HESX1.H12INVITRO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HESX1.H12INVITRO.1.S.B
Gene (human)	HESX1 (GeneCards)
Gene synonyms (human)	HANF
Gene (mouse)	Hesx1
Gene synonyms (mouse)	Hes-1, Rpx
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	17
Consensus	hWWWWddYTAATTAvbn
GC content	20.03%
Information content (bits; total / per base)	15.576 / 0.916
Data sources	HT-SELEX
Aligned words	1997

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.756	0.744	0.615	0.629	0.548	0.572
Overall, 4 experiments	best	0.851	0.857	0.634	0.677	0.556	0.596
Methyl HT-SELEX, 1 experiments	median	0.733	0.711	0.614	0.617	0.556	0.569
Methyl HT-SELEX, 1 experiments	best	0.733	0.711	0.614	0.617	0.556	0.569
Non-Methyl HT-SELEX, 3 experiments	median	0.779	0.774	0.615	0.64	0.543	0.576
Non-Methyl HT-SELEX, 3 experiments	best	0.851	0.857	0.634	0.677	0.552	0.596

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.893	0.552	0.81	0.471
batch 2	0.543	0.091	0.495	0.358

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	HESX {3.1.3.10} (TFClass)
TFClass ID	TFClass: 3.1.3.10.1
HGNC	HGNC:4877
MGI	MGI:96071
EntrezGene (human)	GeneID:8820 (SSTAR profile)
EntrezGene (mouse)	GeneID:15209 (SSTAR profile)
UniProt ID (human)	HESX1_HUMAN
UniProt ID (mouse)	HESX1_MOUSE
UniProt AC (human)	Q9UBX0 (TFClass)
UniProt AC (mouse)	Q61658 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	HESX1.H12INVITRO.1.S.B.pcm
PWM	HESX1.H12INVITRO.1.S.B.pwm
PFM	HESX1.H12INVITRO.1.S.B.pfm
Alignment	HESX1.H12INVITRO.1.S.B.words.tsv
Threshold to P-value map	HESX1.H12INVITRO.1.S.B.thr
Motif in other formats
JASPAR format	HESX1.H12INVITRO.1.S.B_jaspar_format.txt
MEME format	HESX1.H12INVITRO.1.S.B_meme_format.meme
Transfac format	HESX1.H12INVITRO.1.S.B_transfac_format.txt
Homer format	HESX1.H12INVITRO.1.S.B_homer_format_0.001.txt HESX1.H12INVITRO.1.S.B_homer_format_0.0005.txt HESX1.H12INVITRO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	668.75	232.75	221.75	873.75
02	934.5	77.5	161.5	823.5
03	1297.0	89.0	48.0	563.0
04	765.0	32.0	53.0	1147.0
05	479.0	92.0	163.0	1263.0
06	1010.0	82.0	290.0	615.0
07	974.0	93.0	537.0	393.0
08	85.0	776.0	159.0	977.0
09	0.0	597.0	0.0	1400.0
10	1997.0	0.0	0.0	0.0
11	1997.0	0.0	0.0	0.0
12	0.0	0.0	0.0	1997.0
13	0.0	0.0	0.0	1997.0
14	1989.0	0.0	8.0	0.0
15	934.0	201.0	709.0	153.0
16	313.25	869.25	353.25	461.25
17	566.75	501.75	453.75	474.75

PFM

	A	C	G	T
01	0.335	0.117	0.111	0.438
02	0.468	0.039	0.081	0.412
03	0.649	0.045	0.024	0.282
04	0.383	0.016	0.027	0.574
05	0.24	0.046	0.082	0.632
06	0.506	0.041	0.145	0.308
07	0.488	0.047	0.269	0.197
08	0.043	0.389	0.08	0.489
09	0.0	0.299	0.0	0.701
10	1.0	0.0	0.0	0.0
11	1.0	0.0	0.0	0.0
12	0.0	0.0	0.0	1.0
13	0.0	0.0	0.0	1.0
14	0.996	0.0	0.004	0.0
15	0.468	0.101	0.355	0.077
16	0.157	0.435	0.177	0.231
17	0.284	0.251	0.227	0.238

PWM

	A	C	G	T
01	0.291	-0.759	-0.807	0.558
02	0.625	-1.842	-1.121	0.499
03	0.952	-1.707	-2.307	0.12
04	0.425	-2.693	-2.211	0.83
05	-0.041	-1.675	-1.112	0.926
06	0.703	-1.787	-0.54	0.208
07	0.666	-1.664	0.073	-0.238
08	-1.752	0.44	-1.136	0.67
09	-5.575	0.178	-5.575	1.029
10	1.383	-5.575	-5.575	-5.575
11	1.383	-5.575	-5.575	-5.575
12	-5.575	-5.575	-5.575	1.383
13	-5.575	-5.575	-5.575	1.383
14	1.379	-5.575	-3.924	-5.575
15	0.625	-0.904	0.35	-1.174
16	-0.464	0.553	-0.344	-0.079
17	0.126	0.005	-0.095	-0.05

Standard thresholds

P-value	Threshold
0.001	1.06786
0.0005	2.61671
0.0001	6.11461