HES5.H12INVITRO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HES5.H12INVITRO.0.SM.B
Gene (human)	HES5 (GeneCards)
Gene synonyms (human)	BHLHB38
Gene (mouse)	Hes5
Gene synonyms (mouse)	Hes-5
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	ndhGGCACGTGYYn
GC content	64.59%
Information content (bits; total / per base)	15.775 / 1.127
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	6631

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 5 experiments	median	0.809	0.818	0.659	0.676	0.586	0.605
Overall, 5 experiments	best	1.0	0.999	0.999	0.999	0.997	0.997
Methyl HT-SELEX, 1 experiments	median	0.991	0.989	0.927	0.917	0.827	0.818
Methyl HT-SELEX, 1 experiments	best	0.991	0.989	0.927	0.917	0.827	0.818
Non-Methyl HT-SELEX, 4 experiments	median	0.759	0.774	0.63	0.648	0.571	0.588
Non-Methyl HT-SELEX, 4 experiments	best	1.0	0.999	0.999	0.999	0.997	0.997

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.579	0.207	0.364	0.011

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Hairy-related {1.2.4} (TFClass)
TF subfamily	HAIRY {1.2.4.1} (TFClass)
TFClass ID	TFClass: 1.2.4.1.5
HGNC	HGNC:19764
MGI	MGI:104876
EntrezGene (human)	GeneID:388585 (SSTAR profile)
EntrezGene (mouse)	GeneID:15208 (SSTAR profile)
UniProt ID (human)	HES5_HUMAN
UniProt ID (mouse)	HES5_MOUSE
UniProt AC (human)	Q5TA89 (TFClass)
UniProt AC (mouse)	P70120 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	1

PCM	HES5.H12INVITRO.0.SM.B.pcm
PWM	HES5.H12INVITRO.0.SM.B.pwm
PFM	HES5.H12INVITRO.0.SM.B.pfm
Alignment	HES5.H12INVITRO.0.SM.B.words.tsv
Threshold to P-value map	HES5.H12INVITRO.0.SM.B.thr
Motif in other formats
JASPAR format	HES5.H12INVITRO.0.SM.B_jaspar_format.txt
MEME format	HES5.H12INVITRO.0.SM.B_meme_format.meme
Transfac format	HES5.H12INVITRO.0.SM.B_transfac_format.txt
Homer format	HES5.H12INVITRO.0.SM.B_homer_format_0.001.txt HES5.H12INVITRO.0.SM.B_homer_format_0.0005.txt HES5.H12INVITRO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1048.5	1945.5	1537.5	2099.5
02	2379.0	919.0	1394.0	1939.0
03	1372.0	2187.0	847.0	2225.0
04	362.0	40.0	6182.0	47.0
05	488.0	129.0	6010.0	4.0
06	3.0	6627.0	1.0	0.0
07	6631.0	0.0	0.0	0.0
08	1.0	6617.0	2.0	11.0
09	122.0	4.0	6502.0	3.0
10	7.0	327.0	4.0	6293.0
11	27.0	18.0	6459.0	127.0
12	66.0	2354.0	809.0	3402.0
13	362.0	4465.0	865.0	939.0
14	1716.75	1546.75	2167.75	1199.75

PFM

	A	C	G	T
01	0.158	0.293	0.232	0.317
02	0.359	0.139	0.21	0.292
03	0.207	0.33	0.128	0.336
04	0.055	0.006	0.932	0.007
05	0.074	0.019	0.906	0.001
06	0.0	0.999	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.998	0.0	0.002
09	0.018	0.001	0.981	0.0
10	0.001	0.049	0.001	0.949
11	0.004	0.003	0.974	0.019
12	0.01	0.355	0.122	0.513
13	0.055	0.673	0.13	0.142
14	0.259	0.233	0.327	0.181

PWM

	A	C	G	T
01	-0.457	0.16	-0.075	0.236
02	0.361	-0.589	-0.173	0.157
03	-0.189	0.277	-0.67	0.294
04	-1.517	-3.672	1.315	-3.519
05	-1.22	-2.538	1.287	-5.59
06	-5.766	1.385	-6.251	-6.626
07	1.385	-6.626	-6.626	-6.626
08	-6.251	1.383	-5.979	-4.834
09	-2.593	-5.59	1.366	-5.766
10	-5.195	-1.618	-5.59	1.333
11	-4.04	-4.409	1.359	-2.553
12	-3.192	0.35	-0.716	0.718
13	-1.517	0.99	-0.649	-0.567
14	0.035	-0.069	0.268	-0.323

Standard thresholds

P-value	Threshold
0.001	0.76421
0.0005	2.43856
0.0001	5.793365