HESX1.H12CORE.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HESX1.H12CORE.1.S.B
Gene (human)	HESX1 (GeneCards)
Gene synonyms (human)	HANF
Gene (mouse)	Hesx1
Gene synonyms (mouse)	Hes-1, Rpx
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	16
Consensus	dWWWdWYTAATTAnbn
GC content	19.49%
Information content (bits; total / per base)	15.753 / 0.985
Data sources	HT-SELEX
Aligned words	652

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.751	0.74	0.613	0.626	0.546	0.57
Overall, 4 experiments	best	0.849	0.853	0.634	0.676	0.554	0.595
Methyl HT-SELEX, 1 experiments	median	0.728	0.705	0.612	0.614	0.554	0.567
Methyl HT-SELEX, 1 experiments	best	0.728	0.705	0.612	0.614	0.554	0.567
Non-Methyl HT-SELEX, 3 experiments	median	0.775	0.769	0.614	0.638	0.541	0.574
Non-Methyl HT-SELEX, 3 experiments	best	0.849	0.853	0.634	0.676	0.552	0.595

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.888	0.517	0.798	0.458
batch 2	0.579	0.145	0.478	0.385

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	HESX {3.1.3.10} (TFClass)
TFClass ID	TFClass: 3.1.3.10.1
HGNC	HGNC:4877
MGI	MGI:96071
EntrezGene (human)	GeneID:8820 (SSTAR profile)
EntrezGene (mouse)	GeneID:15209 (SSTAR profile)
UniProt ID (human)	HESX1_HUMAN
UniProt ID (mouse)	HESX1_MOUSE
UniProt AC (human)	Q9UBX0 (TFClass)
UniProt AC (mouse)	Q61658 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	HESX1.H12CORE.1.S.B.pcm
PWM	HESX1.H12CORE.1.S.B.pwm
PFM	HESX1.H12CORE.1.S.B.pfm
Alignment	HESX1.H12CORE.1.S.B.words.tsv
Threshold to P-value map	HESX1.H12CORE.1.S.B.thr
Motif in other formats
JASPAR format	HESX1.H12CORE.1.S.B_jaspar_format.txt
MEME format	HESX1.H12CORE.1.S.B_meme_format.meme
Transfac format	HESX1.H12CORE.1.S.B_transfac_format.txt
Homer format	HESX1.H12CORE.1.S.B_homer_format_0.001.txt HESX1.H12CORE.1.S.B_homer_format_0.0005.txt HESX1.H12CORE.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	307.75	36.75	70.75	236.75
02	408.0	62.0	13.0	169.0
03	219.0	6.0	16.0	411.0
04	178.0	29.0	45.0	400.0
05	340.0	27.0	108.0	177.0
06	332.0	7.0	138.0	175.0
07	17.0	209.0	59.0	367.0
08	0.0	127.0	0.0	525.0
09	652.0	0.0	0.0	0.0
10	652.0	0.0	0.0	0.0
11	0.0	0.0	0.0	652.0
12	0.0	0.0	0.0	652.0
13	652.0	0.0	0.0	0.0
14	295.0	62.0	233.0	62.0
15	70.75	355.75	93.75	131.75
16	157.25	183.25	152.25	159.25

PFM

	A	C	G	T
01	0.472	0.056	0.109	0.363
02	0.626	0.095	0.02	0.259
03	0.336	0.009	0.025	0.63
04	0.273	0.044	0.069	0.613
05	0.521	0.041	0.166	0.271
06	0.509	0.011	0.212	0.268
07	0.026	0.321	0.09	0.563
08	0.0	0.195	0.0	0.805
09	1.0	0.0	0.0	0.0
10	1.0	0.0	0.0	0.0
11	0.0	0.0	0.0	1.0
12	0.0	0.0	0.0	1.0
13	1.0	0.0	0.0	0.0
14	0.452	0.095	0.357	0.095
15	0.109	0.546	0.144	0.202
16	0.241	0.281	0.234	0.244

PWM

	A	C	G	T
01	0.631	-1.456	-0.822	0.37
02	0.912	-0.951	-2.421	0.036
03	0.293	-3.073	-2.235	0.919
04	0.087	-1.682	-1.262	0.892
05	0.73	-1.75	-0.407	0.082
06	0.706	-2.95	-0.165	0.07
07	-2.179	0.246	-0.999	0.806
08	-4.621	-0.247	-4.621	1.163
09	1.379	-4.621	-4.621	-4.621
10	1.379	-4.621	-4.621	-4.621
11	-4.621	-4.621	-4.621	1.379
12	-4.621	-4.621	-4.621	1.379
13	1.379	-4.621	-4.621	-4.621
14	0.589	-0.951	0.354	-0.951
15	-0.822	0.775	-0.546	-0.211
16	-0.036	0.116	-0.068	-0.023

Standard thresholds

P-value	Threshold
0.001	1.72781
0.0005	3.15661
0.0001	6.18371