HAND2.H12INVIVO.2.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HAND2.H12INVIVO.2.S.C
Gene (human)	HAND2 (GeneCards)
Gene synonyms (human)	BHLHA26, DHAND
Gene (mouse)	Hand2
Gene synonyms (mouse)	Dhand, Hed, Thing2
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	C

Motif length	16
Consensus	bnhvCACCTGCRhhhn
GC content	58.89%
Information content (bits; total / per base)	15.77 / 0.986
Data sources	HT-SELEX
Aligned words	594

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (26)	0.495	0.505	0.329	0.34	0.518	0.547	1.039	1.151	0.297	2.237
Mouse	1 (7)	0.51	0.515	0.343	0.352	0.533	0.581	1.073	1.233	1.699	4.036

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.792	0.773	0.647	0.654	0.578	0.592
Non-Methyl HT-SELEX, 1 experiments	best	0.792	0.773	0.647	0.654	0.578	0.592

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	TWIST {1.2.3.2} (TFClass)
TFClass ID	TFClass: 1.2.3.2.4
HGNC	HGNC:4808
MGI	MGI:103580
EntrezGene (human)	GeneID:9464 (SSTAR profile)
EntrezGene (mouse)	GeneID:15111 (SSTAR profile)
UniProt ID (human)	HAND2_HUMAN
UniProt ID (mouse)	HAND2_MOUSE
UniProt AC (human)	P61296 (TFClass)
UniProt AC (mouse)	Q61039 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	HAND2.H12INVIVO.2.S.C.pcm
PWM	HAND2.H12INVIVO.2.S.C.pwm
PFM	HAND2.H12INVIVO.2.S.C.pfm
Alignment	HAND2.H12INVIVO.2.S.C.words.tsv
Threshold to P-value map	HAND2.H12INVIVO.2.S.C.thr
Motif in other formats
JASPAR format	HAND2.H12INVIVO.2.S.C_jaspar_format.txt
MEME format	HAND2.H12INVIVO.2.S.C_meme_format.meme
Transfac format	HAND2.H12INVIVO.2.S.C_transfac_format.txt
Homer format	HAND2.H12INVIVO.2.S.C_homer_format_0.001.txt HAND2.H12INVIVO.2.S.C_homer_format_0.0005.txt HAND2.H12INVIVO.2.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	89.75	228.75	106.75	168.75
02	126.75	103.75	220.75	142.75
03	244.0	174.0	22.0	154.0
04	274.0	44.0	274.0	2.0
05	0.0	594.0	0.0	0.0
06	594.0	0.0	0.0	0.0
07	0.0	594.0	0.0	0.0
08	0.0	594.0	0.0	0.0
09	0.0	0.0	0.0	594.0
10	0.0	0.0	594.0	0.0
11	0.0	559.0	16.0	19.0
12	388.0	33.0	128.0	45.0
13	122.0	295.0	68.0	109.0
14	118.0	243.0	104.0	129.0
15	104.25	197.25	74.25	218.25
16	127.5	176.5	152.5	137.5

PFM

	A	C	G	T
01	0.151	0.385	0.18	0.284
02	0.213	0.175	0.372	0.24
03	0.411	0.293	0.037	0.259
04	0.461	0.074	0.461	0.003
05	0.0	1.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	1.0	0.0	0.0
08	0.0	1.0	0.0	0.0
09	0.0	0.0	0.0	1.0
10	0.0	0.0	1.0	0.0
11	0.0	0.941	0.027	0.032
12	0.653	0.056	0.215	0.076
13	0.205	0.497	0.114	0.184
14	0.199	0.409	0.175	0.217
15	0.176	0.332	0.125	0.367
16	0.215	0.297	0.257	0.231

PWM

	A	C	G	T
01	-0.497	0.428	-0.326	0.127
02	-0.157	-0.354	0.393	-0.039
03	0.492	0.157	-1.85	0.036
04	0.608	-1.191	0.608	-3.731
05	-4.543	1.378	-4.543	-4.543
06	1.378	-4.543	-4.543	-4.543
07	-4.543	1.378	-4.543	-4.543
08	-4.543	1.378	-4.543	-4.543
09	-4.543	-4.543	-4.543	1.378
10	-4.543	-4.543	1.378	-4.543
11	-4.543	1.318	-2.144	-1.986
12	0.954	-1.468	-0.147	-1.17
13	-0.194	0.681	-0.769	-0.305
14	-0.227	0.488	-0.352	-0.139
15	-0.349	0.281	-0.683	0.382
16	-0.151	0.171	0.026	-0.076

Standard thresholds

P-value	Threshold
0.001	1.40406
0.0005	3.04846
0.0001	5.86041