HEN2.H12INVITRO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HEN2.H12INVITRO.0.SM.B
Gene (human)	NHLH2 (GeneCards)
Gene synonyms (human)	BHLHA34, HEN2, KIAA0490
Gene (mouse)	Nhlh2
Gene synonyms (mouse)	Hen2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	16
Consensus	ndKGdCGCAGCTGSKn
GC content	68.52%
Information content (bits; total / per base)	18.531 / 1.158
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9992

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.997	0.996	0.95	0.95	0.853	0.867
Overall, 2 experiments	best	1.0	1.0	0.999	0.999	0.974	0.975
Methyl HT-SELEX, 1 experiments	median	0.995	0.993	0.901	0.901	0.732	0.759
Methyl HT-SELEX, 1 experiments	best	0.995	0.993	0.901	0.901	0.732	0.759
Non-Methyl HT-SELEX, 1 experiments	median	1.0	1.0	0.999	0.999	0.974	0.975
Non-Methyl HT-SELEX, 1 experiments	best	1.0	1.0	0.999	0.999	0.974	0.975

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	TAL-HEN {1.2.3.1} (TFClass)
TFClass ID	TFClass: 1.2.3.1.5
HGNC	HGNC:7818
MGI	MGI:97324
EntrezGene (human)	GeneID:4808 (SSTAR profile)
EntrezGene (mouse)	GeneID:18072 (SSTAR profile)
UniProt ID (human)	HEN2_HUMAN
UniProt ID (mouse)	HEN2_MOUSE
UniProt AC (human)	Q02577 (TFClass)
UniProt AC (mouse)	Q64221 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	HEN2.H12INVITRO.0.SM.B.pcm
PWM	HEN2.H12INVITRO.0.SM.B.pwm
PFM	HEN2.H12INVITRO.0.SM.B.pfm
Alignment	HEN2.H12INVITRO.0.SM.B.words.tsv
Threshold to P-value map	HEN2.H12INVITRO.0.SM.B.thr
Motif in other formats
JASPAR format	HEN2.H12INVITRO.0.SM.B_jaspar_format.txt
MEME format	HEN2.H12INVITRO.0.SM.B_meme_format.meme
Transfac format	HEN2.H12INVITRO.0.SM.B_transfac_format.txt
Homer format	HEN2.H12INVITRO.0.SM.B_homer_format_0.001.txt HEN2.H12INVITRO.0.SM.B_homer_format_0.0005.txt HEN2.H12INVITRO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2548.5	1761.5	3412.5	2269.5
02	2070.25	702.25	5671.25	1548.25
03	1026.0	342.0	6858.0	1766.0
04	622.0	157.0	8214.0	999.0
05	5135.0	916.0	2626.0	1315.0
06	1327.0	8517.0	91.0	57.0
07	182.0	137.0	9372.0	301.0
08	0.0	9988.0	1.0	3.0
09	9991.0	0.0	0.0	1.0
10	0.0	43.0	9912.0	37.0
11	142.0	9653.0	197.0	0.0
12	0.0	1.0	0.0	9991.0
13	1.0	0.0	9987.0	4.0
14	1067.0	6893.0	1297.0	735.0
15	184.75	401.75	6864.75	2540.75
16	1630.25	2681.25	2844.25	2836.25

PFM

	A	C	G	T
01	0.255	0.176	0.342	0.227
02	0.207	0.07	0.568	0.155
03	0.103	0.034	0.686	0.177
04	0.062	0.016	0.822	0.1
05	0.514	0.092	0.263	0.132
06	0.133	0.852	0.009	0.006
07	0.018	0.014	0.938	0.03
08	0.0	1.0	0.0	0.0
09	1.0	0.0	0.0	0.0
10	0.0	0.004	0.992	0.004
11	0.014	0.966	0.02	0.0
12	0.0	0.0	0.0	1.0
13	0.0	0.0	0.999	0.0
14	0.107	0.69	0.13	0.074
15	0.018	0.04	0.687	0.254
16	0.163	0.268	0.285	0.284

PWM

	A	C	G	T
01	0.02	-0.349	0.312	-0.096
02	-0.188	-1.267	0.819	-0.478
03	-0.889	-1.983	1.009	-0.346
04	-1.388	-2.753	1.19	-0.915
05	0.72	-1.002	0.05	-0.641
06	-0.632	1.226	-3.288	-3.742
07	-2.608	-2.888	1.322	-2.109
08	-6.99	1.385	-6.63	-6.156
09	1.386	-6.99	-6.99	-6.63
10	-6.99	-4.011	1.378	-4.153
11	-2.852	1.351	-2.529	-6.99
12	-6.99	-6.63	-6.99	1.386
13	-6.63	-6.99	1.385	-5.983
14	-0.849	1.014	-0.655	-1.221
15	-2.593	-1.823	1.01	0.017
16	-0.426	0.071	0.13	0.127

Standard thresholds

P-value	Threshold
0.001	-1.40499
0.0005	0.45956
0.0001	4.33416