF1A (GeneCards)
Gene synonyms (human)	BHLHE78, MOP1, PASD8
Gene (mouse)	Hif1a
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	19
Consensus	vdACGTGMbnnnnnnSvbv
GC content	58.33%
Information content (bits; total / per base)	10.903 / 0.574
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	24 (137)	0.843	0.932	0.785	0.891	0.818	0.931	3.324	4.426	177.796	467.292
Mouse	4 (25)	0.826	0.876	0.736	0.807	0.819	0.869	3.014	3.76	167.509	275.538

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	12.878	9.734	0.287	0.17

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	PAS {1.2.5} (TFClass)
TF subfamily	PAS-AHR {1.2.5.1} (TFClass)
TFClass ID	TFClass: 1.2.5.1.5
HGNC	HGNC:4910
MGI	MGI:106918
EntrezGene (human)	GeneID:3091 (SSTAR profile)
EntrezGene (mouse)	GeneID:15251 (SSTAR profile)
UniProt ID (human)	HIF1A_HUMAN
UniProt ID (mouse)	HIF1A_MOUSE
UniProt AC (human)	Q16665 (TFClass)
UniProt AC (mouse)	Q61221 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	24 human, 4 mouse
HT-SELEX	0
Methyl-HT-SELEX	0

PCM	HIF1A.H12INVITRO.1.P.D.pcm
PWM	HIF1A.H12INVITRO.1.P.D.pwm
PFM	HIF1A.H12INVITRO.1.P.D.pfm
Alignment	HIF1A.H12INVITRO.1.P.D.words.tsv
Threshold to P-value map	HIF1A.H12INVITRO.1.P.D.thr
Motif in other formats
JASPAR format	HIF1A.H12INVITRO.1.P.D_jaspar_format.txt
MEME format	HIF1A.H12INVITRO.1.P.D_meme_format.meme
Transfac format	HIF1A.H12INVITRO.1.P.D_transfac_format.txt
Homer format	HIF1A.H12INVITRO.1.P.D_homer_format_0.001.txt HIF1A.H12INVITRO.1.P.D_homer_format_0.0005.txt HIF1A.H12INVITRO.1.P.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	158.0	278.0	490.0	74.0
02	144.0	104.0	237.0	515.0
03	856.0	13.0	129.0	2.0
04	4.0	939.0	21.0	36.0
05	32.0	30.0	934.0	4.0
06	2.0	1.0	2.0	995.0
07	0.0	0.0	998.0	2.0
08	272.0	589.0	43.0	96.0
09	178.0	404.0	203.0	215.0
10	175.0	243.0	228.0	354.0
11	248.0	185.0	374.0	193.0
12	228.0	257.0	255.0	260.0
13	218.0	287.0	280.0	215.0
14	240.0	223.0	320.0	217.0
15	177.0	194.0	369.0	260.0
16	103.0	638.0	182.0	77.0
17	539.0	162.0	190.0	109.0
18	136.0	384.0	253.0	227.0
19	244.0	156.0	488.0	112.0

PFM

	A	C	G	T
01	0.158	0.278	0.49	0.074
02	0.144	0.104	0.237	0.515
03	0.856	0.013	0.129	0.002
04	0.004	0.939	0.021	0.036
05	0.032	0.03	0.934	0.004
06	0.002	0.001	0.002	0.995
07	0.0	0.0	0.998	0.002
08	0.272	0.589	0.043	0.096
09	0.178	0.404	0.203	0.215
10	0.175	0.243	0.228	0.354
11	0.248	0.185	0.374	0.193
12	0.228	0.257	0.255	0.26
13	0.218	0.287	0.28	0.215
14	0.24	0.223	0.32	0.217
15	0.177	0.194	0.369	0.26
16	0.103	0.638	0.182	0.077
17	0.539	0.162	0.19	0.109
18	0.136	0.384	0.253	0.227
19	0.244	0.156	0.488	0.112

PWM

	A	C	G	T
01	-0.455	0.105	0.67	-1.201
02	-0.547	-0.867	-0.053	0.719
03	1.226	-2.839	-0.655	-4.213
04	-3.783	1.318	-2.405	-1.898
05	-2.01	-2.071	1.313	-3.783
06	-4.213	-4.525	-4.213	1.376
07	-4.982	-4.982	1.379	-4.213
08	0.084	0.853	-1.728	-0.946
09	-0.337	0.477	-0.207	-0.15
10	-0.354	-0.028	-0.091	0.346
11	-0.008	-0.299	0.401	-0.257
12	-0.091	0.027	0.02	0.039
13	-0.136	0.137	0.113	-0.15
14	-0.041	-0.113	0.245	-0.141
15	-0.342	-0.252	0.387	0.039
16	-0.877	0.933	-0.315	-1.162
17	0.765	-0.43	-0.272	-0.821
18	-0.603	0.427	0.012	-0.096
19	-0.024	-0.467	0.666	-0.795

Standard thresholds

P-value	Threshold
0.001	4.55656
0.0005	5.54311
0.0001	7.40831