HAND2.H12INVIVO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	HAND2.H12INVIVO.1.P.B
Gene (human)	HAND2 (GeneCards)
Gene synonyms (human)	BHLHA26, DHAND
Gene (mouse)	Hand2
Gene synonyms (mouse)	Dhand, Hed, Thing2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	vdKSYCTGGnhdbb
GC content	61.3%
Information content (bits; total / per base)	10.162 / 0.726
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (26)	0.754	0.786	0.581	0.618	0.698	0.783	1.847	2.293	51.891	85.125
Mouse	1 (7)	0.703	0.73	0.542	0.568	0.694	0.705	1.834	1.862	23.62	40.174

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.43	0.462	0.46	0.474	0.484	0.485
Non-Methyl HT-SELEX, 1 experiments	best	0.43	0.462	0.46	0.474	0.484	0.485

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	TWIST {1.2.3.2} (TFClass)
TFClass ID	TFClass: 1.2.3.2.4
HGNC	HGNC:4808
MGI	MGI:103580
EntrezGene (human)	GeneID:9464 (SSTAR profile)
EntrezGene (mouse)	GeneID:15111 (SSTAR profile)
UniProt ID (human)	HAND2_HUMAN
UniProt ID (mouse)	HAND2_MOUSE
UniProt AC (human)	P61296 (TFClass)
UniProt AC (mouse)	Q61039 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 1 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	HAND2.H12INVIVO.1.P.B.pcm
PWM	HAND2.H12INVIVO.1.P.B.pwm
PFM	HAND2.H12INVIVO.1.P.B.pfm
Alignment	HAND2.H12INVIVO.1.P.B.words.tsv
Threshold to P-value map	HAND2.H12INVIVO.1.P.B.thr
Motif in other formats
JASPAR format	HAND2.H12INVIVO.1.P.B_jaspar_format.txt
MEME format	HAND2.H12INVIVO.1.P.B_meme_format.meme
Transfac format	HAND2.H12INVIVO.1.P.B_transfac_format.txt
Homer format	HAND2.H12INVIVO.1.P.B_homer_format_0.001.txt HAND2.H12INVIVO.1.P.B_homer_format_0.0005.txt HAND2.H12INVIVO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	187.0	286.0	392.0	135.0
02	320.0	39.0	455.0	186.0
03	112.0	117.0	631.0	140.0
04	43.0	286.0	625.0	46.0
05	28.0	480.0	45.0	447.0
06	12.0	970.0	15.0	3.0
07	2.0	1.0	0.0	997.0
08	1.0	2.0	995.0	2.0
09	3.0	107.0	840.0	50.0
10	268.0	361.0	169.0	202.0
11	255.0	277.0	97.0	371.0
12	216.0	56.0	166.0	562.0
13	58.0	275.0	383.0	284.0
14	56.0	365.0	147.0	432.0

PFM

	A	C	G	T
01	0.187	0.286	0.392	0.135
02	0.32	0.039	0.455	0.186
03	0.112	0.117	0.631	0.14
04	0.043	0.286	0.625	0.046
05	0.028	0.48	0.045	0.447
06	0.012	0.97	0.015	0.003
07	0.002	0.001	0.0	0.997
08	0.001	0.002	0.995	0.002
09	0.003	0.107	0.84	0.05
10	0.268	0.361	0.169	0.202
11	0.255	0.277	0.097	0.371
12	0.216	0.056	0.166	0.562
13	0.058	0.275	0.383	0.284
14	0.056	0.365	0.147	0.432

PWM

	A	C	G	T
01	-0.288	0.134	0.447	-0.61
02	0.245	-1.821	0.596	-0.293
03	-0.795	-0.752	0.922	-0.574
04	-1.728	0.134	0.912	-1.663
05	-2.136	0.649	-1.684	0.578
06	-2.909	1.351	-2.711	-3.975
07	-4.213	-4.525	-4.982	1.378
08	-4.525	-4.213	1.376	-4.213
09	-3.975	-0.84	1.207	-1.582
10	0.069	0.365	-0.388	-0.212
11	0.02	0.102	-0.936	0.393
12	-0.145	-1.473	-0.406	0.806
13	-1.439	0.095	0.424	0.127
14	-1.473	0.376	-0.526	0.544

Standard thresholds

P-value	Threshold
0.001	4.81871
0.0005	5.72781
0.0001	7.42411